Helmindazole pills 100mg, 6pcs

Composition

• Active ingredient:
• mebendazole (in terms of 100% substance) – 100.0 mg.
• Auxiliary substances:
• corn starch-72.0 mg,
• colloidal silicon dioxide-3.0 mg,
• talc-3.0 mg, magnesium stearate-3.0 mg,
• crospovidone-3.0 mg,
• sodium lauryl sulfate-0.5 mg,
• lactose monohydrate-to obtain a tablet weighing 300.0 mg

Pharmacological action

Helmindazolol is a broad-spectrum anthelmintic drug that is most effective in treating enterobiosis and trichocephalosis. Causing irreversible disruption of glucose utilization, it depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Indications

Enterobiosis, ascariasis, hookworm disease, strongyloidosis, trichocephalosis, trichinosis, teniosis, echinococcosis, multiple nematodes, alveococcosis, capillariasis, gnathostomosis, mixed helminthiasis.

Contraindications

Hypersensitivity to Mebendazole, ulcerative colitis, Crohn’s disease, liver failure, childhood (up to 2 years), pregnancy, lactation.

Side effects

Allergic reactions: skin rash, urticaria, angioedema, Stephen-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions. Hematopoietic disorders: neutropenia. From the digestive system: nausea, vomiting, abdominal pain, diarrhea, increased activity of “liver” transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time). Nervous system disorders: dizziness, headache, drowsiness, convulsions. From the urinary system: hypercreatininemia, glomerulonephritis (when used in high doses for a long time). Other: hair loss (when used in high doses for a long time).

Interaction

Reduces the need for insulin in diabetic patients. It should not be used simultaneously with lipophilic substances. Cimetidine may increase the concentration in the blood, carbamazepine and other inducers of metabolism – lower, and therefore it is necessary to monitor the concentration of drugs in the blood serum. Concomitant use of mebendazole and metronidazole should be avoided.

How to take, course of use and dosage

Inside with a small amount of water. Adults and children over 3 years old. For enterobiosis – once 100 mg / day (1 tablet); the course of treatment is 1 day. Since reinfection with enterobiosis is quite common, treatment should be repeated after 2 and 4 weeks. Simultaneous treatment of all family members is recommended. For ascariasis, trichocephalosis, hookworm and mixed helminthiasis: 200 mg / day (1 tablet in the morning,1 tablet in the evening); the course of treatment is 3 days. With teniosis, strongyloidosis. Adults: 400 mg / day (2 tablets in the morning,2 tablets in the evening); the course of treatment is 3 days. Children over 3 years of age: 200 mg / day (1 tablet in the morning,1 tablet in the evening); the course of treatment is 3 days. With echinococcosis. Adults and children over 14 years of age: in the first three days,500 mg 2 times a day, in the next 3 days, the dose is increased to 500 mg 3 times a day; in the future, the dose is increased to 1000-1500 mg 3 times a day. The average duration of treatment for echinococcosis caused by Echinococcus granulosis is 4-6 weeks, and for Echinococcus multilocularis-up to two years. With trichinosis on the 1st day 3 times a day for 200-300 mg, on the 2nd day 4 times a day for 200-300 mg, and from the 3rd to the 14th day – 3 times a day for 500 mg.

Overdose

Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible liver function disorders, hepatitis, neutropenia. Treatment: it is necessary to remove the drug from the stomach, causing vomiting or gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

The drug contains lactose, so this drug is contraindicated in patients with rare hereditary problems of lactose intolerance, lactase deficiency, or impaired glucose/galactose absorption. In patients with diabetes mellitus, it is necessary to monitor the concentration of glucose in the blood plasma. With prolonged use, it is necessary to monitor the picture of peripheral blood, liver and kidney function. During the day after taking it, the use of ethanol, fatty foods, and laxatives is prohibited. Periodic examination of anal and fecal smears is mandatory after the end of treatment: therapy is considered effective in the absence of helminths or their eggs for the next 7 days. The results of a study of the development of Stephen-Johnson syndrome and toxic epidermal necrolysis indicate a possible link between their occurrence and the simultaneous use of mebendazole and metronidazole. There are no other data documenting cases of such drug interactions. That is why the simultaneous use of mebendazole and metronidazole should be avoided. Effects on the ability to drive vehicles and mechanisms Patients should exercise caution when driving vehicles and working with machinery, as dizziness and drowsiness may occur during treatment.

Storage conditions

In a place protected from moisture and light at a temperature not exceeding 25°C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Mebendazole

Conditions of release from pharmacies

By prescription

Description

Children as prescribed by a doctor, Adults as prescribed by a doctor, Children over 3 years of age

Indications

Worms