Prolatan eye drops 0.005% 2.5ml, 3pcs – Sentiss

Composition

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1 ml contains:

Active ingredients:

latanoprost – 0.05 mg,

Auxiliary substances:

benzalkonium chloride-0.2 mg,

sodium chloride-4.1 mg,

disodium hydrophosphate anhydrous-4.74 mg,

sodium dihydrogen phosphate monohydrate-4.6 mg,

d/i water-up to 1 ml

Pharmacological action

Latanoprost, an analog of prostaglandin F2 alpha, is a selective agonist of FP receptors and reduces intraocular pressure (IOP) by increasing the outflow of aqueous humor, mainly through the uveoscleral pathway, as well as through the trabecular network. A decrease in IOP begins approximately 3 to 4 hours after use of the drug, the maximum effect is observed after 8 to 12 hours, and the effect persists for at least 24 hours. It was found that latanoprost does not significantly affect the production of aqueous humor and the blood-ophthalmic barrier. When used in therapeutic doses, latanoprost does not have a significant pharmacological effect on the cardiovascular and respiratory systems.

Indications

Reduction of elevated intraocular pressure (IOP) in adults and children (over the age of 1 year) with open-angle glaucoma or increased ophthalmotonus. Note: In children under 3 years of age with primary congenital glaucoma, first-line treatment remains surgical (trabeculotomy/goniotomy).

Contraindications

Hypersensitivity to latanoprost or other components of the drug. Age up to 1 year (efficacy and safety have not been established). Caution should be exercised in patients with known risk factors for macular edema (cases of macular edema, including cystoid edema, have been reported with latanoprost); inflammatory, neovascular, or congenital glaucoma (due to lack of sufficient experience with the drug); asthma; and a history of herpetic keratitis. The use of Prolatan® should be avoided in patients with active herpetic keratitis and recurrent herpetic keratitis, especially associated with the use of prostaglandin analogues. Prolatan® should be used with caution in patients with risk factors for iritis/uveitis. There are limited data on the use of Prolatan® in patients who are planning cataract surgery. Therefore, Prolatan® should be used with caution in this group of patients.

Side effects

• An increase in the number, length and thickness of ciliary hair, darkening of the skin of the eyelids, changes in the color of the iris, iritis, uveitis, macular edema..
• Blurred vision, eye discomfort, redness of the conjunctiva, pinpoint epithelial keratopathy, edema of the eyelids, crusts on the eyelids, photophobia, conjunctivitis, diplopia..
• Retinal detachment, with diabetic retinopathy of vitreous hemorrhage..
• Respiratory tract infections, angina pectoris, muscle pain, heart rhythm disorders..
• Allergic reactions, rash..
• Bronchial asthma, bronchospasm, shortness of breath.

Interaction

When two prostaglandin analogues are simultaneously instilled into the eyes, a paradoxical increase in IOP has been described, so the simultaneous use of two or more prostaglandins, their analogues or derivatives is not recommended Pharmacologically incompatible with eye drops containing thiomersal-precipitation.

How to take, course of use and dosage

For adult patients and children after 1 year of age, the standard dosage is one drop of Prolatan solution once daily in the affected eye conjunctivally. The optimal effect is achieved if the drug is applied in the evening.

If a dose is missed, the next dose is administered at the usual time.

Overdose

Overdose with Prolatan solution is characterized by redness of the conjunctiva and episclera, nausea, abdominal pain, sweating, hot flashes, fatigue, dizziness.

If necessary, symptomatic therapy should be performed.

Form of production

Eye drops are transparent, colorless.

Active ingredient

Latanoprost

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Glaucoma