Pyrogenal, ampoules 10 µg, 1ml, 10pcs

Composition

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1 ml of the solution contains:

Active ingredient:

bacterial lipopolysaccharide for intramuscular use;

Auxiliary substances:

phosphate buffer solution (pH = 6.7–7.3)

Pharmacological action

Pyrogenal is a broad-spectrum immunomodulator, the main of which are the activation of the reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal has adjuvant, desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body, affects the thermoregulatory centers of the hypothalamus.

The drug, stimulating cells of the phagocytic system, activates phagocytosis, the secretion of oxygen radicals, the synthesis of interleukin – 1 (IL-1, IL-2), tumor necrosis factor (TNF-L), interferon (IFN-L). Acting on fibroblasts, it prevents the synthesis of collagen by fibroblasts, accelerates the process of maturation of fibrocytes.

It stimulates the activity of hyaluronidase: it increases the permeability of tissues, improves the fibrinolytic properties of blood, restores blood circulation, prevents the formation of new and resolves previously formed dense scars and adhesions, prevents vascular obliteration, and stimulates tissue regeneration and epithelialization.

Activates the function of the adrenal cortex: it has an anti-inflammatory effect, increases the concentration of hormones in the blood. It stimulates the kinin system.

Indications

• chronic liver disease;
• stricture of the urethra, ureters, chronic prostatitis, urethritis;
• injury to the Central nervous system and peripheral nervous system
• tuberculosis (torpid form in the phase of resolution);
• uveitis, iridocyclitis, herpes infection of the eye, corneal opacity;
• inflammation of the uterus, infertility;
• adhesive disease of the abdominal cavity;
• burn disease;
• venereal disease;
• psoriasis etc. chronic skin diseases.

For pyrotherapy.

Use during pregnancy and lactation

It is contraindicated during pregnancy and lactation.

Contraindications

• of blood diseases;
• pregnancy.
• acute febrile diseases;
• chronic diseases in the stage of exacerbation and decompensation (with the exception of diseases that are indications for the appointment of the drug);

With caution: diseases of the cardiovascular system, kidneys, diabetes mellitus, reduced seizure threshold, convulsions, febrile seizures.

Side effects

Hyperthermia up to 37.5 °C, accompanied by mild chills and mild malaise. This condition can last from 3 to 8 hours. In this case, the dose that caused such a reaction is repeated in the following days until the reaction to its use stops (usually 1-3 injections), after which the dose is consistently increased.

In rare cases, individuals may experience severe chills, fever up to 39.5 °C, headache, and lower back pain. These reactions usually last from 6 to 8 hours, after which the temperature decreases, and the side effects disappear. In these cases, it is recommended to reduce the dose of the drug.

When using the drug for pyrotherapy, the above reactions are acceptable.

Interaction

The drug is compatible and well combined with all drugs used in the treatment of diseases and conditions indicated in the indications.

Increases the effectiveness of chemotherapeutic drugs as part of complex therapy.

How to take, course of use and dosage

In / m 1 time / day every other day, if necessary, the drug is diluted with 0.9% sodium chloride solution.

The initial single dose is 0.2 mcg, and in subsequent days the dose is gradually increased by 2.5-5 mcg.

The maximum single dose is 100 mcg. Full course – 10-30 injections, if necessary, it is possible to repeat the course-in 2-3 months.

For pyrotherapy – in / m 1 time / day, starting from 5-10 mcg with an increased increase in the dose to 100-150 mcg. Injections are carried out in 1-2 days.

Special instructions

If hyperthermia, chills, and malaise usually occur during intravenous use within 3-8 hours, then the dosage that caused such a reaction is repeated in subsequent days (usually 1-3 days) until the reaction stops, after which the dose is consistently increased.

In the presence of convulsive readiness, the drug is prescribed against the background of anticonvulsant therapy.

Form of production

Solution for intravenous use

Storage conditions

Store in a dry place, protected from light, at a temperature of 2-10 °C

Shelf life

2 years

Active ingredient

Bacterial lipopolysaccharide

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults by doctor’s prescription, Children by doctor’s prescription