Midzo drops for oral use 60mg/ml 15ml dropper bottle, 4pcs

Composition

Active ingredient:

Cyanamide–60.0 mg;

Auxiliary substances:

Sorbic acid -0.2 mg,

acetic acid-0.47 mg,

sodium acetate trihydrate-0.47 mg,

purified water – up to 1.0 ml

Pharmacological action

Pharmacotherapy group: remedy for the treatment of chronic alcoholismacode ATX: V03AAPHARMACOLOGICAL propertiespharmacodynamicthe action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the concentration of the metabolite of ethyl alcohol – acetaldehyde, which causes negative sensations (flushes of blood to the face, nausea, tachycardia, shortness of breath, etc. ), which make it extremely unpleasant to drink alcohol after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages. The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram.

Indications

It is used to treat patients with chronic alcoholism and prevent relapses.

Contraindications

Severe heart diseases, respiratory tract and kidney diseases with reduced functions, severe liver diseases, pregnancy, breast-feeding, increased individual sensitivity to the drug.

Side effects

As a rule, the drug is well tolerated if alcohol is not consumed. Sometimes fatigue, drowsiness, skin rashes, tinnitus, and transient leukocytosis are possible.

Interaction

MIZO is not prescribed together with metronidazole, isoniazid, phenotoin and other aldehyde dehydrogenase inhibitors, which can increase the reaction with alcohol. After taking disulfiram, before prescribing MIZO, there should be a break of at least 10 days. Mizone is compatible with drugs of the aldehyde group (paraldehyde and chloral products).

How to take, course of use and dosage

Treatment is prescribed after a thorough examination of the patient and warnings about the consequences and complications. The drug is prescribed orally for 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual scheme.

Overdose

Symptoms of overdose are not described, possibly increased side effects. In case of taking too large doses of the drug, gastric lavage is recommended and symptomatic treatment is prescribed to maintain liver, respiratory and cardiovascular functions, as well as monitoring of the hematocrit index and, if necessary, blood transfusion.

Special instructions

Reaction to alcoholthe following symptoms appear when taking the drug with alcohol at the same time: severe hyperemia of the skin, “pulsation” in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, heavy sweating, chest pain. In the most severe cases – vomiting, low blood pressure, respiratory depression, collaptoid state. The nature and severity of symptoms depend on the amount of alcohol and medication taken. In severe cases, it is necessary to conduct symptomatic therapy aimed at maintaining the functions of the respiratory and cardiovascular systems, intravenous infusion of antihistamines. MIZO should only be used under the supervision of a doctor and with the patient’s knowledge. You may experience a reaction to alcohol contained in certain medications and foods. MIZOMozhno treatment should be started only after 12 hours from the last alcohol intake. Cyanamide should be used with caution in cases where a reaction to simultaneous intake with alcohol may entail a risk to the patient’s health: hyperthyroidism, diabetes mellitus, epilepsy, cardiovascular diseases, kidney diseases. With prolonged use, it is recommended to monitor the function of the thyroid gland at least once every six months.

Form of production

Drops for oral use

Storage conditions

Store in a dark place at a temperature not exceeding 25 C.

Keep out of the reach of children.

Shelf

life is 2 years.

Active ingredient

Cyanamide

Conditions of release from pharmacies

By prescription

Description

For adults as directed by your doctor

Indications

Alcoholism