Nasivin, nasal drops 0.01% 5ml

Composition

>1 ml of the drug contains:  Active substance:  Nasivin 0.01% – Oxymetazoline hydrochloride 0.1 mg Nasivin 0.025% – Oxymetazoline hydrochloride 0.25 mg Nasivin 0.05% – Oxymetazoline Hydrochloride 0.5 mg Excipients: benzalkonium chloride 50% solution, disodium edetate dihydrate, sodium dihydrogen phosphate dihydrate, sodium hydrophosphate dihydrate, sodium hydroxide 1 M solution, purified water.

Pharmacological action

Nasivin® (oxymetazoline) has a vasoconstrictive effect. When applied topically to the inflamed nasal mucosa, it reduces its puffiness and nasal discharge. Restores nasal breathing. Elimination of mucosal edema helps restore aeration of the paranasal sinuses, middle ear cavity, which prevents the development of bacterial complications (sinusitis, sinusitis, otitis media). When applied locally intranasally in therapeutic concentrations, it does not irritate the mucous membrane, does not cause hyperemia. With local intranasal use, the drug does not have a systemic effect. The drug begins to act quickly (within a few minutes). The duration of action of Nasivin is up to 12 hours.

Indications

• treatment of acute respiratory diseases accompanied by a runny nose;
• allergic rhinitis;
• vasomotor rhinitis;
• to restore drainage in case of inflammation of the paranasal sinuses, eustachiitis, otitis media; 
• to eliminate edema before diagnostic manipulations in the nasal passages.

Use during pregnancy and lactation

When used during pregnancy or lactation, do not exceed the recommended dosage. The drug should be used only after careful assessment of the risk-benefit ratio for the mother and fetus.

Contraindications

Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug. It is necessary to adhere to the recommended concentrations of the drug intended for different age categories (see methods of application). With caution In patients taking monoamine oxidase inhibitors and other drugs that increase blood pressure in the period up to 10 days after their use; with increased intraocular pressure, during pregnancy and lactation, with severe forms of cardiovascular diseases (hypertension, angina pectoris); with thyrotoxicosis and diabetes mellitus.

Side effects

Sometimes: burning or dryness of the nasal membranes, sneezing. In rare cases: after the effect of using Nasivin® has passed, a strong feeling of “stuffy” nose (reactive hyperemia). Repeated overdose with topical nasal use sometimes leads to such systemic sympathomimetic effects as increased heart rate (tachycardia) and increased blood pressure. In very rare cases, anxiety, insomnia, fatigue, headaches, and nausea were observed. Prolonged continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (drug-induced rhinitis).

Interaction

With simultaneous use of MAO blockers and tricyclic antidepressants-increased blood pressure. Co-use of other vasoconstrictor medications increases the risk of side effects.

How to take, course of use and dosage

Nasivin® 0.01%,0.025% and 0.05% drops are intended for use in the nose. Adults and children over 6 years of age: apply Nasivin® 0.05% drops 1-2 drops in each nasal passage 2-3 times a day. Children from 1 to 6 years of age: apply Nasivin® 0.025% drops 1 to 2 drops in each nasal passage 2 to 3 times a day. Children under 1 year of age: children under 4 weeks of age are prescribed 1 drop of Nasivin 0.01% in each nasal passage 2 to 3 times a day. From the 5th week of life to 1 year – 1-2 drops in each nasal passage 2-3 times a day. To ensure accurate dosage, the Nasivin® 0.01% drop bottle has a graduated pipette with drop count markings. For example, if 1 drop is prescribed, then the pipette should be filled with a solution up to mark 1. The following procedure is also proven to be effective: depending on the age,1-2 drops of 0.01% solution are applied to cotton wool and the nasal passages are wiped. Nasivin 0.01%,0.025% and 0.05% drops should be used for 3 to 5 days. Doses higher than recommended should only be administered under medical supervision.

Overdose

Symptoms (after a significant overdose or accidental ingestion): constriction of the pupils, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may occur, as well as depression of the central nervous system, accompanied by drowsiness, lowering body temperature, bradycardia, hypotension, respiratory arrest and possible coma.

Treatment:  gastric lavage, taking activated charcoal, and seeing a doctor immediately.

Special instructions

Long-term use and overdose of the drug should be avoided, especially in children. After long-term use or use of remedies for the common cold containing oxymetazoline, in dosages exceeding the recommended ones, the overall effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to drive a vehicle or equipment may be reduced.

Form of production

Nasal drops

Storage conditions

In a dark place, at a temperature not exceeding 25 °C.

Shelf life

3 years

Active ingredient

Oxymetazoline

Dosage form

nasal drops

Description

For children from birth

Indications

Flu, Allergic Rhinitis, Sinusitis, Pollinosis, Otitis Media, Cold, Runny Nose