Kipferon suppositories vaginal and rectal 200mg+500000IU, 10pcs

Composition

Active ingredients:

immunoglobulin complex preparation (CIP) – 0.2 g,

human Interferon alfa-2b,

recombinant-500,000 IU;

Auxiliary substances:

fat special purpose “Solpro” confectionery

for chocolate products and candies – 0,838 g,

paraffin oil solid P-2 – of 0.085 g,

emulsifier “Hard” (T-2) – of 0.085 g,

sodium hydrogen phosphate, dodecahydrate – 0,055 mg,

sodium dihydrogen phosphate dihydrate – 0,018 mg,

sodium chloride – 0,110 mg,

purified water – 0.012 g

Pharmacological action

Kipferon is a complex dosage form containing human recombinant interferon-α2 and a complex immunoglobulin preparation (CIP). Interferon-α2 is an activator of innate and acquired immunity, has a pronounced antiviral activity, enhances protection against viral, chlamydial, mycoplasma and bacterial infections, has an immunomodulatory effect in the development of immunological reactions, promotes the growth and preservation of intestinal and vaginal normoflora.

The biological activity of interferon-α2 is realized through interaction with the receptor apparatus of immunocompetent and other cells, which leads to increased expression of HLA I and HLA II molecules on the surface of all cell types and regulation of cell cooperation, increased activity of natural killers, as well as giving intact cells resistance against their cytolytic action, CD8 T cell proliferation. Increases the production of gamma interferon by natural killers. Complex immunoglobulin preparation KIP contains specific and non-specific immunoglobulins of classes G, M, A.

The combination of antiviral, antichlamydial, antibacterial and antitoxic antibodies belonging to various classes of immunoglobulins provides agglutination, neutralization and precipitation of etiotropic pathogenic agents. At the site of application, it provides stabilization of interferon from mucosal secretions, normalizes local immunity due to the intake of IgA and IgM with suppositories (replacement effect), increases the activity of locally formed cytokines.

Indications

The drug is used in the complex therapy of diseases accompanied by secondary immunodeficiency conditions:

• acute respiratory diseases, inflammatory diseases of the oropharynx bacterial and viral etiology in children and adults;
• acute viral (rotavirus) and bacterial (Salmonella, dysentery, if) infection of intestinal infection, including manifestations of intestinal dysbacteriosis of different severity in children;
• urogenital chlamydia in women (including pregnant women in the II-III trimester of pregnancy), including manifestations of vaginal dysbiosis, candidiasis, cervicitis uterus, cervical erosion.

Contraindications

Individual intolerance of individual components, pregnancy I trimester, lactation period.

How to take, course of use and dosage

Kipferon is used rectally and vaginally. The drug is used in combination with conventional means of pathogenetic therapy of infectious diseases, as well as antibiotics for indications. The method and dosage regimen, as well as the use in complex treatment, is determined by the doctor depending on the diagnosis, severity and severity of the disease.

Acute respiratory diseases, inflammatory diseases of the oropharynx of bacterial and viral etiology: suppositories are administered rectally (mainly after the act of defecation) to children under 1 year of age, one suppository per day, children under 12 years of age – 1 suppository twice a day, adults and children over 12 years of age – 1 suppository three times a day. The most effective and appropriate appointment of “Kipferon” in the acute period of the disease (preferably in the first 3 days). The duration of the course of treatment is determined by the etiology, severity of the disease, the presence of concomitant complications, pathological conditions and is 5-7 days.

Acute viral (rotavirus) and bacterial (salmonellosis, dysentery, coli infection) intestinal infections, including those with manifestations of intestinal dysbiosis of various severity in children: suppositories are administered rectally (mainly after the act of defecation) to children under 1 year of age, one suppository per day, children under 12 years of age-1 suppository twice a day, adults and children over 12 years of age – 1 suppository three times a day. It is most effective and expedient to prescribe the drug in the acute period of the disease (preferably in the first 3 days). The duration of the course of treatment is determined by the etiology, severity of the disease, the presence of concomitant complications, pathological conditions and is 5-7 days.

Urogenital chlamydia in women (including pregnant women in the II-III trimesters of pregnancy), including those with manifestations of vaginal dysbiosis, vulvovaginitis, uterine cervicitis, and cervical erosion: suppositories are administered deeply intravaginally (before contact with the posterior vault of the vagina and cervix) 1-2 suppositories, depending on the severity of the disease, twice a day. The course of treatment is on average 10 days; in the presence of cervical erosion, the drug is continued until its epithelialization. If indicated, the course of treatment can be repeated in one month. Treatment should begin in the first days after the end of menstruation. Before use, it is recommended to remove mucus from the mucous membranes of the vagina and cervix.

Special instructions

When used in the recommended doses, the drug does not affect the behavior or functional indicators of the body, as well as does not affect the ability to drive vehicles, mechanisms.

Form of production

Vaginal and rectal suppositories.

Storage conditions

Store in a dry place, protected from light, at a temperature of 2-8 °C.

Shelf

life is 1 year.

Active ingredient

Human immunoglobulin normal [IgG, IgM, IgA], Interferon alfa-2b

Dosage form

rectal suppositories