Pantogam Active, capsules 300mg, 60pcs

Composition

Active ingredient:

rac-hopantenic acid (D, L-hopantenic acid).

Auxiliary substances:  

microcrystalline cellulose ;

magnesium stearate.

Pharmacological action

Pantogam active – nootropic, anticonvulsant.

Pharmacodynamics

The effect of Pantogam activ® is associated with the presence of gamma – aminobutyric acid in its structure, which directly affects the GABAB-receptor – channel complex. Pantogam Active®is a racemic mixture of equal amounts of the R-form of hopantenic acid and its S-isomer.

The presence of the isomer improves the transport and interaction of the drug with the GABA receptor. Pantogam active® has a more pronounced nootropic and anticonvulsant effect than the first-generation hopantenic acid preparations.

Pantogam Active ® increases the brain’s resistance to hypoxia and toxic substances, stimulates anabolic processes in neurons, and combines a moderate sedative effect with a mild stimulating effect.

It has an anti-asthenic and mild anti-anxiety effect. Reduces motor excitability, regulates behavior. Activates mental activity and efficiency. Causes inhibition of pathologically elevated cystic reflex and detrusor tone.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract. Penetrates through the BBB. It is not metabolized and is excreted unchanged within 48 hours: about 70% of the dose taken — in the urine, about 30% – in the feces.

Indications

• Cognitive disorders in organic brain lesions (including the consequences of neuroinfections and traumatic brain injury) and neurotic disorders;
• cerebrovascular insufficiency caused by atherosclerotic changes in vessels of the brain;
• extrapyramidal hyperkinesis (myoclonus epilepsy, Huntington’s chorea, hepatolenticular degeneration, Parkinson’s disease, etc. ), treatment of extrapyramidal syndrome induced by neuroleptics;
• epilepsy (together with anticonvulsants);
• psycho-emotional overload, reduced mental and physical performance, to improve concentration and memory;
• neurogenic disorders of urination (pollakiuria, imperative urges, imperative urinary incontinence, enuresis);
• schizophrenia (in the complex therapy).

Contraindications

• Hypersensitivity;
• acute severe kidney disease;
• pregnancy (I trimester);
• breast-feeding period;
• patient’s age up to 18 years (there are no clinical studies on the use of the drug at an earlier age).

Side effects

In rare cases, allergic reactions (rhinitis, conjunctivitis, skin rashes) are possible.

In this case, reduce the dose or cancel the drug.

Sleep disorders or drowsiness, noise in the head — these symptoms are usually short-lived and do not require discontinuation of the drug.

Interaction

It prolongs the action of barbiturates, enhances the effects of anticonvulsants, and prevents the side effects of phenobarbital, carbamazepine, and neuroleptics.

The effect of Pantogam active® is enhanced when combined with glycine, ethidronic acid.

Potentiates the action of local anesthetics (procaine).

How to take, course of use and dosage

Inside,15-20 minutes after eating,2-3 times a day, preferably in the morning and afternoon hours.

The course of treatment is 1-4 months, sometimes up to 6-12 months. After 3-6 months, it is possible to conduct a second course of treatment.

Overdose

Symptoms:  increased side effects.

Treatment:  use of activated charcoal, gastric lavage, symptomatic therapy.

Special instructions

Before using, it is recommended to consult a specialist.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

D, L-hopanthenic acid

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

Pregnant women in the second and third trimester as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Neurosis, Schizophrenia, Enuresis, Epilepsy, Atherosclerosis, Concussion and other traumatic brain injuries, Parkinson ‘s Disease