Indications
- trichomoniasis;
- amoebiasis: amoebic dysentery, extra-intestinal amoebiasis (including amoebic liver abscess);
- giardiasis;
- prevention of infections caused by anaerobic bacteria during operations on the colon and in gynecology.
$1.00
Active ingredient: | |
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Dosage form: | |
Indications for use: | Amoebiasis and giardiasis, Intestinal infections, Trichomoniasis |
Out of stock
With caution: diseases of the central nervous system (including epilepsy, multiple sclerosis), liver diseases, alcoholism, pregnancy, lactation.
Active ingredient:
ornidazole 500 mg;
Excipients:
lactose (milk sugar),
microcrystalline cellulose,
povidone (polyvinylpyrrolidone),
sodium lauryl sulfate,
calcium stearate,
colloidal silicon dioxide (aerosil),
primellose (sodium croscarmellose),
hypromellose (hydroxypropylmethylcellulose),
macrogol 4000 (polyethylene glycol 4000),
talc,
titanium dioxide
Active ingredient:
ornidazole 500 mg;
Auxiliary substances:
lactose (milk sugar),
microcrystalline cellulose,
povidone (polyvinylpyrrolidone),
sodium lauryl sulfate,
calcium stearate,
colloidal silicon dioxide (aerosil),
primellose (sodium croscarmellose),
hypromellose (hydroxypropylmethylcellulose),
macrogol 4000 (polyethylene glycol 4000),
talc,
titanium dioxide
Ornidazole is an antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole.
The mechanism of action consists in the biochemical reduction of the 5-nitro group of ornidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of ornidazole interacts with the DNA cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolitica, Lamblia spp., and obligate anaerobes Bacteroides spp. (including Bacteroides fraglis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P. bivia, P. buccae, P. disiens), and some Gram-positive microorganisms (Eubacterium spp., Clostridium). Aerobic microorganisms are not sensitive to ornidazole.
Pharmacokinetics
Absorption from the gastrointestinal tract is high, bioavailability is 90%. Binding to plasma proteins is less than 15%.
It is metabolized in the liver by hydroxylation, oxidation, and glucuronidation. T1 / 2 – 12-14 hours.
Penetrates into breast milk and most tissues, passes through the BBB and placenta. It is excreted as metabolites by the kidneys (60-70%) and with feces (20-25%), about 5% of the dose is excreted unchanged.
With caution: diseases of the central nervous system (including epilepsy, multiple sclerosis), liver diseases, alcoholism, pregnancy, lactation.
Drowsiness, headache, gastrointestinal disorders (including nausea), dizziness, tremor, muscle rigidity, impaired coordination of movement, convulsions, fatigue, temporary loss of consciousness, sensory or mixed peripheral neuropathy, perversion of taste sensations, changes in the activity of “liver” enzymes, allergic reactions.
Enhances the effect of coumarin-type anticoagulants, prolongs the muscle-relaxing effect of vecuronium bromide.
It is compatible with ethanol (does not inhibit acetaldehyde dehydrogenase), unlike other imidazole derivatives (metronidazole).
Ornidazole is prescribed orally after a meal.
With trichomoniasis: inside 1.5 g once or 1 g in combination with intravaginal use of 500 mg (vaginal tablets) at night. You can carry out treatment for 5 days, prescribing 1 tablet (500 mg) inside 2 times a day (morning and evening), also with the appointment of 1 vaginal tablet of 500 mg at night.
For amoebic dysentery: adults and children with a body weight of more than 35 kg – 1.5 g 1 time a day, with a body weight of more than 60 kg-2 g/day. Children with a body weight of 12-35 kg – 40 mg / kg / day. The course lasts for 3 days.
For the treatment of other forms of amoebiasis: adults and children over 12 years of age – 0.5 g orally in the morning and evening for 5-10 days.
With giardiasis: adults and children with a body weight over 35 kg – 1.5 g 1 time a day; children with a body weight of 12-35 kg-40 mg / kg / day. The duration of treatment is 1-2 days.
Prevention of infections caused by anaerobic bacteria: 0.5-1 g before surgery, after surgery-0.5 g 2 times a day for 3-5 days.
Symptoms: epileptiform seizures, depression, peripheral neuritis.
Treatment: symptomatic (diazepam – for convulsions).
Tablet Form of production
In a dry place, out of reach of children and protected from light, at a temperature not exceeding 25°C.
Ornidazole
By prescription
Tablets
Children as prescribed by a doctor, Adults as prescribed by a doctor, Children over 3 years of age, Pregnant women in the second and third trimester as prescribed by a doctor
Trichomoniasis, Intestinal infections, Amoebiasis and giardiasis
Out of stock
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