Rimantadine Kids syrup 2mg/ml, 100ml

Composition

Active ingredient:

rimantadine hydrochloride – 2.0 mg.

Auxiliary substances:  

sorbitol (liquid sorbitol) – 514.3 mg,

maltitol (liquid maltitol) – 514.3 mg,

carmellose sodium-3.64 mg,

methyl parahydroxybenzoate-1.15 mg,

strawberry flavor-0.63 mg,

purified water-up to 1 ml

Pharmacological action

Rimantadine is an antiviral agent derived from adamantane; it is active against various strains of the influenza A virus. Being a weak base, rimantadine acts by increasing the pH of endosomes that have a membrane of vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material to the cell cytoplasm. Rimantadine also inhibits the release of viral particles from the cell, i. e. interrupts the transcription of the viral genome.

Indications

Prevention and early treatment of influenza A in children over 1 year of age.

Rimantadine prophylaxis can be effective in contact with people who are sick at home, when the infection spreads in closed groups, and when there is a high risk of developing the disease during an influenza epidemic.

Use during pregnancy and lactation

The use of the drug is contraindicated during pregnancy. If necessary, use during lactation should stop breastfeeding.

Recommendations for use

Treatment scheme:

Take orally (after meals), washed down with water, according to the following scheme: children from 1 year to 3 years-on the first day 10 ml (2 teaspoons) of syrup (20 mg) 3 times a day (daily dose – 60 mg); 2 and 3 days – 10 ml 2 times a day (daily dose – 40 mg),4 day – 5 day – 10 ml 1 time a day (daily dose – 20 mg).

Children from 3 to 7 years – on the first day-15 ml (3 teaspoons) of syrup (30 mg) 2 times a day (daily dose-90 mg); 2 and 3 days – 3 teaspoons 2 times a day (daily dose-60 mg),4 days-5 days-3 teaspoons 1 time a day (daily dose-30 mg).

Children from 7 to 10 years of age: 25 ml (5 teaspoons) of syrup (50 mg) 2 times a day for 5 days (daily dose-100 mg).

Children from 11 to 14 years of age: 25 ml (5 teaspoons) of syrup (50 mg) 3 times a day for 5 days (daily dose-150 mg).

Preventive scheme:

For prevention use:

children from 1 year to 3 years – 10 ml (2 teaspoons) syrup (20 mg) 1 time per day,

children from 3 to 7 years – 15 ml (3 teaspoons) syrup (30 mg) 1 times a day,

children over 7 years – 25 ml (5 tablespoons) syrup (50 mg) 1 time per day for 10-15 days.

Attention! The daily dose of rimantadine should not exceed 5 mg per kg of body weight.

Contraindications

• Acute liver diseases;
• acute and chronic kidney diseases;
• thyrotoxicosis;
• pregnancy and lactation;
• children under 1 year of age;
• hypersensitivity to rimantadine and its components
• ;sucrose/isomaltase deficiency;
• glucose-galactose malabsorption;
• fructose intolerance.

With caution

Epilepsy (including in the anamnesis), severe chronic renal failure, liver failure, diabetes mellitus.

Due to the presence of sorbitol in the composition, it should be taken with caution in case of vomiting, abdominal pain and discomfort, diarrhea.

Side effects

From the cardiovascular system:  tachycardia, heart failure,

heart block, palpitation sensation, hypertension, cerebral circulation disorder, loss of consciousness.

Nervous system disorders:  insomnia, dizziness, headache, irritability, fatigue, impaired concentration, movement disorders, drowsiness, depressed mood, euphoria, hyperkinesia, tremor, hallucinations, confusion, convulsions.

From the side of the senses:  tinnitus, change or loss of the sense of smell.

Respiratory system disorders:  shortness of breath, bronchospasm, cough.

From the gastrointestinal tract:  nausea, vomiting, loss of appetite, dryness of the oral mucosa, abdominal pain, diarrhea, dyspepsia.

From the side of the track and subcutaneous tissue:  a rash.

Other services:  fatigue.

Composition

Pharmacodynamic interaction: rimantadine reduces the effectiveness of antiepileptic drugs.

Pharmacokinetic: adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.

Urine acidifying agents (acetazolamide, sodium bicarbonate, etc. ) increase the concentration of rimantadine.

Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine reduces rimantadine clearance by 18%.

The sorbitol contained in the preparation may affect the bioavailability of concomitantly used medications.

Due to the increased risk of dyspeptic symptoms, concomitant use with other medications containing sorbitol is not recommended.

Overdose

In some cases, if the recommended dose is exceeded, the following symptoms are observed: eye watering and eye pain, frequent urination, fever, constipation, sweating, inflammation of the oral mucosa, dry skin.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Special instructions

The use of rimantadine for 2-3 days before and 6-7 hours after the onset of clinical manifestations of influenza type A reduces the severity of symptoms of the disease and the degree of serological response. Some therapeutic effects may also occur if rimantadine is prescribed within 18 hours of the onset of the first flu symptoms.

When used, it is possible to exacerbate chronic concomitant diseases.

In patients with epilepsy, rimantadine increases the risk of developing an epileptic seizure. 15 ml of syrup corresponds to 1 bread unit (XE), which should be taken into account when prescribing the drug to patients with diabetes mellitus.

Viruses that are resistant to the drug may appear.

Sorbitol can cause abdominal discomfort and have a laxative effect. If such effects develop during treatment, the drug should be discontinued and a doctor should be consulted.

Due to the increased risk of dyspeptic symptoms, concomitant use with foods containing significant amounts of sorbitol (prunes, etc. ) is not recommended.

Influence on the ability to drive vehicles and mechanisms

Given the likelihood of side effects from the central nervous system, caution should be exercised when driving vehicles and mechanisms.

Storage conditions

At a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date indicated on the package.

Active ingredient

Rimantadine

Conditions of release from pharmacies

By prescription

Dosage form

syrup