Irunin, capsules 100mg, 6pcs

Composition

1 capsule contains:

Active ingredient:

itraconazole;

Auxiliary substances:

sucrose,

starch,

hydroxypropylmethylcellulose,

poloxamer.

Pharmacological action

Itraconazole is a triazole derivative.

Irunin inhibits (disrupts) the synthesis of ergosterol, which is an important component of the fungal cell membrane, which causes the antifungal effect of the drug.

Irunin is active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), yeast fungi Candida spp. (including Candida albicans, Candida glabrata, Candida krusei), mold fungi (Cryptococcus neoformans, Aspergillus spp., Histoplasma spp., Paracoccidioides brasiliensis, Sporothrix schenckii, Fonsecaea spp., Cladosporium spp., Blastomyces dermatidis).

Indications

• ringworm;
• fungal keratitis;
• the onychomycosis caused by dermatophytes and/or yeasts and molds;
• systemic mycoses systemic aspergillosis and candidiasis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis, and other system or tropical mycoses;
• kandidomikoz with a lesion of the skin or mucous membranes, including vulvovaginal candidiasis;
• deep visceral candidiasis;
• pityriasis versicolor.

Use during pregnancy and lactation

During pregnancy and lactation, the drug Irunin is prescribed only in cases where the expected effect of treatment exceeds the possible risk of side effects.

Contraindications

Hypersensitivity to the drug or its components.

Side effects

The most frequently reported adverse reactions associated with the use of itraconazole were gastrointestinal reactions such as dyspepsia, nausea, abdominal pain and constipation.

In addition, there were: anorexia, headache, fatigue, reversible increase in liver enzyme activity, cholestatic jaundice, hepatitis, menstrual disorders, dizziness and allergic reactions (such as pruritus, rash, urticaria and angioedema), peripheral neuropathy, Stevens-Johnson syndrome, alopecia, hypokalemia, edema, congestive heart failure and pulmonary edema, dark staining of urine, hypercreatininemia.

In very rare cases, the use of Irunin has resulted in severe toxic liver damage, including cases of acute liver failure with a fatal outcome.

How to take, course of use and dosage

The drug Irunin is prescribed orally immediately after eating, the capsules are swallowed whole.

For vaginal candidiasis, the drug is prescribed at a dose of 200 mg 2 times a day for 1 day or at a dose of 200 mg 1 time a day for 3 days. For fungal skin diseases – 100 mg 1 time a day for 15 days.

For oral candidiasis – 100 mg once a day for 15 days.

 For fungal nail diseases, Irunin is prescribed at a dose of 200 mg / day for 3 months or repeated courses of 200 mg 2 times a day for 1 week with subsequent breaks (pulse therapy).

 For fungal diseases of internal organs-200 mg 1 time a day for 2-7 months, if necessary, the dose of Irunin is increased to 200 mg 2 times a day.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Itraconazole

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

Adults as prescribed by a doctor

Indications

Thrush