Lancid, 30mg capsules, 30pcs

Composition

1 capsule contains:

Active Ingredient:

Lansoprazole – 15 mg or 30 mg.

Composition of the capsule containing lansoprazole-30 mg (body):  

Gelatin – 38.9575 mg, sodium lauryl sulfate-0.0376 mg, propyl parahydroxybenzoate-0.37(30 mg. methyl parahydroxybenzoate-0.0940 mg, titanium dioxide-0.7120 mg, crimson dye [Ponceau 4R] – 0.0078 mg. water – 6.8150 mg.

Composition of the capsule containing lansoprazole-30 mg (cap):  

Gelatin-24.0376 mg. sodium lauryl sulfate-0.0232 mg, propyl parahydroxybenzoate-0.0580 mg, methyl parahydroxybenzoate-0.2320 mg, titanium dioxide-0.4393 mg, crimson dye [Ponceau 4R] – 0.0048 mg. water – 4.2050 mg.

Composition of black ink:  ethanol – 29-33%, isopropanol-9-12%, butanol-4-7%, shellac-24-28%, iron oxide black dye-24-28%. water ammonia-1-3%, propylene glycol 0.5-2%.

Pharmacological action

Lancid is an anti-ulcer agent.

It inhibits H+ – K+ATPase (proton pump) of parietal cells, blocks the final stage of hydrochloric acid formation, and suppresses basal and stimulated secretion.

Pharmacodynamics

Having high lipophilicity, it easily penetrates into the parietal cells of the stomach, concentrates in them, has a cytoprotective effect, increases the secretion of bicarbonates. Inhibition of the formation of hydrochloric acid at a dose of 30 mg is 80-97%. It does not affect the motility of the gastrointestinal tract. The inhibitory effect increases in the first four days of use. Secretory activity is restored 3-4 days after discontinuation of the drug.

Pharmacokinetics

Absorption is high. _Cmax after oral use at a dose of 30 mg is reached in 1.5-2.2 hours and is 0.75-1.15 mg/l. Binding to plasma proteins is 98%. T_1/2 — 1,3–1,7 h (increases with impaired renal function and in the elderly). It is actively metabolized during its primary passage through the liver. It is excreted by the kidneys in the form of metabolites (14-23%), as well as by the intestines.

Indications

Peptic ulcer of the stomach and duodenum, reflux esophagitis, erosive and ulcerative lesions of the stomach and duodenum with NSAIDs or associated with Helicobacter pylori (as part of complex therapy), stress ulcers, Zollinger-Ellison syndrome.

Use during pregnancy and lactation

Contraindicated. Breast-feeding should be discontinued for the duration of treatment.

Contraindications

Hypersensitivity, hepatic and / or renal failure, pregnancy, breast-feeding, childhood.

Side effects

Nervous system and sensory disorders:  headache, dizziness, drowsiness, in some cases — depression.

From the digestive tract:  diarrhea, abdominal pain, constipation.

Allergic reactions:  skin rashes.

Respiratory system disorders:  rhinitis, pharyngitis.

Other services:  myalgia

The interaction

slows down the elimination of drugs metabolized in the liver by microsomal oxidation (including diazepam, phenytoin, indirect coagulants). Antacids slow down and reduce absorption.

How to take, course of use and dosage

Inside, in the morning before meals. Capsules should be swallowed whole, without chewing.

Duodenal ulcer (in the acute stage):  30 mg / day for 2-4 weeks. (in resistant cases-up to 60 mg / day).

Peptic ulcer of the stomach (in the acute stage) and erosive-ulcerative esophagitis: 30-60 mg / day for 4-8 weeks.

Erosive and ulcerative lesions of the gastrointestinal tract on the background of taking NSAIDs:  30 mg / day for 4-8 weeks.

Eradication of Helicobacter pylori: 30 mg 2 times a day for 10-14 days in combination with antibacterial agents.

Anti-relapse treatment of gastric and duodenal ulcers:  30 mg/day.

Anti-relapse treatment of reflux esophagitis: 30 mg / day for a long time (up to 6 months).

Zollinger-Ellison syndrome:  the dose is selected individually until the basal secretion level is >10 mmol / h.

Special instructions

Before starting treatment, it is necessary to exclude the presence of a malignant process in the upper gastrointestinal tract.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C.

Shelf life

2 years

Active ingredient

Lansoprazole

Conditions of release from pharmacies

By prescription

Dosage form

Capsules