Phlebodia 600 pills 600mg, 15pcs

Composition

1 film-coated tablet contains:

Active ingredient:

diosmin (in terms of dry matter) 600 mg,

excipients:

talcum powder-10.24 mg;

colloidal silicon dioxide-3.5 mg;

stearic acid-50.05 mg;

MCC — up to 910 mg,

film shell:

Sepifilm 002 (hypromellose (E 464) — 9,832 mg, MKC — 7,866 mg, macrogol 8 stearate type 1 — 1,967 mg); Episperm AR 5523 pink (propylene glycol — traces, hypromellose (E 464) — 0,458 mg, titanium dioxide (E 171) — 4,026 mg, dye crimson [Ponceau 4R] (E 124) — 0,401 mg, iron oxide black (E 172) — 0.13 mg, iron oxide red (E 172) — 0.02 mg); Opalas 6000 (Carnauba wax (E 903) — 0.075 mg, beeswax (E 901) — 0.075 mg, shellac (E 904) — 0.15 mg, ethanol 95° — traces),

Pharmacological action

The drug Phlebodia 600 has a phlebotonic effect (reduces the extensibility of the veins, increases the tone of the veins (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of the lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and It improves the migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect.

Increases the vasoconstrictive effect of epinephrine, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, it is detected in plasma 2 hours after use. The maximum concentration in the blood plasma is reached 5 hours after use.

It is evenly distributed and accumulates in all layers of the wall of the vena cava and subcutaneous veins of the lower extremities, to a lesser extent-in the kidneys, liver, lungs and other tissues.

Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. It is excreted by the kidneys 79%, intestines-11%, with bile-2.4%.

Indications

As part of complex therapy:

• elimination of symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain;
• additional treatment for microcirculation disorders;
• acute hemorrhoids (symptomatic therapy).

Use during pregnancy and lactation

So far, no side effects have been reported in clinical practice when using the drug in pregnant women. Use during pregnancy in the second and third

trimesters is possible only as prescribed by a doctor in cases where the expected benefit to the mother exceeds the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, because there are no data on the penetration of the drug into breast milk.

Contraindications

• hypersensitivity to the components of the drug Phlebodia 600;
• breast-feeding period;
• pregnancy (I trimester – limited experience);
• children (under 18 years of age).

Side effects

In rare cases-hypersensitivity to the components of the drug (requiring a break in treatment).

Gastrointestinal disorders: dyspeptic disorders (heartburn, nausea, abdominal pain).

From the central nervous system: headache.

If any of the described side effects get worse, or the patient notices any other side effects that are not listed in the description, you should inform your doctor.

Interaction

Clinically significant interaction effects with other drugs have not been described.

How to take, course of use and dosage

Before using the drug, you should consult your doctor.

The drug is intended for oral use.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), I tablet is prescribed per day in the morning on an empty stomach.

The duration of therapy is usually 2 months. In case of exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets a day with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug in the usual mode and in the usual dose.

Special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy.

Influence on the ability to drive vehicles. There are no data on the negative effect of the drug on the ability to drive vehicles and other mechanisms.

Form of production

Film-coated tablets

Storage conditions

Store at a temperature not exceeding 30 °C.

Shelf

life is 3 years.

Active ingredient

Diosmin

Dosage form

Tablets

Description

For pregnant women as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Hemorrhoids, Trophic ulcers, Varicose veins, Vascular diseases of the eyes