Kestine, pills 10mg, 10pcs

Composition

Active ingredient:

Ebastine microionized 10 mg.

Auxiliary substances:

microcrystalline cellulose,

corn starch,

lactose monohydrate,

sodium carboxymethylcellulose structured,

magnesium stearate,

hydroxypropylmethylcellulose,

polyethylene glycol 6000,

titanium dioxide.

Pharmacological action

Pharmaceutical group: anti-allergic agent-H1-histamine receptor blocker.

Pharmaceutical action: Long-acting histamine H1-receptor blocker. Prevents histamine-induced smooth muscle spasms and increased vascular permeability. After taking the drug inside, a pronounced anti-allergic effect develops in 1 hour and continues for 48 hours. After a 5-day course of treatment with Kestine, antihistamine activity persists for 72 hours due to the action of active metabolites.

The drug does not cause significant anticholinergic and sedative effects. There was no effect of Kestine on the duration of the QT interval on the ECG, even at a dose of 80 mg.

Indications

Allergic rhinitis of various etiologies (seasonal and/or year-round, both accompanied and not accompanied by allergic conjunctivitis).

Urticaria of various etiologies, including chronic idiopathic.

Use during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Contraindications

• Hypersensitivity to the components of the drug;
• pregnancy and lactation;
• children under 12 years of age;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Caution: use in patients with prolonged QT interval, hypokalemia, renal and / or hepatic insufficiency.

Side effects

With a frequency of more than 1%: headache (7.9%), drowsiness (3.0%), dryness of the oral mucosa (2.1%).

With a frequency of less than 1%: dyspepsia, nausea, insomnia, abdominal pain, asthenic syndrome, sinusitis, rhinitis.

Interaction

It is not recommended to use Kestine® concomitantly with ketoconazole and erythromycin (increased risk of prolongation of the QT interval).

Kestine® does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

How to take, course of use and dosage

Inside, regardless of food intake.

• Adults and children over 12 years of age: prescribe 10-20 mg (1-2 tablets) of the drug once a day.

If liver function is impaired, the daily dose should not exceed 10 mg.

Overdose

Symptoms: signs of moderate effects on the central nervous system (fatigue) and the autonomic nervous system (dryness of the oral mucosa) can occur only at high doses (300 mg-500 mg, which is 30-50 times higher than the therapeutic dose).

Treatment: There is no specific antidote for Ebastine. In case of overdose, gastric lavage, monitoring of vital body functions, and symptomatic treatment are recommended.

Special instructions

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

In the event of side effects from the central nervous system, a minimal decrease in the ability of patients to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions is possible.

Form of production

Film-coated tablets

Storage conditions

In a dark place, at a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Abastin

Dosage form

Tablets

Description

Children over 12 years old, For adults

Indications

Urticaria, Allergic Conjunctivitis, Allergic Rhinitis, Allergy