Suprax Solutab, Soluble tablets 400mg, 7pcs

Composition

One tablet contains the Active ingredient:

cefixime trihydrate – 447.0 mg (equivalent to cefixime 400.0 mg )

auxiliary substances:

microcrystalline cellulose, low-substituted hyprolose,

colloidal anhydrous

silicon dioxide,

povidone K-30,

strawberry flavor (FA 15757 and PV 4284),

magnesium stearate,

orange yellow S (E 110)dye

Pharmacological action

It has a bactericidal effect.

The mechanism of action is associated with a violation of the synthesis of the bacterial cell wall.

Cefixime is resistant to beta-lactamases produced by many gram-positive and gram-negative bacteria.

Indications

tonsillitis, pharyngitis, sinusitis, acute otitis media acute bronchitis, exacerbation of chronic bronchitis, pneumonia uncomplicated urinary tract infections uncomplicated gonorrhea

Use during pregnancy and lactation

The use of Cephoral Solutab during pregnancy is possible if the intended benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be temporarily discontinued.

Contraindications

hypersensitivity to cephalosporins or penicillins; hypersensitivity to cefixime or components of the drug. It is not recommended for use in children with chronic renal failure and in children weighing less than 25 kg in this dosage form.

With caution, the drug should be prescribed for renal failure, colitis (in the anamnesis), during pregnancy, as well as elderly patients.

Side effects

From the hematopoietic system: very rarely – transient leukopenia, agranulocytosis, pancytopenia, thrombocytopenia or eosinophilia; in some cases-blood clotting disorders.

Allergic reactions: rarely-urticaria, pruritus of the skin; very rarely-Lyell’s syndrome (in this case, the drug should be discontinued immediately), drug fever, a syndrome resembling serum sickness, hemolytic anemia and interstitial nephritis (with the development of anaphylactic shock, epinephrine (epinephrine), systemic corticosteroids and antihistamines are administered).

From the central nervous system: infrequently-headaches, dizziness, dysphoria.

From the digestive system: often-abdominal pain, digestive disorders, nausea, vomiting and diarrhea; rarely-transient increase in the level of alkaline phosphatase and transaminases; very rarely-pseudomembranous colitis; in some cases-hepatitis and cholestatic jaundice.

From the urinary system: very rarely-a slight increase in the concentration of creatinine in the blood, hematuria.

Interaction

Tubular secretion blockers (including probenecid) slow the excretion of cefixime in the urine, which can lead to symptoms of overdose.

Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.

When cefixime was co-administered with carbamazepine, an increase in the concentration of the latter in plasma was observed; in such cases, therapeutic drug monitoring is advisable.

How to take, course of use and dosage

For adults and children with a body weight of more than 50 kg, the daily dose is 400 mg in 1 or 2 doses. For children with a body weight of 25-50 kg, the drug is prescribed at a dose of 200 mg / day in 1 reception. The tablet can be swallowed with a sufficient amount of water, or diluted in water and drink the resulting suspension immediately after cooking.

The drug can be taken regardless of food intake. The duration of treatment depends on the nature of the course of the disease and the type of infection. After the symptoms of infection and/or fever disappear, it is advisable to continue taking the drug for at least 48-72 hours. The course of treatment for respiratory tract and ENT infections is 7-14 days. For tonsillopharyngitis caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

In uncomplicated gonorrhea, the drug is prescribed at a dose of 400 mg once. For uncomplicated infections of the lower urinary tract in women, the drug is prescribed for 3-7 days, for uncomplicated infections of the upper urinary tract in women – for 14 days. For uncomplicated upper and lower urinary tract infections in men, the duration of treatment is 7-14 days.

Overdose

When taken at a dose exceeding the maximum daily dose, the frequency of the dose-dependent side effects described above may increase.

Treatment: gastric lavage; perform symptomatic and supportive therapy. Hemodialysis and peritoneal dialysis are not effective.

Special instructions

In patients with renal insufficiency, the drug should be administered with caution; with creatinine clearance Due to the possibility of cross-allergic reactions with penicillins, it is recommended to carefully evaluate the patient’s medical history.

If an allergic reaction occurs, the drug should be discontinued immediately. With prolonged use of the drug, it is possible to disrupt the normal intestinal microflora, which can lead to excessive reproduction of Clostridium difficile and the development of pseudomembranous colitis. If mild forms of antibiotic-associated diarrhea occur, it is usually sufficient to stop taking the drug.

In severe cases, corrective treatment is recommended (for example, oral use of vancomycin 250 mg 4 times a day). Dispersible tablets should only be dissolved in water. During treatment, a false positive direct Coombs reaction and a false positive reaction of urine to glucose are possible when using some test systems for rapid diagnosis. Research on the effect of Suprax® Solutab tests on the ability to drive vehicles and work with mechanisms were not performed.

Form of production

Tablets dispersed pale orange color, oblong, with a risk on both sides, with the smell of strawberries.

Storage conditions

Keep out of the reach of children and out of the reach of light, at a temperature not exceeding 25 °C.

Active ingredient

Cefixime

Conditions of release from pharmacies

By prescription

Dosage form

soluble tablets

Description

Children as prescribed by a doctor, Adults as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Urinary Tract Infections, Sore Throat, Otitis Media, Tonsillitis, Pharyngitis, Bronchitis, Infectious diseases, Sinusitis