Grammidin children’s spray for local use 0.03mg + 0.1mg/dose 112 doses, 1pc

Composition

1 dose:

gramicidin C dihydrochloride 0.0638 mg, which corresponds to the content of gramicidin C 0.03 mg, cetylpyridinium chloride 0.1 mg

Auxiliary substances:

ethanol 96% – 9.5 mg,

sucralose-0.2 mg,

glycerol-33.2 mg,

raspberry flavor-0.4 mg,

citric acid monohydrate-0.058 mg,

sodium citrate-0.022 mg,

polysorbate

80-0.4 mg, methyl parahydroxybenzoate-0.184 mg,

propyl parahydroxybenzoate-0.02 mg,

purified water – up to 0.2 ml

Pharmacological action

Combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity. The composition of the drug includes the antimicrobial agent gramicidin C and an antiseptic agent-cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of a microbial cell, which violates its stability and causes death. Gramicidin C has an antibacterial effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic that inhibits the growth and reproduction of pathogens of infectious diseases of the oral cavity and throat. The drug has an antimicrobial effect, reduces inflammation, softens unpleasant sensations in the throat, facilitates swallowing. Pharmacokinetics: A local drug. According to preclinical pharmacokinetic studies, absorption is practically absent.

Indications

Infectious and inflammatory diseases of the mouth and throat: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.

Contraindications

hypersensitivity to gramicidin C, cetylpyridinium chloride and other components of the drug;

lactation period;

children under 6 years of age.

Side effects

Possible allergic reactions to the components of the drug. If you experience any of the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, please reporttell your doctor about it.

Interaction

Currently, there are no cases of clinically significant interactions with other drugs.

How to take, course of use and dosage

Topically, by spraying on the mucous membrane of the mouth and throat. It is applied after meals. Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using the drug, you should refrain from eating and drinking for 1 hour. If there is no improvement after treatment, or if the symptoms worsen or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Overdose

Symptoms: the use of the drug in doses exceeding the recommended ones may cause gastrointestinal disorders: nausea, vomiting, diarrhea. Treatment:  you should stop using the drug and consult a doctor.

Description

Clear or opalescent, colorless or yellowish solution with a characteristic raspberry smell.

Special instructions

Do not use the drug in the presence of open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing. The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.04 g.

Form of production

Spray for topical application dosed 0.03 mg + 0.1 mg / dose. 112 doses each in aluminum vials equipped with a dosing device and a pressure device with a folding cannula. 1 bottle together with the instructions for use in a cardboard pack.

Storage conditions

In the original packaging at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Gramicidin C, Cetylpyridinium chloride

Dosage form

Tablets