Neurocholine solution 500mg/4ml 4ml ampoules, 5pcs

Composition

1 amp. citicoline sodium 522.5 mg, which corresponds to the content of citicoline 500 mg; Excipients:  sodium hydroxide 1 M or hydrochloric acid 1 M-up to pH 6.5-7.5, d/i water-up to 4 ml

Pharmacological action

Nootropic agent. Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.

In the acute period of stroke, it reduces the volume of damaged tissue, improves cholinergic transmission.

With traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms.

Citicoline improves the symptoms observed in hypoxia: memory loss, emotional lability, lack of initiative, difficulties in performing daily activities and self-care. It is effective in the treatment of cognitive, sensory and motor neurological disorders of degenerative and vascular etiology.

Indications

Ischemic stroke (acute period); ischemic and hemorrhagic stroke (recovery period); traumatic brain injury (acute and recovery period); cognitive impairment in degenerative and vascular diseases of the brain.

Contraindications

Vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system); children and adolescents under 18 years of age; hypersensitivity to citicoline.

Side effects

From the central nervous system and peripheral nervous system:  insomnia, headache, dizziness, agitation, tremor, numbness in paralyzed limbs.

From the digestive system:  nausea, decreased appetite, changes in the activity of liver enzymes.

Allergic reactions:  rash, itchy skin, anaphylactic shock.

Other services:  fever; in some cases-short-term hypotensive effect, stimulation of the parasympathetic nervous system.

The Citicoline interaction enhances the effects of L-dihydroxyphenylalanine.

How to take, course of use and dosage

When taken orally-200-300 mg 3 times / day.

IV for strokes and traumatic brain injury in the acute period-1-2 g / day, depending on the severity of the disease for 3-7 days, followed by switching to iv use or oral use.

In / m – 0.5-1 g / day.

Special instructions

Citicoline should not be used simultaneously with medications containing meclofenoxate.

Active ingredient

Citicoline

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as prescribed by a doctor, for pregnant women as prescribed by a doctor

Indications

Consequences of stroke, Acquired dementia, Concussion and other traumatic brain injuries