Progynova, drags 2mg, 21pcs

Composition

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of 1 tablet contains:

Active ingredient:

estradiol valerate 2 mg;

Auxiliary substances:

lactose monohydrate 46 — 250 mg;

corn starch 26 — 200 mg;

povidone 25000 — 3 mg;

talc — 2.4 mg;

magnesium stearate — 0.15 mg;

sucrose crystal 33 — 540 mg;

povidone 700000 — 0,323 mg;

macrogol 6000 — 3,719 mg;

calcium carbonate precipitated 14 — 572 mg;

talc — 7,104 mg;

glycerol 85% (weight/weight) — 0,205 mg;

titanium dioxide (E 171, P. 1.77891) — 0,411 mg;

Indigo Carmine (E 132, P. 1.73015) — 0,051 mg;

wax montaglycol is 0.075 mg

Pharmacological action

Progynova contains estrogen-estradiol valerate, which in the human body is converted to natural 17b-estradiol. On the background of reception Proginovs do not suppress ovulation, and the production of hormones in the body itself practically does not change.

Estradiol makes up for the lack of estrogens in the female body after menopause and provides effective treatment for psycho-emotional and vegetative climacteric symptoms (such as hot flashes, increased sweating, sleep disorders, increased nervous excitability, irritability, palpitations, cardialgia, dizziness, headache, decreased libido, muscle and joint pain); involution of the skin and mucous membranes, especially those of the genitourinary system (urinary incontinence, dryness and irritation of the vaginal mucosa, soreness during sexual intercourse).

HRT with an adequate dose of estrogen, such as that found in Progin, reduces bone resorption and delays or stops postmenopausal bone loss. Long-term use of hormone replacement therapy (HRT) has been shown to reduce the risk of peripheral bone fractures in postmenopausal women. When HRT is discontinued, the rate of bone loss is comparable to that observed immediately after menopause. It has not been proven that HRT can restore bone mass to pre-menopausal levels.

HRT also has a beneficial effect on the collagen content of the skin, as well as its density, and can also slow down the formation of wrinkles.

HRT reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol, as well as increases triglyceride levels. The addition of progestogen may interfere to some extent with the effects of estradiol on metabolism. In general, the metabolic effects of HRT are considered positive and are thought to be involved in reducing the risk of cardiovascular disease in postmenopausal women.

Women with a non-removed uterus, when using Progynova, are recommended to take an additional progestogen for at least 10 days in each cycle. This reduces the risk of endometrial hyperplasia and the associated risk of adenocarcinoma in women in this group.

Indications

Hormone replacement therapy (HRT) for menopausal disorders, involutive changes in the skin and genitourinary tract, depressive states in the menopausal period, as well as symptoms of estrogen deficiency due to natural menopause or sterilization;

prevention of postmenopausal osteoporosis.

Contraindications

• pregnancy;
• lactation;
• vaginal bleeding of unknown origin;
• confirmed or presumptive breast cancer,
• confirmed or suspected hormone-dependent premalignant disease or hormone-dependent malignant tumors;
• tumors of the liver in the present or in the past (benign or malignant);
• severe liver disease;
• acute arterial thrombosis or thromboembolism (such as myocardial infarction, stroke);
• deep vein thrombosis in the acute stage of thromboembolism currently or in the past;
• there is a high risk of venous and arterial thrombosis;
• severe hypertriglyceridemia;
• congenital deficiency of lactase, sucrase/isomaltase, lactose intolerance, glucose-galactose malabsorption;
• childhood and adolescence to 18 years;
• hypersensitivity to the components of the drug Progynova.

Side effects

In rare cases-headache, nausea, gastric dysfunction, breast engorgement, weight changes, uterine bleeding, chloasma.

How to take, course of use and dosage

Inside, after eating, without chewing and drinking a small amount of liquid,1 tablet daily for 21 days, then a break of 7 days.

If you have menstruation, you should take Progynova on the 5th day of menstrual bleeding.

In any other case, immediate treatment recommended by your doctor is possible.

With the preservation of the uterus, an additional appointment of another hormone, progesterone, is possible. And you need a doctor’s recommendation: whether to take pills constantly (without interruptions) or intermittently.

The time of day of taking Proginov doesn’t matter. However, if the first tablet is taken at a certain time of day, you should adhere to this time and when taking all subsequent tablets.

Form of production

Dragees

Storage conditions

At a temperature not exceeding 30 °C.

Shelf life

5 years

Active ingredient

Estradiol

Conditions of release from pharmacies

By prescription

Dosage form

dragees

Description

For menopausal women, For postmenopausal women, For adults as prescribed by a doctor

Indications

Menopause, Osteoporosis