Linex Forte, capsules 28pcs

Composition

1 capsule contains:

Active Ingredient:

Probio-tec AB Blend 64 powder (Probio-tec® AB Blend 64) – 60,000 mg (the powder contains active ingredients:  Lactobacillus acidophilus (LA-5) – 13.8 mg and Bifidobacterium animalis subsp. lactis (BB-12) – 4.2 mg;

auxiliary components: dextrose anhydrous-29.1 mg, microcrystalline cellulose-6 mg, potato starch 6 mg, magnesium stearate-0.9 mg).

Auxiliary substances:  Beneo Synergy 1 – 171,500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose)); magnesium stearate-3,500 mg.

Capsule body composition:  hypromellose – 33.149 mg, titanium dioxide (E 171) – 0.691 mg.

Capsule cap composition:  hypromellose – 22.080 mg, titanium dioxide dye (E 171) – 0.240 mg, iron oxide yellow dye (E 172) – 0.240 mg

Pharmacological action

Linex ® Forte normalizes the intestinal microflora.

One capsule of Linex ® Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12)), each capsule contains 109 colony-forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal component of the natural intestinal microflora.

Main functions of lactic acid bacteria:

– protective: synthesis of substances with antibacterial activity;

– enzyme-producing: hydrolysis of fiber, proteins, fats, starch, bile acid deconjugation synthetic: synthesis of B vitamins, C, K, amino acids, organic acids, etc.

Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:

the decrease of the pH in the intestine (the result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);

– production of metabolites that have toxic effects against pathogenic bacteria (formation of H 2 O 2);

– education of antimicrobial substances, bacteriocins (LA-5 secretes acidosis, bacteriocin with broad spectrum of action, which inhibits the growth of bacteria and fungi);

– competition with pathogenic bacteria for nutrients;

– interaction with adhesion receptors, thus preventing the colonization of other potentially pathogenic microorganisms.

Pharmacokinetics:

Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract; when taken orally, the drug does not undergo systemic absorption. Standard pharmacokinetic studies are therefore not applicable. The resistance of LA-5 and BB-12 to gastric juice and bile allows the strains to survive in large numbers when passing through the stomach and duodenum 12. Both strains attach to the intestinal mucosa. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.

Indications

Treatment and prevention of intestinal dysbiosis.

Intestinal dysbiosis is manifested by the following symptoms: diarrhea( diarrhea), dyspepsia (digestive disorders), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.

Contraindications

-Hypersensitivity to the components of the drug;

– hereditary fructose intolerance, sucrose, isomaltase deficiency or glucose-galactose malabsorption.

With caution:

With caution in case of diabetes mellitus (simple sugars are included in the composition), insufficiency of the immune system (for example, HIV infection).

Diarrhea in children under 6 years of age should be treated under the supervision of a doctor.

Side effects

The drug is well tolerated. There are no reports of adverse effects, but hypersensitivity reactions may occur.

Interaction

No undesirable interactions with other drugs were observed.

With simultaneous use of antibiotics, the recommended interval between taking the drug (antibiotic) and Linex® Forte capsules is 3 hours.

How to take, course of use and dosage

Linex ® Forte capsules should preferably be taken during or after a meal with a small amount of liquid.

Adults and adolescents over 12 years of age:  take 1 capsule 1-3 times a day.

Children from 2 to 12 years old:  take 1 capsule 1-2 times a day.

Newborns and children under 2 years of age:  take 1 capsule 1 time a day.

Diarrhea in children under 6 years of age should be treated under the supervision of a doctor.

When prescribing Linex ® Forte to children and patients who cannot swallow a whole capsule, it must be opened, the contents poured into a spoon and mixed with a small amount of liquid.

The duration of treatment depends on the cause of dysbiosis and the individual characteristics of the body. Linex ® Forte can be taken until the symptoms of dysbiosis disappear.

Do not exceed the recommended daily dose of the drug.

Special instructions

Do not drink Linex® Forte with hot drinks and take it simultaneously with alcohol.

You should consult your doctor before taking this medicine if you have:

– body temperature above 38 °C;

– traces of blood or mucus in the stool;

– diarrhea lasts more than two days and is accompanied by acute abdominal pain, dehydration and weight loss;

– chronic diseases – diabetes mellitus, HIV infection.

When treating diarrhea, it is necessary to replace the lost fluid and electrolytes.

SPECIAL PRECAUTIONS WHEN DISPOSING OF AN UNUSED MEDICINAL PRODUCT

There is no need for special precautions when disposing of unused Linex® Forte.

Influence on the ability to drive vehicles and mechanisms:

The drug has no effect on driving vehicles and controlling mechanisms.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

2 years

Active ingredient

Lactobacilli acidophilus, Bifidobacteria BB 12

Dosage form

Capsules