Teraligen pills 5mg, 100pcs

Composition

One tablet contains:

Active ingredient:

alimemazine tartrate – 5.0 mg;

excipients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, colloidal silicon dioxide (aerosil), croscarmellose sodium, magnesium stearate.

shell composition: Opadray II 85F34655: partially hydrolyzed polyvinyl alcohol, macrogol-3350, talc, titanium dioxide E 171, carmine red dye E 120, aluminum varnish based on sunny sunset yellow dye E 110, aluminum varnish based on indigo carmine E 132.

Pharmacological action

Pharmacotherapy group

Anxiolytic agent. Sedative agent

ATX code

R06AD

Pharmacodynamics :

It is a phenothiazine derivative.

Alimemazine acts as a mild sedative and anti-anxiety agent has a positive effect on obsessive-compulsive disorder and phobia.

It is used for psychosomatic manifestations of vascular traumatic and infectious disorders of the central nervous system that develop as a result of neurovegetative disorders. The sedative effect contributes to the normalization of sleep in patients of this category.

It has antiemetic and antitussive activity.

Sedative and anxiolytic effects are caused by the blockade of adrenoreceptors of the reticular formation of the brain stem. The antiemetic and vegetative-stabilizing effect is due to the blockade of dopamine D2-receptors of the trigger zone of the emetic center.

Due to its antihistamine activity, alimemazine is used for allergic diseases, especially of the respiratory tract and itching of the skin.

Alimemazine is more active in antihistamines and sedatives than diprazine. The antipruritic effect is due to the effect on histamine receptors of the first type.

Pharmacokinetics:

It is rapidly and completely absorbed by any route of use. The effect of alimemazine begins 15-20 minutes after use and lasts 6-8 hours. Binding to plasma proteins is 20-30%. It is metabolized in the liver. Excreted by the kidneys-70-80% in the form of a metabolite (sulfoxide).

Indications

For adults and children over 7 years of age:

As a sedative (sedative), anti-anxiety, and sleep-enhancing agent: organic anxiety disorder (mono or combination therapy); in combination therapy: dementia, schizophrenia (with a predominance of neurosis-like disorders), affective disorders, generalized anxiety disorder, obsessive-compulsive disorder, reaction to severe stress and adaptation disorders, dissociative (conversion) disorders, somatoform disorders in severe anxiety or when standard therapy is ineffective, unspecified disorders of the autonomic nervous system (NS), other disorders of the autonomic nervous system (NS), anorexia nervosa, emotionally unstable personality disorder (impulsive and borderline types), hysterical personality disorder, anxious personality disorder, persistent personality change after experiencing a catastrophe, hyperkinetic behavior disorder, family-restricted behavior disorder, unsocialized behavior disorder, anxiety agitation and other symptoms and signs related to the emotional state, other neurotic disorders (neurasthenia, unspecified neurotic disorders), insomnia of non-organic etiology, emotional disorders whose onset is specific for childhood (phobic, social, unspecified emotional, other emotional disorders in childhood. As an anti-allergic agent: pruritus, regardless of the place and etiology, asthma, pollinosis, whooping cough, unspecified allergy.

For children from 3 years of age:

As an anti-allergic agent: itching regardless of the location and etiology (itching when photocontact dermatitis and solar urticaria, dermatitis, eczema, hives, bites or Galiani non-poisonous insects or arthropods, chickenpox, measles, Hodgkin’s Disease, diabetes, shingles, itching, anus, vulva, unspecified anogenital) as monotherapy or in combination therapy. As a sedative (sedative) agent: during medical preparation for surgery (for the purpose of sedation before surgery).

Contraindications

Hypersensitivity, lactose intolerance, lactase deficiency, glucose-galactose malabsorption, angle-closure glaucoma, prostatic hyperplasia, severe hepatic and / or renal failure, Parkinsonism, myasthenia gravis, Reye’s syndrome, concomitant use of MAO inhibitors, pregnancy and lactation, children under 3 years of age when used as an anti-allergic agent and for sedation before surgery, up to 7 years for other indications.

Side effects

Side effects are extremely rare and mild. From the nervous system: drowsiness, lethargy, rapid fatigue (occur mainly in the first days of taking the drug and rarely require discontinuation of the drug), paradoxical reaction (anxiety, agitation, nightmares, irritability), confusion, extrapyramidal disorders. From the side of the senses: blurred visual perception, noise or ringing in the ears. From the cardiovascular system: dizziness, low blood pressure, tachycardia. Allergic reactions, muscle relaxation. A list of all side effects is provided in the instructions for medical use.

Interaction

Increases the effects of narcotic analgesics, sleeping pills, anxiolytic and antipsychotic drugs, as well as drugs for general anesthesia, m-holinoblokatorov and antihypertensive. When used: with antiepileptic drugs and barbiturates, the threshold of convulsive activity decreases, with beta-blockers, a pronounced decrease in blood pressure, arrhythmia is possible, with MAO inhibitors or phenothiazine derivatives, the risk of arterial hypotension and extrapyramidal disorders increases. List of all interactions with others. The drug is presented in the instructions for medical use.

How to take, course of use and dosage

Inside, without chewing.

For adults:

Course treatment should start with 2.5-5 mg in the evening with a gradual increase in the daily dose to the desired effect. The daily dose can be divided into 3-4 doses. The duration of treatment can be from 2 to 6 months or more and is determined by the doctor. To achieve: vegetative-stabilizing effect-15-60 mg / day, anxiolytic effect-20-80 mg/day, sedative and / or hypnotic effect-5-10 mg / day once (for 20-30 minutes). before bedtime), for the symptomatic treatment of allergic reactions-10-40 mg / day. The maximum dose for adults is 500 mg / day, for persons over 60 years of age-200 mg/day.

Children from 7 years of age (depending on age and body weight): to achieve an anxiolytic effect-20-40 mg / day. The course of treatment should begin with 2.5-5 mg with a gradual increase in the daily dose to the desired effect. The daily dose can be divided into 3-4 doses. To achieve a sedative and/or hypnotic effect – 2.5-5 mg once (20-30 minutes before bedtime), to achieve a sedative effect in case of behavioral disorders in psychotic states, it is possible to increase the daily dose to 60 mg / day. For symptomatic treatment of allergic reactions – 5-20 mg / day. The duration of the course of treatment can be from 2 to 6 months or more and is determined by the doctor.

Children from 3 years of age:

For the symptomatic treatment of allergic reactions,2.5-5 mg 3-4 times / day. The duration of the course of treatment can be from 2 to 6 months or more and is determined by the doctor. For the purpose of sedation before surgery, children from 3 to 7 years are prescribed at the rate of 2 mg / kg 1-2 hours before surgery. The maximum daily dose is 2 mg / kg.

Special instructions

Do not drink alcohol during the treatment period. When taking the drug, you should not engage in activities that require increased concentration of attention and speed of psychomotor reactions.

Shelf life

3 years

Active ingredient

Alimemazine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets