Miramistin solution for external use 0.01% vial with applicator, 50ml

Composition

1 l contains:

Active ingredients:

benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate 100 mg

Auxiliary substances:  

purified water-up to 1 l

Pharmacological action

Miramistin® It has a broad spectrum of antimicrobial activity, including hospital strains that are resistant to antibiotics.

The drug has a pronounced bactericidal effect against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc. ), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., etc. ), aerobic and anaerobic bacteria determined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.

It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodotorula rubra, Torulopsis gabrata, etc. ) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc. ), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc. ), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.

It has an antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus, and others).

Miramistin ® acts on pathogens of sexually transmitted diseases (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae and others).

Effectively prevents infection of wounds and burns. Activates regeneration processes. It stimulates protective reactions at the site of application by activating the absorption and digestion functions of phagocytes, and potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. It does not damage granulations and viable skin cells, and does not inhibit marginal epithelialization.

It does not have a local irritant effect and allergizing properties.

Indications

For use in otorhinolaryngology:

• complex treatment of acute and chronic otitis media, sinusitis, tonsillitis, laryngitis, pharyngitis;
• complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis in children aged 3 to 14 years.

For use in dentistry:

• treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis;
• hygienic treatment of removable dentures.

For use in surgery and traumatology:

• prevention of suppuration and treatment of purulent wounds;
• treatment of purulent-inflammatory processes of the musculoskeletal system.

For use in obstetrics and gynecology:

• prevention and treatment of suppuration of postpartum injuries, perineal and vaginal wounds, postpartum infections;
• prevention and treatment of inflammatory diseases (vulvovaginitis, endometritis).

For use in kombustiology:

• treatment of superficial and deep burns of II and IIIA degrees;
• preparation of burn wounds for dermatoplasty.

For use in dermatology and venereology:

• treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, mycosis of the feet;
• individual prevention of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis, etc. ).

For use in urology:

• complex treatment of acute and chronic urethritis and urethroprostatitis of specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.

Recommendations for use

With purulent sinusitis – during the puncture, the maxillary sinus is washed with a sufficient amount of the drug.

Tonsillitis, pharyngitis and laryngitis are treated by gargling and / or irrigation with a spray nozzle 3-4 times a day. The amount of the drug for 1 rinse is 10-15 ml.

For stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity with 10-15 ml of the drug 3-4 times a day.

When used in surgery, traumatology, and kombustiology, the surface of wounds and burns is irrigated for preventive and curative purposes, wounds and fistula passages are loosely tamponed, and gauze swabs moistened with the drug are fixed. The treatment procedure is repeated 2-3 times / day for 3-5 days. The method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug is highly effective.

When used in obstetrics and gynecology for the prevention of postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), in childbirth after each vaginal examination and in the postpartum period,50 ml of the drug in the form of a tampon with an exposure of 2 hours, for 5 days. For the convenience of vaginal irrigation, the use of a gynecological nozzle is recommended. Insert the contents of the vial into the vagina with a gynecological nozzle and perform irrigation.

When delivering women by caesarean section, the vagina is treated immediately before the operation, the uterine cavity and incision are treated during the operation, and in the postoperative period, tampons moistened with the drug are inserted into the vagina with an exposure of 2 hours for 7 days. Treatment of inflammatory diseases is carried out in a course of 2 weeks by intra-vaginal injection of tampons with the drug, as well as by drug electrophoresis.

For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Use a urological applicator to insert the contents of the bottle into the urethra for 2-3 minutes: men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml). For convenience, it is recommended to use a gynecological nozzle. Treat the skin of the inner thighs, pubis, and genitals. After the procedure, it is recommended not to urinate for 2 hours.

In the complex treatment of urethritis and urethroprostatitis,2-3 ml of the drug is injected into the urethra 1-2 times / day, the course of treatment is 10 days.

In acute pharyngitis and/or exacerbation of chronic tonsillitis, the pharynx is irrigated with a spray nozzle. Children aged 3-6 years: for children aged 7-14 years, double-tap (5-7 ml per irrigation),3-4 times / day; for children over 14 years of age,3-4-tap (10-15 ml per irrigation),3-4 times/day; for children over 14 years of age, double-tap (10-15 ml per irrigation),3-4 times / day. The duration of therapy is from 4 to 10 days, depending on the time of remission.

Rules for using the drug

The drug is ready for use.

Instructions for using the package with the spray nozzle

1. Remove the cap from the bottle, and remove the urological applicator from the 50 ml bottle.

2. Remove the supplied spray nozzle from its protective packaging.

3. Attach the spray nozzle to the bottle.

4. Activate the spray nozzle by pressing again.

Instructions for using a 50 ml or 100 ml package with a gynecological nozzle

1. Remove the cap from the bottle.

2. Remove the supplied gynecological nozzle from its protective packaging.

3. Attach the gynecological nozzle to the bottle without removing the urological applicator.

Contraindications

Individual intolerance to the drug.

Side effects

Local reactions:  in some cases, a slight burning sensation may occur at the site of application, which passes on its own, after 15-20 seconds, and does not require discontinuation of the drug. Allergic reactions.

Interaction

When used concomitantly with antibiotics, their antibacterial and antifungal properties were enhanced.

How to take it, course of administration and dosage

The drug is ready for use.

Instructions for using the package with the spray nozzle:

Remove the cap from the bottle.

Remove the supplied spray nozzle from its protective packaging.

Attach the spray nozzle to the bottle.

Activate the spray nozzle by pressing again.

Surgery, traumatology, and kombustiology. For preventive and curative purposes, the surface of wounds and burns is irrigated, wounds and fistula passages are loosely tamponed, gauze swabs moistened with the drug are fixed. The treatment procedure is repeated 2-3 times a day for 3-5 days. The method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug is highly effective.

Obstetrics and gynecology. In order to prevent postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), in childbirth after each vaginal examination and in the postpartum period,50 ml of the drug in the form of a tampon with an exposure of 2 hours, for 5 days. When delivering women by caesarean section, the vagina is treated immediately before the operation, the uterine cavity and incision are treated during the operation, and in the postoperative period, tampons moistened with the drug are inserted into the vagina with an exposure of 2 hours for 7 days. Treatment of inflammatory diseases is carried out in a course of 2 weeks by intra-vaginal injection of tampons with the drug, as well as by drug electrophoresis.

Venereology. For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse.Use a urological applicator to insert the contents of the bottle into the urethra for 2-3 minutes: men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml). Treat the skin of the inner thighs, pubis, and genitals. After the procedure, it is recommended not to urinate for 2 hours.

Urology. In the complex treatment of urethritis and urethroprostatitis,2-3 ml of the drug is injected into the urethra 1-2 times a day, the course is 10 days.

Otorhinolaryngology. With purulent sinusitis – during the puncture, the maxillary sinus is washed with a sufficient amount of the drug. Tonsillitis, pharyngitis and laryngitis are treated by gargling and / or irrigation with a spray nozzle,3-4-fold pressing,3-4 times a day. The amount of the drug for one rinse is 10-15 ml.

Dentistry. For stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity with 10-15 ml of the drug,3-4 times a day.

Overdose

There are no data on overdose of Miramistin®.

Description

The solution for topical application is colorless, transparent, foaming when shaken.

Functional features

When applied topically, the drug does not have the ability to be absorbed through the skin and mucous membranes.

Form of production

The solution for topical application is colorless, transparent, foaming when shaken.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf

life is 3 years. Do not use the drug after the expiration date.

Active ingredient

Benzyldimethyl 3-(myristoylamino) propylammonium chloride monohydrate

Dosage form

solution for topical application

Purpose

For pregnant women, For children, For adults as prescribed by a doctor, For adults, For Nursing mothers

Indications

Eye Infections, Chlamydia, Laryngitis, Sinusitis, Purulent wounds, Oral Inflammation, Skin Infections, Otitis Media, Periodontitis, Disinfection, Tonsillitis, Urethritis, Sore Throat