Katena capsules 300mg, 100pcs

Composition

Composition of one capsule: Active ingredient: gabapentin-300 mg; auxiliary components: corn starch, lactose monohydrate, talc; capsule shell:  gelatin, titanium dioxide (E 171), as well as iron oxide yellow dye E 172 (in capsules of 300 mg), iron oxide yellow dye E 172 and iron oxide red E 172 (in capsules of 400 mg).

Pharmacological action

The Active ingredient of Katena is gabapentin, a substance similar in structure to the neurotransmitter gamma-aminobutyric acid (GABA). However, its mechanism of action differs from that of some other drugs that interact with GABA receptors, including barbiturates, GABA uptake inhibitors, GABA agonists, valproate, GABA transaminase inhibitors, benzodiazepines and prodrug forms of GABA, since gabapentin does not have GABA-ergic properties, does not affect the metabolism and uptake of GABA. According to preliminary studies, gabapentin binds to the α2-δ subunit of voltage-dependent calcium channels and suppresses the flow of calcium ions, which is one of the causes of neuropathic pain. In addition, in neuropathic pain, gabapentin has other mechanisms of action, namely: it reduces glutamate-dependent neuronal death, increases GABA synthesis, and suppresses the release of monoamine group neurotransmitters. In clinically significant concentrations, the drug does not bind to the receptors of other common drugs and neurotransmitters, including benzodiazepines, glutamate, glycine, N-methyl-D-aspartate, GABA and GABA. Unlike carbamazepine and phenytoin, gabapentin does not interact with sodium channels.

Indications

• epilepsy;
• neuropathic pain;
• convulsive seizures.

For the treatment of convulsive seizures, the drug is used as part of complex therapy. The drug is well tolerated. The drug Katena is recommended for use in patients of the adult age category.

for adults

Patients of this age group can use the drug composition when identifying the above-mentioned indications for use. In some cases, the drug is well tolerated and adverse reactions against the background of its use are extremely rare. The appearance of adverse reactions may be due to the patient’s non-compliance with the basic rules and regulations for taking the composition.

for children

The drug Katena can be used in pediatric practice if there are strict medical indications for use. Taking medication is prohibited for patients under the age of 6 years. Patients over the age of 6 years can use the remedy as prescribed by a doctor to eliminate convulsive seizures. People over the age of 12 years use the composition for the treatment of epilepsy.

for pregnant women and lactation

During breastfeeding and during pregnancy, caution should be exercised when using the medication. For pregnant women, the drug is prescribed only in cases where the benefits of treatment are several orders of magnitude higher than all the potential risks to the process of fetal formation in the womb. Breastfeeding should be discontinued for the duration of therapy for nursing patients.

Recommendations for use

The capsule should be swallowed and washed down with water. The drug can be taken at any time, regardless of the meal.

for adults

A single dose is 100 mg, and the frequency of use is determined by the doctor. The permissible daily amount is calculated based on individual tolerance and the body’s response to treatment. The dose increases gradually.

Treatment of epilepsy is long-term, in most cases, lifelong.

In the treatment of patients over 12 years of age, effective results can be achieved with the use of 900 mg of gabapentin per day. First, the minimum dose is prescribed, increasing it to the required one every 3 days. The daily amount is usually divided into three doses. The maximum interval between taking tablets should not be more than 12 hours. If it is necessary to replace the drug or completely cancel it, the dose reduction should occur gradually. Treatment of neuropathic pain begins with taking 300 mg of gabapentin three times a day. Further, the dose is adjusted by the doctor and can be gradually increased to 3600 mg

. for children

Therapeutic dosages for children over 12 years of age coincide with prescriptions for adult patients.

The expediency of using the composition for young children is determined by the doctor.

for pregnant women and lactation

During pregnancy and lactation, this composition should not be used, since its active components are absorbed into breast milk and actively overcome the placental barrier.

Contraindications

The main list of contraindications to the use of the composition includes the following restrictions: :

• age of the child under 12 years;
• lactose intolerance;
• lactase deficiency;
• hypersensitivity to the Active ingredient or other elements of the drug composition;
• pregnancy;
• lactation period;
• pancreatic dysfunction (including acute pancreatitis);
• glucose-galactose malabsorption;
• various kidney failures.

If any contraindications are identified, taking the composition is prohibited.

Side effects

Against the background of taking the medication, the following reactions may occur: :

• diplopia;
• leukopenia;
• depression;
• confusion;
• fluctuations in blood pressure;
• myalgia and arthralgia;
• increase in bone fragility;
• tremor;
• fever;
• loss of coordination of movements;
• insomnia or drowsiness;
• purpura;
• aggressiveness and anxiety;
• the strengthening, weakening or absence of tendon reflexes;
• dizziness and headache;
• myalgia;
• pain in the abdomen and back;
• impotence;
• allergic skin reactions;
• blurred vision;
• swelling;
• dyspeptic reactions;
• increased appetite;
• emotional lability;
• cough.

The occurrence of these reactions is often considered as a reason for refusing subsequent therapy.

Interaction

In combination with oral contraceptives, the composition does not affect their effectiveness.

The bioavailability of the drug may be slightly reduced when taken simultaneously with antacids based on magnesium and aluminum. To avoid an undesirable decrease in therapeutic activity, an interval of two hours should be observed between doses.

The concentration in the blood can increase morphine. When taking these drugs at the same time, their doses should be adjusted.

When used simultaneously with antacids, the intensity of absorption of the Active ingredient from the gastrointestinal tract decreases.

Overdose

Against the background of a significant excess of doses, the patient may have the following reactions: :

• drowsiness;
• diarrhea;
• dizziness;
• speech and visual disturbances.

To improve the patient’s well-being, the use of sorbents and gastric lavage is indicated. Exceeding the dose by more than 20 times can cause a fatal outcome.

The use of the drug should be carried out under the supervision of a specialist. Uncontrolled use of the drug is unacceptable due to the high risks for the patient.

Special instructions

Patients with diabetes should consult their doctor about adjusting the dosage of hypoglycemic medications.

Throughout the entire course of using Katen, it is necessary to monitor the patient’s mental state, since the drug can cause the development of depressive and suicidal moods.

It is extremely important to follow the doctor’s prescribed dosage regimen to prevent the occurrence of acute adverse reactions.

Abrupt discontinuation of the drug may cause a convulsive status.

If it is necessary to reduce the dose, consult a doctor to work out an adequate regimen.

Patients taking medication are not recommended to drive motor vehicles.

Active ingredient

Gabapentin

Conditions of release from pharmacies

By prescription

Dosage form

Capsules