Magnesium sulfate, ampoules 25%, 10ml, 10pcs

Composition

Active ingredient:

magnesium sulfate

Pharmacological action

When administered parenterally, it has an anticonvulsant, antiarrhythmic, hypotensive, antispasmodic effect, in large doses it inhibits neuromuscular transmission, has a tocolytic effect, and suppresses the respiratory center. Mg2+ is a “physiological” BMCC and is able to displace it from the binding sites.

Regulates metabolic processes, inter-neuronal transmission and muscle excitability, prevents the flow of Ca2+ through the presynaptic membrane, reduces the amount of acetylcholine in the peripheral nervous system and central nervous system. Relaxes smooth muscles, reduces blood pressure (mainly elevated), increases diuresis.

Anticonvulsant effect-Mg2+ reduces the release of acetylcholine from neuromuscular synapses, while suppressing neuromuscular transmission, and has a direct depressing effect on the central nervous system.

Antiarrhythmic effect – Mg2+ reduces the excitability of cardiomyocytes, restores ion balance, stabilizes cell membranes, disrupts the Na+ current, slow incoming Ca2+ current and one-way K+current.

The cardioprotective effect is due to the expansion of the coronary arteries, a decrease in OPSS and platelet aggregation. Tocolytic action-Mg2+ inhibits the contractility of the myometrium (reducing the absorption, binding and distribution of Ca2+ in smooth muscle cells), increases blood flow in the uterus as a result of its vasodilation. It is an antidote for poisoning with heavy metal salts.

Systemic effects develop almost instantly after intravenous use and 1 h after intravenous use. The duration of action with intravenous use is 30 minutes, with intravenous use – 3-4 hours.

Indications

• hypertensive crisis;
• late toxicosis of pregnant women;
• convulsive syndrome.
• relief of epileptic status (as part of complex therapy).

Contraindications

• hypersensitivity to the drug;
• AV block;
• hypotension;
• conditions accompanied by calcium deficiency, respiratory depression.

Side effects

Early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden “rush” of blood to the skin of the face, headache, decreased blood pressure, nausea, shortness of breath, blurred speech, vomiting, asthenia.

Signs of hypermagnesemia, ranked in order of increasing serum Mg2+ concentration: decreased deep tendon reflexes (2-3.5 mmol/L), prolongation of the P-Q interval and expansion of the QRS complex on the ECG (2.5-5 mmol/L), loss of deep tendon reflexes (4-5 mmol/L), respiratory depression (5-6.5 mmol/L), cardiac conduction disorders (7.5 mmol/L), cardiac arrest (12.5 mmol/l). mmol / l).

In addition, hyperhidrosis, anxiety, deep sedation, polyuria, uterine atony.

Interaction

Enhances the effect of others. Drugs that depress the central nervous system. Cardiac glycosides increase the risk of conduction disturbances and AV block (especially with simultaneous intravenous use of Ca2+salts).

Muscle relaxants and nifedipine enhance neuromuscular blockade. With the combined use of magnesium sulfate for parenteral use with other vasodilators, the hypotensive effect may increase. Barbiturates, narcotic analgesics, antihypertensive drugs increase the likelihood of respiratory depression. It disrupts the absorption of tetracycline antibiotics, weakens the effect of streptomycin and tobramycin.

Ca2+ salts reduce the effect of magnesium sulfate Pharmacologically incompatible (forms a precipitate) with Ca2+ preparations, ethanol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, sodium hydrocortisone succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates. At concentrations of Mg2+ above 10 mmol/ml in mixtures for complete parenteral nutrition, separation of fat emulsions is possible.

How to take, course of use and dosage

In / m or iv. Magnesium sulfate is used only as prescribed by a doctor. Doses are specified taking into account the therapeutic effect and the concentration of magnesium sulfate in the blood serum.

When hypertensive crises are administered intravenously or intravenously slowly,5-20 ml of a 25% solution. In convulsive syndrome, spastic states, the drug is prescribed in / m for 5-20 ml of a 25% solution in combination with anxiolytic agents that have a pronounced central muscle relaxant effect.

In acute poisoning with mercury, arsenic, tetraethyl lead,5-10 ml of 5-10% magnesium sulfate solution is administered intravenously.

Overdose

Symptoms:  possible respiratory depression, depression of the central nervous system, up to the development of anesthesia.

Treatment:  as an antidote for an overdose of magnesium sulfate, calcium preparations are used-calcium chloride or calcium gluconate.

Product form

solution for injection

Storage conditions

At a temperature not exceeding 30 °C (do not freeze)

Shelf life

3 years

Active ingredient

Magnesium Sulfate

Conditions of release from pharmacies

By prescription

Dosage form

infusion solution