Phlebodia 600 pills 600mg, 60pcs+15pcs

Composition

1 tablet contains: Diosmin in terms of dry matter-600 mg. Auxiliary substances: Talc-10.24 mg, colloidal silicon dioxide-3.5 mg, stearic acid-50.05 mg microcrystalline cellulose up to 910 mg shell: Sepifilm® 002 (hypromellose (E 464) – 9.832 mg, microcrystalline cellulose-7.866 mg, macrogola 8 stearate type 1-1.967 mg). Sepispsrs ® AR 5523 pink (propylene glycol-traces, hypromellose (E 464) – 0.458 mg, titanium dioxide (E 171) -4.026 mg, crimson dye [Ponceau 4R] (E 124) – 0.401 mg, iron oxide black (E 172) – 0.130 mg, iron oxide red (E 172) – 0.020 mg). Opaglos ® 6000 (Carnauba wax (E 903) – 0.075 mg, beeswax (E 901) – 0.075 mg, shellac (E 904) – 0.150 mg, ethanol 95° – traces).

Pharmacological action

Pharmacological group: Angioprotective agent Pharmacological properties: The drug has a phlebotonic effect (reduces the extensibility of veins, increases the tone of veins (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to the paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, has an anti-inflammatory effect. Increases the vasoconstrictive effect of epinephrine, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane. Pharmacokinetics: Rapidly absorbed from the gastrointestinal tract, it is detected in plasma 2 hours after use. The maximum concentration in the blood plasma is reached 5 hours after use. It is evenly distributed and accumulates in all layers of the wall of the vena cava and subcutaneous veins of the lower extremities, to a lesser extent-in the kidneys, liver, lungs and other tissues. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. It is excreted by the kidneys 79%, intestines-11%, with bile-2.4%.

Indications

As part of complex therapy: – to eliminate the symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain; – additional treatment for microcirculation disorders: – symptomatic treatment of acute hemorrhoids.

Use during pregnancy and lactation

So far, no side effects have been reported in clinical practice when using the drug in pregnant women. Use during pregnancy in the second and third trimesters is possible only as prescribed by a doctor in cases where the expected benefit to the mother exceeds the potential risk to the fetus. In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, because there are no data on the penetration of the drug into breast milk.

Contraindications

Hypersensitivity to the components of the drug, breast-feeding, children under 18 years of age, pregnancy (I trimester) (limited experience).

Side effects

In rare cases, hypersensitivity to the components of the drug that requires a break in treatment: from the gastrointestinal tract-dyspeptic disorders (heartburn, nausea, abdominal pain), from the central nervous system – headache. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Clinically significant interaction effects with other drugs have not been described.

How to take, course of use and dosage

Before using the drug, you should consult your doctor. The drug is intended for oral use. With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), I tablet is prescribed per day in the morning on an empty stomach. The duration of therapy is usually 2 months. In case of exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets a day with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug in the usual mode and in the usual dose.

Special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy. Effect on the ability to drive vehicles There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.

Storage conditions

Store at a temperature not exceeding 30 °C. Keep out of reach of children.

Active ingredient

Diosmin

Dosage form

Tablets