Ingaron lyophilisate of intranasal injection solution 100kMe vial, 1pc

Composition

Active ingredient:

interferon gamma 100kIU (5,5±0,5);

Auxiliary substances:

mannitol

Pharmacological action

Ingaron® – recombinant human interferon gamma, consists of 144 amino acid residues (a. o. ), deprived of the first three a. o. — Cys-Tyr-Cys, replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. Specific antiviral activity on cells (human fibroblasts) infected with the vesicular stomatitis virus is 2 * 107 U / mg of protein.

Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine, which is produced in the human body by natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Macrophages, neutrophils, natural killer cells, and cytotoxic T-lymphocytes have interferon gamma receptors.

Interferon gamma activates the effector functions of these cells, in particular their microbocidicity, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals, thereby causing the death of intracellular parasites. Interferon gamma inhibits the B-cell response, IL-4, and suppresses IgE production and CD23 antigen expression. It is an inducer of apoptosis of differentiated B cells that give rise to autoreactive clones. Cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and generation of lymphokinactivated killers. Activates the production of proteins of the acute phase of inflammation, increases the expression of the C2 and C4 genes of the complement system components.

Unlike other interferons, it increases the expression of both class 1 and class 2 major histocompatibility complex (HSCC) antigens on different cells, and induces the expression of these molecules even on cells that do not express them constitutively. This increases the efficiency of antigen presentation and the ability of T-lymphocytes to recognize them.

Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins, and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.

Interferon gamma blocks the synthesis of β-TGF, which is responsible for the development of lung and liver fibrosis.

Indications

Complex therapy for the prevention and treatment of influenza and avian influenza (H5N1 and H1N1).

Use during pregnancy and lactation

Ingaron is contraindicated during pregnancy

Contraindications

• individual intolerance to interferon gamma or any other component of the drug;
• pregnancy;
• children under 7 years of age.

How to take, course of use and dosage

Intranasally. The contents of the vial are dissolved in 5 ml of water for injection.

At the first signs of flu, ARVI — 2 drops in each nasal passage, after the toilet of the nasal passages,5 times a day for 5-7 days.

For the prevention of acute respiratory viral infections and influenza in case of contact with the patient and / or hypothermia — 2-3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days. If necessary, the preventive courses are repeated. With a single contact, one instillation is sufficient.

After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.

Form of production

Lyophilizate for preparation of solution for intranasal use

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Ready solution in the refrigerator (do not freeze). Keep out of reach of children.

Shelf life

2 years

Active ingredient

Human recombinant interferon gamma

Dosage form

nasal drops

Indications

Eczema, Atopic Dermatitis, Joint Pain