Furamag, capsules 50mg, 30pcs

Composition

1 capsule contains:

Active ingredient:

furazidine potassium 50 mg,

excipients:

potassium carbonate;

magnesium hydroxycarbonate;

talc

Pharmacological action

Pharmacodynamics

Furamag is a broad-spectrum antimicrobial agent belonging to the nitrofuran group.

Resistance to Furamag develops slowly and does not reach a high degree.

Active against gram-positive and gram-negative microbes, pathogenic strains of Staphylococcus spp. and other microorganisms resistant to antibiotics.

It is effective against gram-positive cocci (streptococci, staphylococci), gram-negative bacilli (Escherichia coli, Salmonella, Shigella, Proteus, klebsiella, Enterobacteria), protozoa (Giardia). Furamag® is more active against Staphylococcus spp., E. coli, Aerobacter aerogenes, Bact. citrovorum, Proteus mirabilis, and Proteus morganii compared to other nitrofurans. Furamag® is more active against Enterococcus faecalis, Staphylococcus spp. compared to other groups of antimicrobials.

Against most of the bacteria, the bacteriostatic concentration ranges from 1: 100,000 to 1: 200,000; the bactericidal concentration is approximately 2 times higher. Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, as well as other biochemical processes in microorganisms are inhibited, resulting in the destruction of their shell or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms secrete fewer toxins, and therefore an improvement in the general condition of the patient is possible even before the pronounced suppression of microflora growth. Nitrofurans, unlike many other antimicrobial agents, not only do not depress the body’s immune system, but on the contrary activate it (they increase the complement titer and the ability of white blood cells to phagocytize microorganisms). Nitrofurans in therapeutic doses stimulate leukopoiesis.

Pharmacokinetics

Absorption occurs in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and middle segments by 2 and 4 times, respectively (it should be taken into account in the simultaneous treatment of urogenital infections and gastrointestinal diseases, including chronic enteritis). Nitrofurans are poorly absorbed in the colon.

Furamag, being a mixture of potassium furazidine and magnesium hydroxycarbonate in a ratio of 1: 1, when administered orally has a higher bioavailability than furazidine (after taking the Furamag capsule in the acidic environment of the stomach, furazidine potassium does not turn into poorly soluble furazidine). In the body, the drug is distributed evenly. Clinically important is the high content of Active ingredient in the lymph (delays the spread of infection along the lymphatic pathways). In the bile, its concentration is several times higher than in the blood serum, and in the cerebrospinal fluid-several times lower than in the serum. In saliva, the content of furazidine is 30% of its concentration in the blood serum. The concentration of furazidine in the blood and tissues is relatively small, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. Cmax in the blood remains from 3 to 7 or 8 hours, in the urine furazidine is detected 3-4 hours after application.

Unlike nitrofurantoin (furadonin), after taking Furamag, the pH of urine does not change. 4 hours after taking the drug, the concentration of furazidine in the urine significantly exceeds the concentration that is formed after taking the same dose of the drug Furagin. Excretion through the kidneys occurs during glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of the drug in the urine, the process of filtration and secretion prevails, at high concentrations, secretion decreases and reabsorption increases. Furazidine, being a weak acid, does not dissociate in acidic urine, undergoes intensive reabsorption, which can increase the development of systemic side effects. When the urine is alkalinized, the excretion of furazidine increases.

Slightly biotransformed (less than 10%). With a decrease in the excretory function of the kidneys, the intensity of metabolism increases.

Indications

Infections caused by furazidine-sensitive microorganisms:

• urogenital infections (acute cystitis, urethritis, pyelonephritis);
• skin and soft tissue infections;
• severe infected burns;
• gynecological infections;

Prophylactically, it can be used for urological operations, cystoscopy, catheterization, etc.

Contraindications

• hypersensitivity to nitrofuran group drugs;
• pregnancy;
• breast-feeding;
• severe chronic renal failure;
• children under 3 years of age (for this dosage form).

With caution: renal failure, glucose-6-phosphate dehydrogenase deficiency.

Side effects

Furamag is low-toxic. Rarely observed side effects characteristic of other nitrofurans: headache, dizziness, nausea, vomiting, loss of appetite, polyneuritis, liver function disorders, allergic reactions (skin rash, papular rashes).

If during treatment with Furamagom side effects are found that are not specified in this description, then you should inform your doctor.

Interaction

Furamag should not be used simultaneously with ristomycin, chloramphenicol, or sulfonamides (the risk of hematopoiesis suppression increases). During the treatment period, it is advisable to refrain from drinking alcoholic beverages, as side effects may increase.

It is not recommended to prescribe simultaneously with nitrofurans drugs that can “acidify” the urine (including ascorbic acid, calcium chloride).

How to take, course of use and dosage

Inside, after eating, with plenty of fluids.

Adults – 50-100 mg (2-4 capsules of 25 mg or 1-2 capsules of 50 mg) 3 times a day.

Children — 25-50 mg (1-2 capsules of 25 mg) 3 times a day, but not more than 5 mg / kg / day.

The course of treatment is 7-10 days; if necessary, the course is repeated in 10-15 days.

For the prevention of infection during urological operations, cystoscopy, catheterization, etc. – adults 50 mg; children-25 mg once 30 minutes before the procedure.

If the next dose is not taken, you should take the next one at the usual time. You can not take a double dose to replace the missed one.

Overdose

Symptoms: in case of overdose, neurotoxic symptoms, ataxia and tremor are observed.

Treatment: in case of poisoning, you should drink a large amount of liquid. Antihistamines are used to relieve acute symptoms. For the prevention of neuritis, vitamins (thiamine bromide) can be prescribed.

Special instructions

To reduce the likelihood of side effects, Furamag is washed down with a large amount of liquid.

If side effects occur, the drug is discontinued (toxic effects are more often manifested in patients with reduced excretory function of the kidneys).

Influence on the ability to drive a car or perform work that requires an increased rate of physical and mental reactions. Not checked.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Furazidine

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

For adults as prescribed by a doctor, for children as prescribed by a doctor

Indications

Pharyngitis, Oral inflammation, Infectious diseases, Urethritis, Periodontitis, Wounds, Inflammation of the female genital organs, Burns, Stomatitis