Composition
Per 1 capsule: Active ingredient: simethicone – 120.00 mg; excipients: gelatin – 50,60 mg, glycerol-19,60 mg
Pharmacological action
Pharmacotherapy group: Â other medicinal products for the treatment of functional disorders of the gastrointestinal tract. ATX code: Â A 03 AH 13.
Pharmacological properties
Pharmacodynamics
Simethicone is a chemically inert polymer of methylsiloxane containing about 5% silicon dioxide.
Simethicone has defoaming and anti-foaming properties, significantly reduces the surface tension of purified water and model solutions of surfactants. The results of the defoaming experiments showed complete destruction of the foam within 3-6 seconds when adding a liquid suspension of simethicone at a concentration of 0.1 mg / ml. Below this threshold, the foam is not completely destroyed. As a defoamer, simethicone is also effective at a concentration of 0.1 mg / ml. This effect lasts for more than 24 hours.
The mechanism of action is based on the spread of silicone liquid over the surface of the foam film, as well as on a local change in surface tension in the contact area. Thus, rapid drainage of the liquid occurs, which contributes to the rupture of the film, as a result of which the released gas is able to be absorbed or removed naturally.
Pharmacokinetics
Simethicone is a chemically inert substance that has no physiological activity, it is not absorbed, passes through the digestive tract and is excreted unchanged.
Indications
Symptomatic treatment of flatulence (excessive gas formation and bloating) associated with disorders of the gastrointestinal tract – including those caused by functional dyspepsia.
Contraindications
Hypersensitivity to simethicone or other components of the drug, children under 18 years of age, intestinal obstruction.
Side effects
The frequency of adverse reactions is given in the following gradation: very common (≥1/10); common (≥1/100, <1/10); infrequent (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (According to post-marketing use data, gastrointestinal tract disorders: Very rare:  vomiting. Skin and subcutaneous tissue disorders: Very rare:  angioedema, rash, allergic reactions to the components of the drug. If you have any of the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
How to take, course of use and dosage
Inside. Take 1 capsule 3 times a day after meals with a small amount of water. The maximum daily dose is no more than 3 capsules (360 mg). If there is no improvement after treatment, or if symptoms worsen or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions for use.
Special instructions
If the medicine has become unusable or expired, do not throw it into the waste water or throw it on the street! Place the medicine in a plastic bag and put it in the trash can. These measures will help protect the environment!
Effect of the drug on the ability to drive vehicles, mechanisms
The drug does not affect the ability to drive vehicles or engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of reach of children.
Shelf
life is 3 years. Do not use the drug after the expiration date.
Active ingredient
Simethicon
Dosage form
Capsules
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Side effects of Motilegas Forte capsules 120mg, 40pcs.
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