Mezym 20000 pills, 20pcs

Composition

Core:

Active ingredient:  Pancreatin* with minimal activity:

amylase 12000

UNITS lipase 20000 UNITS

protease 900 UNITS

Auxiliary substances: microcrystalline cellulose (type 12), crospovidone (type A), colloidal anhydrous silicon dioxide, magnesium stearate, lactose monohydrate.

Shell: hypromellose, methacrylic acid and ethyl acrylate copolymer (1: 1), dispersion 30% (dry weight), triethyl citrate, titanium dioxide, E 171, talc, simethicone emulsion 30% (dry weight), vanilla flavor, bergamot flavor, macrogol 6000, carmellose sodium, polysorbate 80, hydroxide.

* obtained from porcine pancreas

Pharmacological action

Pharmacotherapeutic group:  Digestive enzyme remedy

ATX code: A 09 AA 02

Pharmacological properties

Pharmacodynamics .  Pancreatin is a powder from the pancreas of pigs. Pancreatic enzymes, which are part of pancreatin, have proteolytic, amylolytic and lipolytic effects and contribute to the breakdown of proteins, fats and carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing the digestive processes.

Pharmacokinetics. Tablets of the preparation Mezym ® 20000 are covered with an acid-resistant shell, which is resistant to the effects of hydrochloric acid of the stomach and, thereby, protects the pancreatic enzymes contained in the preparation from inactivation. The intestinal membrane dissolves and the enzymes are released at neutral or slightly alkaline pH values.

Indications

• Insufficiency of external secretory function of the pancreas (chronic pancreatitis, cystic fibrosis, etc. );
• Chronic inflammatory and dystrophic diseases of the stomach, intestines, liver, and gallbladder;
• Conditions after resection or irradiation of the gastrointestinal tract, accompanied by digestive disorders, flatulence, diarrhea (as part of combination therapy);
• To improve food digestion in patients with normal gastrointestinal function in case of nutritional errors;
• Preparation for X-ray and ultrasound examination of the abdominal organs;
• Disorders of the gastrointestinal tract of a functional nature (with acute intestinal infections, irritable bowel syndrome, etc. ).

Use during pregnancy and lactation

Before using Mezym® 20000, if you are pregnant, or believe that you might be pregnant, or are planning to become pregnant, you should consult your doctor.

During breastfeeding, consult your doctor before using Mezym® 20000.

There are no data on the use of pancreatin during pregnancy and lactation.

During pregnancy and lactation, the use of pancreatin by the attending physician is possible only if the intended benefit to the mother exceeds the possible risk to the fetus or child.

Contraindications

• Hypersensitivity to any of the components of the drug;wbr>Acute pancreatitis or chronic pancreatitis in the acute stage. However, it is possible to use in the phase of fading exacerbation when expanding the diet, if there are signs of digestive disorders;
• Hereditary galactose intolerance, lactase deficiency, or glucose-galactose malabsorption syndrome;
• Children under 3 years of age (for this dosage form).
• Side effects

Possible side effects are listed below by descending frequency: very common (≥ 1/10), common (

>> 1/100, < 1/10), uncommon (>> 1/1000, < 1/100), rare (>> 1/10000, < 1/1000), very rare (Immune system disorders

Very rare:

allergic reactions of immediate type (such as skin rash, urticaria, sneezing, lacrimation, bronchospasm, dyspnoea), hypersensitivity of the gastrointestinal tract. Disorders of the gastrointestinal tract

Very rare:

diarrhea, abdominal discomfort, abdominal pain, nausea, vomiting; formation of strictures in the ileocecal and ascending parts of the colon in patients with cystic fibrosis with high doses of pancreatin. Disorders of the genitourinary system

Frequency unknown:

hyperuricosuria (see the section “Special instructions”). If you experience any of the side effects listed in the instructions or if they get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is possible to reduce the absorption of folic acid when used simultaneously with pancreatin preparations. The effect of hypoglycemic agents for oral use (such as acarbose, miglitol) may decrease when used simultaneously with preparations of digestive enzymes containing enzymes that break down carbohydrates (for example, amylase).

If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using Mezym ® 20000.

How to take it, course of use and dosage

The dose of Mezym ® 20000 is set individually depending on the disease and the severity of symptoms.

Unless otherwise indicated,

adults should take 1-2 tablets of Mezym ® 20000 with a meal. The drug is taken orally without breaking or chewing the tablet (the effectiveness of Mezym ® 20000 may decrease with chewing and pancreatic enzymes may irritate the oral mucosa when released), washed down with a sufficient amount of liquid (for example, a glass of water). It is not recommended to exceed the daily dose of pancreatic enzymes corresponding to 15000-20000 units of lipase/kg of body weight.

Increasing the dose should only be carried out under the supervision of a doctor, focusing on the symptoms (for example, reduction of steatorrhea and abdominal pain).

The duration of treatment is determined by the doctor and can vary from several days (in case of digestive disorders due to errors in the diet) to several months or even years (if permanent replacement therapy is required).

In

children, the dosage is determined by the doctor. Dosage for children and adults with cystic fibrosis

In patients with cystic fibrosis, the dose should be selected taking into account the severity of the symptoms of the disease, the results of steatorrhea control and maintaining an adequate nutritional status (see the section “Special instructions”).

The dose should not exceed 10,000 units of lipase/kg of body weight per day.

In

children, the dosage regimen and duration of treatment is set by the doctor depending on the severity of digestive disorders and the composition of the diet, at the rate of 1000 units of lipase/kg of body weight of the child for each meal for children under 4 years of age and 500 UNITS of lipase/kg of body weight of the child for each meal for children over 4 years. If there is no improvement after treatment, or if the symptoms worsen or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Overdose

Symptoms: hyperuricosuria and hyperuricemia (especially in patients with cystic fibrosis who take high doses of enzyme preparations).

Treatment: symptomatic therapy, drug withdrawal.

Description

round, biconvex coated tablets, white to white with a grayish tinge of color, with a smooth surface, with a specific smell, brown inclusions are possible on the fracture.

Special instructions

In case of acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during the period of restorative diet, it is advisable to take the drug Mezym ® 20000 against the background of existing and/or remaining exocrine pancreatic insufficiency.

Patients with cystic fibrosis, especially when taking high doses of pancreatin, may experience hyperuricosuria, so in this group of patients, it is necessary to monitor the concentration of uric acid in the urine.

Strictures in the ileocecal and ascending parts of the colon are described in the above group of patients.

As a precautionary measure, if you experience unusual abdominal discomfort or change in the nature of complaints, especially when taking more than 10,000 units of lipase/kg of body weight per day, a medical examination is necessary.

The preparation Mezym ® 20000 contains active enzymes that, when released in the oral cavity, for example, when chewed, can damage the oral mucosa (up to the formation of ulcers). Therefore, the tablet must be swallowed whole.

The drug contains lactose, so it is contraindicated in patients with hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

Influence on the ability to drive vehicles and mechanisms

The drug Mezym ® 20000 does not affect or has a slight effect on the ability to drive vehicles and other mechanisms.

Form of production

Enteric-soluble coated tablets,20000 units. 10 tablets in a contour cell pack (blister) [aluminum foil/aluminum foil].1,2 or 5 blisters with instructions for use in a cardboard box.

Storage conditions

At a temperature not exceeding 30 ° C. Keep out of reach of children!

Shelf

life is 3 years. Do not use after the expiration date indicated on the package.

Active ingredient

Pancreatin

Dosage form

Tablets

Purpose

Children over 3 years of age, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, For adults

Indications

Flatulence, Diet errors, Chronic pancreatitis, Preparation for ultrasound and abdominal X-rays, Overeating, Diarrhea