Imunofan suppositories rectal 90mcg, 5pcs

Composition

Suppositories for rectal use 1 supp. imunofan 100 mcg

excipients:

purified water;

glycine;

solid fat;

tween 80

Pharmacological action

Imunofan is a detoxifying, hepatoprotective, antioxidant, and immunomodulatory agent.

Pharmacodynamics

The drug has an immunoregulatory, detoxifying, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. It corrects the state of the immune system, restores the balance of redox – antioxidant reactions of the body, and helps to overcome multiple drug resistance of tumor cells mediated by proteins of the cell’s transmembrane transport pump.

The effect of the drug begins to develop within 2-3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the rapid phase (duration — up to 2-3 days), the detoxification effect is primarily manifested — the body’s antioxidant defense is enhanced due to stimulation of the production of ceruloplasmin, lactoferrin, and catalase activity; the drug normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and arachidonic acid synthesis, followed by a decrease in blood cholesterol levels and the production of inflammatory mediators. In case of toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases and the level of bilirubin in the blood serum.

During the middle phase (starting in 2-3 days, lasting up to 7-10 days), phagocytosis reactions and the death of intracellular bacteria and viruses increase.

During the slow phase (begins to develop on 7-10 days, duration up to 4 months), the immunoregulatory effect of Imunofan® is manifested — restoration of impaired cellular and humoral immunity indicators. During this period, normalization of the immunoregulatory index is observed, and an increase in the production of specific antibodies is noted. The effect of the drug on the production of specific antiviral and antibacterial antibodies is equivalent to the effect of therapeutic vaccines. Unlike the latter, the drug does not significantly affect the production of reagin antibodies of the IgE class and does not enhance the immediate hypersensitivity reaction; Imunofan® stimulates the formation of IgA in its congenital insufficiency.

Imunofan ® effectively suppresses multiple drug resistance of tumor cells and increases their sensitivity to the action of chemotherapeutic drugs.

Indications

• For adults and children over 2 years of age (prevention and treatment):
• immunodeficiency and toxic conditions;
• chronic inflammatory diseases of various etiologies.
• For adults — as an adjuvant for vaccination against bacterial and viral infections.

Use during pregnancy and lactation

Due to insufficient knowledge, it should be used with caution during pregnancy and lactation.

Contraindications

Hypersensitivity; children under 2 years of age.

Side effects

Possible: individual intolerance, allergic reactions.

Interaction

Increases the effectiveness of other types of drug therapy: the use of imunofan helps to overcome resistance to glucocorticoid therapy.

use of the drug is possible in combination with anti-inflammatory steroid and non-steroidal anti-inflammatory drugs.

How to take, course of use and dosage

Rectally. Single dose and daily dose-100 mcg (0.1 mg) 1 suppository.

• In the treatment of cancer patients in the scheme of radical combined treatment (chemo-radiation therapy and surgery)

  Once a day, the course of treatment is 8-10 suppositories before chemo-radiation therapy and surgery, followed by continuation of the course throughout the entire treatment period.

• In patients with advanced tumor process (stage III – IV) of various localization in the form of complex or symptomatic therapy

  Once, daily, the course of treatment is 8-10 suppositories, with a break of 15-20 days and repeated courses throughout the entire period of subsequent treatment.

• In children with malignant diseases of hematopoietic and lymphoid tissue

  , once a day, daily, the course of treatment is 10-20 suppositories. use of the drug should be carried out during the entire course of chemo-radiation therapy and after the end of the course to prevent the development of toxicosis.

• In the complex therapy of children with pappylomatosis of the larynx and oropharynx

  1 time a day, daily, the course of treatment is 10 suppositories.

• For opportunistic infections (cytomegalovirus and herpetic infection, toxoplasmosis, chlamydia, pneumocystis, cryptosporidiosis)

  1 time a day, daily, the course of treatment is 15-20 suppositories.

• In the complex therapy of HIV infection

  1 time a day, daily, the course of treatment is 15-20 suppositories. If necessary, repeat courses should be conducted in 2-4 weeks.

• With chronic viral hepatitis and chronic brucellosis

  , once a day, daily, the course of treatment is 15-20 suppositories, to prevent relapse, repeated courses should be carried out after 2 to 3 months.

• With diphtheria

  1 time a day, daily, the course of treatment is 8-10 suppositories. With diphtheria bacterial carrier – 1 time in 3 days – 3-5 suppositories.

• In the treatment of burns of the III-IV degree with the phenomena of toxemia, septicotoxemia, in surgical patients with septic endocarditis, long-term non-healing wounds of the extremities, purulent-septic complications

  1 time a day, daily, the course of treatment is 7-10 suppositories, if necessary, the course of the drug should be continued up to 20 suppositories.

• With broncho-obstructive syndrome, cholecystopancreatitis, rheumatoid arthritis

  1 time in 3 days, the course of treatment is 8-10 suppositories, if necessary, the course should be continued up to 20 suppositories with the same interval.

• In the treatment of psoriasis

  1 time a day, daily, the course of treatment is 15-20 suppositories.

• In adults in the vaccine prevention scheme

  Once a day of vaccination.

Special instructions

As a result of activation of phagocytosis, a short-term exacerbation of foci of chronic inflammation, supported by the persistence of viral or bacterial antigens, is possible.

Form of production

Rectal suppositories.

Storage conditions

The drug is stored in a place protected from light at a temperature of 2°C to 10°C, out of the reach of children. It is not recommended to use the drug after the expiration date indicated on the package.

Shelf

life is 2 years.

Active ingredient

Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine

Conditions of release from pharmacies

By prescription

Dosage form

rectal suppositories