Papaverine suppositories rectal 20mg, 10pcs

Composition

Composition per suppository: Active ingredient: Papaverine hydrochloride-20 mg; Excipients: Solid fat (Vitepsol (brands H 15, W 35), Supposir (brands NA 15, NAS 50) — – until a suppository weighing 1.25 g

is obtained Pharmacological action

Papaverine hydrochloride is a myotropic antispasmodic agent. Inhibits phosphodiesterase, causes accumulation of cyclic 3,5-adenosine monophosphate (AMP) in the cell and a decrease in calcium content. Relaxes smooth muscles of internal organs (gastrointestinal tract, respiratory tract, genitourinary system) and blood vessels. In large doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction. The effect of papaverine on the central nervous system is weak, but in large doses it has a sedative effect. Pharmacokinetics The bioavailability of papaverine after rectal use (according to preclinical studies) is about 25%. Binding to plasma proteins is 90%. It is well distributed and penetrates through histohematic barriers. It is metabolized in the liver. The half-life (T 1/2) is 0.5-2 hours (possibly increased to 24 hours). It is excreted by the kidneys in the form of metabolites.

Indications

• spasms (sharp narrowing of the lumen) of the brain vessels,
• angina pectoris,
• endarteritis (inflammation of the inner lining of the arteries),
• cholecystitis (inflammation of the gallbladder),
• pylorospasm (spasm of the muscles of the pylorus of the stomach),
• spastic colitis,
• spasm of the urinary tract,
• bronchospasm (narrowing of the lumen of the bronchi).

Contraindications

Hypersensitivity to the components of the drug, atrioventricular block, glaucoma, severe liver failure, elderly age (risk of hyperthermia), children’s age, because the dosage regimen in children is not specified. Cautiously and in small doses used in the condition after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.

Side effects

Possible:  

• nausea,
• constipation,
• drowsiness,
• excessive sweating,
• hypotension,
• increased activity of hepatic transaminases.

Interaction

Reduces the effect of dopegit.

When smoking, the effectiveness decreases.

How to take, course of use and dosage

Rectally. Having released the suppository from the contour package, it is inserted into the anus. Apply 1 suppository 2-3 times a day after spontaneous bowel movement or cleansing enema.

Special instructions

Use with caution and in small doses in elderly and debilitated patients, as well as in patients with traumatic brain injury, impaired liver and kidney function, hypothyroidism, adrenal insufficiency, prostatic hypertrophy, supraventricular tachycardia and shock.

During the treatment period, alcohol consumption should be excluded.

Form of production

Rectal suppositories

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf

life is 2 years. Do not use the product after the expiration date indicated on the package.

Active ingredient

Papaverine

Dosage form

rectal suppositories

Description

For adults, Children over 1 year old

Indications

Cholelithiasis, Colitis, Urolithiasis, Hypertension, Bronchospasm, Spasm of the gastrointestinal tract, Biliary dyskinesia, Cholecystitis