Opatanol, eye drops, 5ml

Composition

Active ingredient:

olopatadine hydrochloride 1.11 mg, (corresponds to 1.0 mg of olopatadine);

Auxiliary substances:  

benzalkonium chloride,

sodium chloride,

disodium phosphate dodecahydrate;

concentrated hydrochloric acid and / or sodium hydroxide (for pH adjustment),

purified water

Pharmacological action

Opatanol is an anti-allergic substance.

Pharmacodynamics

Olopatadine is a selective inhibitor of histamine_H1receptors and also inhibits the release of inflammatory mediators from mast cells. It has a pronounced anti-allergic effect.

It has no effect on alpha-adrenergic, dopamine, muscarinic type 1 and 2, as well as serotonin receptors.

Pharmacokinetics

When applied topically, systemic absorption is low. Cmax of_olopatadine in blood plasma is reached within 2 hours and ranges from 0.5 ng / ml or less to 1.3 ng / ml.

T_1/2 in plasma is 3 h. It is mainly excreted by the kidneys. 60-70% – unchanged.

Indications

Allergic conjunctivitis.

Use during pregnancy and lactation

There is no sufficient experience in using the drug during pregnancy and lactation. The use of the drug during pregnancy and lactation is possible if the expected therapeutic effect exceeds the potential risk to the fetus.

Application in pediatrics.

There is no sufficient experience in using the drug in children under 3 years of age. Opatanol can be used in pediatrics in children from 3 years and older in doses similar to adults.

Contraindications

Individual hypersensitivity to the components of the drug.

Side effects

Local users. In some cases (less than 5%): blurred vision, burning and pain in the eyes, lacrimation, foreign body sensation in the eye, conjunctival hyperemia, keratitis, iritis, swelling of the eyelids.

In 0.1–1% of cases, weakness, headache, dizziness, nausea, pharyngitis, rhinitis, sinusitis, and taste changes are noted.

In some cases (less than 5%): blurred vision, burning and pain in the eyes, lacrimation, foreign body sensation in the eye, conjunctival hyperemia, keratitis, iritis, swelling of the eyelids. In 0.1-1% of cases, weakness, headache, dizziness, nausea, pharyngitis, rhinitis, sinusitis, and taste changes are noted.

Interaction

If necessary, it can be used in combination with other topical ophthalmic medications. In this case, the interval between their use should be at least 5 minutes.

How to take, course of use and dosage

Locally. Take 1 drop 2 times a day in the conjunctival sac. Shake the bottle before use.

Overdose

If applied topically, overdose is unlikely. If an excessive amount of the drug gets into the eyes, it is recommended to rinse the eyes with warm water.

Special instructions

Before instillation of the drug, the lenses should be removed and replaced no earlier than 20 minutes after instillation of the drug, since Opatanol contains the preservative benzalkonium chloride, which can be absorbed by contact lenses.

Do not touch any surface with the tip of the pipette to avoid contamination of the solution.

If the patient’s vision is temporarily reduced after using the drug, it is not recommended to drive a car or engage in activities that require increased attention before it is restored.

Form of production

Opatanol. Eye drops.

Storage conditions

At a temperature of 4 to 30 °C.

Shelf

life is 3 years. After autopsy – 1 month.

Active ingredient

Olopatadine

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

For adults as prescribed by a doctor, Children as prescribed by a doctor, Children over 3 years old, Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Allergic Conjunctivitis, Allergy, Hay Fever