Rinsasip with vitamin C powder for oral solution Orange 5g sachet, 5pcs

Product description

It helps to relieve the main symptoms of colds, acute respiratory viral infections and flu, because it contains a complex of active ingredients.

Composition

1 sachet (5 g) contains

Active ingredients:  

ascorbic acid (vitamin C) – 200 mg,

caffeine-30 mg,

paracetamol-750 mg,

phenyramine maleate 20 mg,

phenylephrine hydrochloride 10 mg,

Auxiliary substances:  

citric acid-200 mg,

sodium saccharinate-40 mg,

sodium citrate-500 mg,

sucrose-3062.5 mg,

dye sunny sunset yellow (E 110) – 7.5 mg,

orange flavor-150 mg.

Clinical Pharmacology

Pharmacodynamics : Combined remedy, has antipyretic, analgesic, alpha-adrenostimulating, vasoconstrictor and antihistamine effects, eliminates the symptoms of “cold”. Paracetamol is a non-narcotic analgesic; it blocks cyclooxygenase (COX), mainly in the central nervous system, affecting the centers of pain and thermoregulation; it has analgesic and antipyretic effects. Phenylephrine is an alpha-adrenomimetic with a moderate vasoconstrictor effect. Reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses. Phenyramine is a blocker of H1-histamine receptors. It has an anti-allergic effect: eliminates itching of the eyes, nose and throat, swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, reduces exudative manifestations. Caffeine has a stimulating effect on the central nervous system, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance, reduces fatigue and drowsiness. Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and the synthesis of steroid hormones; it reduces vascular permeability and increases the body’s resistance to various adverse environmental factors.

Indications

Symptomatic treatment of “colds”, flu, acute respiratory viral infections (fever syndrome, pain syndrome, rhinorrhea).

Use during pregnancy and lactation

Due to the lack of clinical data, the safety of using the drug during pregnancy and lactation has not been established, so the use of the drug in this category of patients is contraindicated.

Contraindications

• Severe coronary artery atherosclerosis, portal hypertension, concomitant use of tricyclic antidepressants, beta-blockers, monoamine oxidase (MAO) inhibitors and discontinuation of their use less than 2 weeks ago;
• sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption;
• Hypersensitivity to individual components of the drug, as well as to sympathomimetic drugs;
• Simultaneous use of medicines containing substances that are part of the drug;
• Pregnancy, lactation, children under 15 years of age, alcoholism.

Side effects

Allergic reactions: skin rash, pruritus, urticaria, angioedema, hypersensitivity reaction, anaphylactic reaction. From the nervous system: headache, dizziness, sleep disturbance, insomnia, drowsiness, increased excitability. From the cardiovascular system: increased blood pressure, tachycardia, palpitation sensation. From the digestive system: nausea, vomiting, epigastric pain, dryness of the oral mucosa, increased activity of liver enzymes, hepatotoxic effect. From the sensory organs: mydriasis, paresis of accommodation, increased intraocular pressure. Hematopoietic disorders: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia. From the urinary system: nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis), difficulty urinating. Other: bronchospasm, dryness of the nasal mucosa. Serious skin reactions: Very rare: – Acute generalized exanthematous pustulosis (OGEP). Acute condition with the development of pustular rashes. It is characterized by fever and diffuse erythema accompanied by burning and itching. There may be swelling of the face, hands and mucous membranes; – Stevens-Johnson syndrome (SSD) (malignant exudative erythema). Severe form of erythema multiforme, in which blisters appear on the mucous membrane of the mouth, throat, eyes, genitals, and other areas of the skin and mucous membranes. – Toxic epidermal necrolysis (TEN, Lyell’s syndrome). The syndrome is a consequence of extensive apoptosis of keratinocytes, which leads to peeling of large areas of the skin at the sites of the dermoepidermal junction. The affected skin has the appearance of scalded with boiling water. If you notice any of the side effects described above, you should stop taking the drug and immediately consult a doctor!

Interaction

Increases the effects of monoamine oxidase (MAO) inhibitors, sedatives, and ethanol. When taken with digoxin or other cardiac glycosides, the risk of arrhythmia and myocardial infarction may increase. Antidepressants, antiparkinsonian drugs, antipsychotics, and phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation. Glucocorticosteroids increase the risk of glaucoma. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects. Metoclopramide and domperidone increase, and colestyramine reduces the rate of absorption of paracetamol. Paracetamol reduces the effectiveness of diuretic and uricosuric drugs. Concomitant use with barbiturates, diphenine, carbamazepine, rifampicin, and other inducers of microsomal liver enzymes increases the risk of hepatotoxic effects of paracetamol. In most patients taking warfarin for a long time, the infrequent use of paracetamol usually has little or no effect on the international normalized ratio (INR). However, with prolonged regular use, paracetamol increases the effect of indirect anticoagulants (warfarin and other coumarin derivatives), which increases the risk of bleeding. A single high dose of caffeine increases the excretion of lithium by the kidneys. Abrupt discontinuation of caffeine can lead to an increase in the concentration of lithium in the blood serum. When taken concomitantly with monoamine oxidase (MAO) inhibitors, furazolidone, phenyramine can lead to a hypertensive crisis, agitation, and hyperpyrexia. When taken with MAO inhibitors, phenylephrine can lead to increased blood pressure. Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs. It also reduces the hypotensive effect of guanethidine, which, in turn, increases the alpha-adrenomimetic activity of phenylephrine. Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, while concomitant use of halothane increases the risk of ventricular arrhythmia.

How to take, course of use and dosage

Inside. Pour the contents of 1 sachet (sachet) into a glass, pour hot water, mix until completely dissolved and drink (if desired, you can add sugar or honey). Taking the drug is recommended 1-2 hours after a meal. Adults and children over 15 years of age: take one sachet 3-4 times a day with intervals between doses of 4-6 hours. The maximum daily dose is 4 sachets. The course of treatment without consulting a doctor is no more than 5 days.

Overdose

In case of overdose, you should immediately consult a doctor. Getting medical attention quickly is critical, even if you don’t notice any signs or symptoms.

• Ascorbic acid:

Symptoms of acute overdose: diarrhea and other gastrointestinal disorders. Symptoms of chronic ascorbic acid intoxication: impaired excretory function of the kidneys, formation of kidney stones, decreased capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies, iron metabolism disorders), erosion of tooth enamel.

• Caffeine:

Symptoms of acute overdose: abdominal pain, nausea, vomiting, fever, chills, headache, agitation, insomnia, irritability, loss of appetite, weakness, tremor, anxiety, altered state of consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia, tachypnea, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, epileptic seizures, convulsions, myoclonia and rhabdomyolysis, supraventricular and ventricular arrhythmias. Symptoms of chronic caffeine intoxication (“caffeinism”): irritability, insomnia, anxiety, emotional lability, chronic abdominal pain.

• Phenyramine:

Symptoms: central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushes of blood to the face, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, hypotension, hypertension, nausea, vomiting, psychomotor agitation, disorientation, hallucinations, psychosis, convulsions, arrhythmias. Rarely, patients with agitation, seizures, or coma develop rhabdomyolysis and renal failure.

• Phenylephrine:

Symptoms: headache, nausea, vomiting, irritability, agitation, insomnia, psychosis, convulsions, palpitations, tachycardia, high blood pressure, reflex bradycardia.

• Paracetamol:

Symptoms that occur after taking more than 7.5-10 g: during the first 24 hours after taking – pallor of the skin, nausea, vomiting, anorexia, abdominal pain, increased prothrombin time, impaired glucose metabolism, hypokalemia, metabolic acidosis (including lactic acidosis). Symptoms of liver dysfunction may appear 12-48 hours after an overdose: increased activity of “liver” transaminases, hepatonecrosis. In severe cases – liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis). The overdose threshold can be lowered in elderly patients and children, in patients taking certain medications (for example, inducers of microsomal liver enzymes), alcohol, or suffering from exhaustion. Treatment: gastric lavage, use of activated charcoal in the first 6 hours after overdose, use of SH-group donors and glutathione – methionine synthesis precursors in 8-9 hours after overdose and acetylcysteine – in 12 hours. The need for additional therapeutic measures (further use of methionine and acetylcysteine) depends on the concentration of paracetamol in the blood, as well as on the time elapsed after taking it. Symptomatic therapy.

Description

Orange: light orange to orange colored powder with white and orange flecks.

Special instructions

During the treatment period, you should refrain from taking alcohol. If the symptoms of the disease worsen or persist for 5 days, or if new symptoms appear, you should consult your doctor. The drug may cause drowsiness. The drug contains sucrose, which should be taken into account in patients suffering from diabetes, as well as people who are on a hypocaloric diet. A single dose of the drug contains from 2915.0 to 3136.0 mg of sucrose, which corresponds to 0.24-0.26 XE. Keep out of reach of children. If the drug is swallowed by a child, seek immediate medical attention. If the medicine has fallen into disrepair or the expiration date has expired, do not throw it into the sewer or on the street! Place the medicine in a plastic bag and put it in the trash can. These measures will help protect the environment!

Form of production

Powder for preparation of an oral solution

Storage conditions

Store in a dry place at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf life

3 years

Active ingredient

Paracetamol, Ascorbic Acid, Caffeine, Phenyramine, Phenylephrine

Dosage form

oral solution