Griseofulvin, pills 125mg, 20pcs

Composition

Active ingredient:

griseofulvin 125 mg

Pharmacological action

Griseofulvin is an antifungal antibiotic.

It has a fungistatic effect.

Active against dermatophytes of the genera Trichophyton, Microsporum, and Epidermophyton.

Inhibits cell division of fungal cells in metaphase, disrupting the structure of the mitotic spindle.

Griseofulvin accumulates to varying degrees in the cells of the skin, hair and nails, which are precursors of keratin, making keratin resistant to fungal invasion.

As infected keratin separates, it is replaced with healthy tissue.

Indications

Mycoses of the skin, hair and nails, etc.

Contraindications

Hypersensitivity, systemic lupus erythematosus, liver and kidney diseases.

Side effects

From the central nervous system:  headache, dizziness, disorientation, unusual fatigue or weakness, insomnia, peripheral neuropathy, impaired coordination of movements, paresthesia of the limbs, confusion.

From the gastrointestinal tract:  nausea, vomiting, diarrhea, gastralgia, candida stomatitis, hepatitis.

From the side of hematopoietic organs:  granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions:  urticaria, skin rash, pruritus, angioedema, photosensitization, lupus-like syndrome, erythema multiforme, Lyell’s syndrome.

Interaction

Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, indirect anticoagulants (due to the induction of microsomal liver enzymes).

Barbiturates and primidone reduce antifungal activity.

How to take, course of use and dosage

Inside, during or after a meal with vegetable oil.

With microsporia, children are prescribed at the rate of 21-22 mg per 1 kg of body weight of the patient per day, adults – from 500 to 1000 mg (8 tablets per day).

The drug is taken daily until the first negative test for fungi, then in the same dose every other day for 2 weeks and then 2 times a week for 2 weeks.

With trichophytosis (superficial and infiltrative suppurative forms) and favus in children — at the rate of 18 mg/kg of body weight according to the same scheme as with microsporia.

For onychomycosis, trichophytosis and favus of the scalp, the daily dose for adults weighing up to 50 kg is 625 mg (5 tablets) The maximum daily dose is 1 g (8 tablets).

The daily dose in children and adolescents is 16 mg / kg of body weight.

For onychomycosis, the drug is prescribed daily for the first month, every other day for the second month, then 2 times a week in the same daily dose until the nails grow back completely.

The total duration of treatment is at least 8 months.

Special instructions

Treatment with Griseofulvin is carried out under the control of the morphological composition of the blood (1 time in 10-15 days).

Form of production

Tablets

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf

life 3 years 6 months

Active ingredient

Griseofulvin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Children as prescribed by a doctor, Children over 3 years of age, Adults as prescribed by a doctor

Indications

Skin Fungus, Scalp Fungus, Nail Fungus Fungus and