Spasmalin, 5ml ampoules, 5pcs

Composition

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1 ml of the solution contains metamizole sodium 500 mg, pitofenone hydrochloride 2 mg, fenpiverinium bromide 0.02 mg

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Combined antispasmodic.

Metamizole sodium, a pyrazolone derivative, is an analgesic-an antipyretic with a pronounced analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Pitofenone is a myotropic antispasmodic, has a direct effect on the smooth muscles of internal organs and causes its relaxation.

Fenpiverinium bromide – m-holinoblokator, has an additional antispasmodic effect on smooth muscles.

Indications

• pain of various origins
• spasms of internal organs (renal colic, biliary colic)
• postoperative pain. spasms of the brain vessels.

Contraindications

• agranulocytosis
• ischemic heart
• disease glaucoma
• prostate adenoma
• severe hepatic-renal insufficiency
• hypersensitivity to the components of the drug.

Side effects

• a decrease in the number of white blood cells in the blood
• a drop in blood pressure
• impaired renal function
• allergic reactions.

Interaction

Concomitant use of Spasmalin with other non-opioid analgesics may lead to mutual enhancement of the effects.

When used concomitantly, tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

When used concomitantly, barbiturates, phenylbutazone, and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.

When used concomitantly, Spasmalin reduces the concentration of cyclosporine in blood plasma.

When used simultaneously, sedatives and tranquilizers enhance the analgesic effect of Spasmalin.

When used concomitantly with histamine_H1-receptor blockers, butyrophenones, phenothiazines, amantadine and quinidine, it is possible to increase the m-cholinolytic effect of drugs.

When used simultaneously with ethanol, mutual enhancement of the effects is possible.

How to take, course of use and dosage

Parenteral use is usually used in emergency cases (renal or biliary colic) and in cases when oral use is impossible (or absorption from the gastrointestinal tract is impaired).

For adults, the average dose for intravenous use is 2 ml. In / m,2-5 ml of the solution is administered 2-3 times a day; the maximum daily dose is 10 ml. The duration of treatment is not more than 5 days.

In children, the dose of Spasmalin for intravenous or intravenous use is set depending on the age.

Overdose

Symptoms:  vomiting, decreased blood pressure, drowsiness, confusion, nausea, epigastric pain, liver and kidney function disorders, convulsions.

Treatment:  gastric lavage, use of activated charcoal; if necessary, conduct symptomatic therapy.

Special instructions

In patients with bronchial asthma, taking the drug can provoke the development of an attack.

Form of production

Solution for injection

Storage conditions

In a dark place, at a temperature not exceeding 25 °C.

Shelf

life is 3 years.

Active ingredient

Metamizole sodium, Pitofenone, Fenpiverinium bromide

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection