Indications
Infected wounds in the second phase of the wound process (absence of pus, necrotic tissues) caused by sensitive microorganisms: burns of 2-3 degrees, long-term non-healing trophic ulcers.
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Infected wounds in the second phase of the wound process (absence of pus, necrotic tissues) caused by sensitive microorganisms: burns of 2-3 degrees, long-term non-healing trophic ulcers.
Hypersensitivity to chloramphenicol and other excipients, neonatal period (up to 4 weeks), inhibition of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, hepatic and / or renal failure, skin diseases (fungal lesions, psoriasis, eczema), phase I of the wound process (due to lack of osmotic activity).
Active substance: chloramphenicol [D, L] – 10.0 g;
excipients: castor oil-20.0 g, emulsifier No.1-5.0 g, sorbic acid-0.2 g, sodium carmellose-1.98 g, purified water – up to 100.0 g.
Active ingredient: chloramphenicol [D, L] – 10.0 g;
excipients: castor oil-20.0 g, emulsifier No. 1-5.0 g, sorbic acid-0.2 g, sodium carmellose-1.98 g, purified water-up to 100.0 g
Bacteriostatic broad-spectrum antibiotic, left-and right-rotating isomer of chloramphenicol. Disrupts the process of protein synthesis in a microbial cell (having high lipophilicity, it penetrates the bacterial cell membrane and reversibly binds to the 50S subunit of bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, and sulfonamides. Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization.
Pharmacokinetics
The degree of systemic action after application to the skin is unknown.
Infected wounds in the second phase of the wound process (absence of pus, necrotic tissues) caused by sensitive microorganisms: burns of 2-3 degrees, long-term non-healing trophic ulcers.
There are no data on adverse effects on the fetus and newborn when using the drug during pregnancy or lactation. You should consult your doctor.
Hypersensitivity to chloramphenicol and other excipients, neonatal period (up to 4 weeks), inhibition of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, hepatic and / or renal failure, skin diseases (fungal lesions, psoriasis, eczema), phase I of the wound process (due to lack of osmotic activity).
Allergic reactions – skin rash, angioedema.
Hematopoietic disorders: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.
If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
When used concomitantly with erythromycin, clindamycin, or lincomycin, a mutual weakening of the action is possible due to the fact that chloramphenicol [D, L] can displace these drugs from the bound state or prevent their binding to the 50S subunit of bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.
Externally. After surgical treatment of wounds and burns, liniment is applied directly to the wound surface, after which a sterile gauze dressing is applied or liniment is applied to the dressing material, and then to the wound. Swabs with liniment loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turunds with the drug are inserted into the fistulous passages.
Multiplicity of application – 1 time in 1-3 days, depending on the dynamics of healing.
Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.
No overdose cases have been reported.
uniform liniment of white or white with a yellowish tinge of color with a faint characteristic smell.
In the course of treatment, systematic monitoring of the peripheral blood picture is necessary. When applied to large surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions).
Influence on the ability to drive vehicles and mechanisms
Not detected.
Liniment 10% of 25.0 g in aluminum tubes with bouchons with internal lacquer coating. Each tube together with the instructions for medical use of the drug is placed in a cardboard pack.
0.1 kg; 1.0 kg; 2.0 kg or 5.0 kg of the drug in cans made of polypropylene or high-density polyethylene, complete with lids for hospitals.
At a temperature not exceeding 15 °C. Keep out of reach of children.
life 2 years Do not apply after the expiration date.
Chloramphenicol
ointment
Burns, Skin Infections
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