Magnerot pills 500mg, 20pcs

Composition

Active ingredient:

magnesium orotate dihydrate 500 mg;

Auxiliary substances:

colloidal silicon dioxide-2.5 mg;

sodium carmellose-10 mg;

MCC-67.5 mg;

corn starch-22.5 mg;

povidone K 30-30 mg;

lactose monohydrate-50 mg;

sodium cyclamate-1.5 mg;

talc-18.75 mg;

magnesium stearate-1.63 mg;

Pharmacological action

Magnerot is a magnesium preparation. Magnesium is a macronutrient, essential for many energy processes, and is involved in the metabolism of proteins, fats, carbohydrates, and nucleic acids.

Magnesium takes part in the process of neuromuscular excitation, inhibiting neuromuscular transmission. Magnesium is of particular interest as a natural physiological calcium antagonist. Magnesium controls the normal functioning of myocardial cells, participates in the regulation of contractile function of the myocardium. In stressful situations, an increased amount of free ionized magnesium is removed, and therefore an additional amount of magnesium contributes to an increase in stress resistance.

Magnesium deficiency leads to neuromuscular disorders (motor and sensory hyperexcitability, seizures, paresthesia), mental changes (depression, confusion and hallucinations), cardiovascular diseases (ventricular extrasystole, tachycardia, hypersensitivity to cardiac glycosides). Magnesium deficiency during pregnancy increases the likelihood of toxicosis and premature birth. Orotic acid salts are involved in the process of metabolism. In addition, orotic acid salts are necessary for the fixation of magnesium on ATP in the cell and the manifestation of its action.

Pharmacokinetics

Approximately 35-40% of the dose is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts improves the absorption of magnesium. Magnesium is excreted by the kidneys, and excretion decreases when magnesium is deficient and increases when it is excess.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as increased irritability, minor sleep disturbances, gastrointestinal spasms, increased fatigue, muscle aches and spasms, and tingling sensation in the muscles. If after a month of treatment there is no reduction in these symptoms, continuation of treatment is impractical.

Use during pregnancy and lactation

It is possible to use the drug during pregnancy and lactation (breastfeeding )according to indications, since during these periods the need for magnesium increases significantly.

If its content is not balanced, it can lead to serious complications, including miscarriage.

The use of the drug during pregnancy and lactation is possible if the potential benefit to the mother exceeds the potential risk to the fetus and child.

Contraindications

• hypersensitivity to the components of the drug;
• impaired renal function;
• urolithiasis;
• predisposition to the formation of calcium-magnesium-ammonium-phosphate stones;
• cirrhosis of the liver with ascites;
• lactose intolerance;
• lactase deficiency;
• glucose-galactose malabsorption;
• children under 18 years of age.

Side effects

The frequency of occurrence of adverse reactions cannot be determined based on the available data. Disorders of the gastrointestinal tract:  unstable stools and diarrhea that go away on their own when the dose of the drug is reduced. From the immune system:  allergic reactions. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Concomitant use of magnesium-containing drugs with iron, sodium fluoride and tetracyclines may decrease the absorption of the latter. In addition, aminoquinolines, quinidine, penicillamine should not be administered simultaneously with magnesium preparations. Therefore, you should take these medications at intervals of 2-3 hours. Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, and insulin reduce the effect of the drug. Magnesium should be used with caution if you are taking magnesium-containing medications, such as antacids or laxatives, or potassium-sparing diuretics or medications containing calcium. When used concomitantly with drugs containing aluminum, the absorption of aluminum in the body can be increased. Magnesium should be used with caution when used concomitantly with digitalis preparations, as concomitant use may impair the absorption of digitalis preparations. Some antibiotics (aminoglycosides), cisplatins, and cyclosporine A may lead to increased magnesium excretion. Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B may cause magnesium deficiency and thus reduce the effect of Magnerot®.

How to take, course of use and dosage

Inside, before meals, with a small amount of liquid.

Assign 2 tablets 3 times a day for 7 days, then-1 tablet 2-3 times a day daily.

The course duration is at least 4-6 weeks. If necessary, Magnerot® can be used for a long time.

For nocturnal cramps of the calf muscles, it is recommended to take 2-3 tablets in the evening.

Overdose

With normal renal function, ingestion of magnesium does not cause toxic reactions. Magnesium poisoning can occur with kidney failure. Toxic effects mainly depend on the concentration of magnesium in the blood serum. Symptoms: low blood pressure, nausea, vomiting, depression, slow reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome. Treatment: rehydration, forced diuresis, with renal failure, hemodialysis or peritoneal dialysis is necessary.

Description

White or almost white round flat tablets with chamfers on both sides and a risk on one side.

Functional features

Approximately 35-40% of the dose is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts improves the absorption of magnesium. Magnesium is excreted by the kidneys, and excretion decreases when magnesium is deficient and increases when it is excess.

Special instructions

Magnerot® can be used for a long time.

It should be borne in mind that magnesium deficiency in the body can lead to gastrointestinal diseases, consumption of foods with a reduced magnesium content, sports (due to increased sweating), chronic alcoholism (due to a decrease in magnesium resorption in the renal tubules and increased removal of magnesium ions from the body), taking certain drugs (cardiac glycosides, aminoglycoside antibiotics, oral contraceptives, diuretics, laxatives, corticosteroids), conditions requiring increased consumption magnesium deficiency (hypodynamia, stress, pregnancy and lactation), prolonged exposure to the sun.

Influence on the ability to drive a car or perform work that requires an increased rate of physical and mental reactions. The drug does not affect the ability to drive vehicles and other activities that require high concentration of attention and speed of psychomotor reactions.

Composition

Tablet Form of production

Storage conditions

At a temperature not exceeding +25 °C. Keep out of reach of children.

Shelf

life is 5 years. Do not use after the expiration date.

Active ingredient

Magnesium Orotate

Dosage form

Tablets

Description

For adults, For pregnant women as prescribed by a doctor, For Nursing mothers as prescribed by a doctor

Indications

Muscle Spasm, Magnesium Deficiency, Myocardial Infarction, Atherosclerosis, Arrhythmia, Prevention of heart attacks and strokes