Teturam, pills 150mg, 30pcs

Composition

Active ingredient:

teturam 150 mg;

Auxiliary substances:

potato starch,

stearic acid,

aerosil.

Pharmacological action

Teturam inhibits acetaldehyde dehydrogenase, which is involved in the metabolism of ethanol; increases the concentration of acetaldehyde, which is a metabolite of ethanol and causes a number of unpleasant sensations after its use (“hot flashes” of blood to the skin of the face, nausea, vomiting, feeling unwell, tachycardia, lowering blood pressure).

As a result, a conditioned reflex reaction of disgust to the taste and smell of ethanol is developed.

The duration of action of oral tablets is 48 hours. Application in the form of implants creates a constant concentration of the drug in the body. Disulfiram-ethanol reactions may occur within 5-9 months after implantation.

In the case of ethanol intake, lipids are mobilized, blood vessels dilate and blood flow at the implantation site increases, as a result of which the supply of disulfiram to the blood increases.

Indications

Treatment and prevention of relapses of chronic alcoholism; as a detoxification agent for chronic nickel poisoning.

Contraindications

Absolute values:

• Severe diseases of the cardiovascular system.
• Organ of hearing (neuritis of the auditory nerve).
• Organ of vision (glaucoma, optic neuritis).
• Bronchial asthma.
• Emphysema of the lungs.
• Tuberculosis of the lungs.
• Severe liver failure.
• Diseases of hematopoietic organs.
• Diabetes mellitus.
• Thyrotoxicosis.
• Epilepsy.
• Convulsive syndrome of any genesis.
• Mental illnesses.
• Exacerbation of peptic ulcer disease.
• Kidney diseases.
• Malignant tumors.
• Polyneuritis of any etiology.
• Pregnancy.
• Increased individual sensitivity to the drug.

Relative values:

• Cardiovascular diseases in the compensation stage.
• Older age (over 60 years).
• Peptic ulcer of the stomach and duodenum 12 in remission.
• Residual effects after NMC.
• Previously transferred teturam (antabus) psychoses.

Side effects

During treatment with Teturam, a bitter taste in the oral cavity, headache, dizziness, memory disorder, insomnia, and anxiety may appear.

The most common side effects of Teturam are allergic reactions – urticaria, skin rash, angioedema, bronchospasm, dermatitis.

When Teturam tablets are implanted, rejection may occur, which manifests itself in the form of collapse, arrhythmia, brain edema, suppuration, and heart attack.

Interaction

Contraindicated combinations

Alcohol: an intolerance reaction (hot flashes, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.

Unwanted combinations

Isoniazid: behavioral and coordination disorders.

Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion.

Phenytoin. : a significant and rapid increase in the level of phenytoin in plasma with toxic symptoms (suppression of its metabolism).

If the combination cannot be avoided, clinical monitoring and monitoring of the drug’s plasma concentrations should be performed before and after treatment with teturam.

Combinations that require caution

Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (reduced breakdown of warfarin in the liver). More frequent monitoring of warfarin concentrations and dose adjustment of anticoagulants are recommended within 8 days after teturam withdrawal.

Theophylline: Teturam inhibits theophylline metabolism. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the concentration of the drug in plasma.

Benzodiazepines: Teturam may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). The dosage of benzodiazepine should be adjusted according to the clinical manifestations.

Tricyclic antidepressants: it is possible to increase the reaction of alcohol intolerance (especially if patients take alcoholic beverages while taking teturam).

How to take, course of use and dosage

Treatment is prescribed after a thorough examination of the patient and warnings about the consequences and complications. The drug is taken orally no more than 500 mg 1 time a day according to an individual scheme.

After 7-10 days, a teturamalcohol test is performed (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the alcohol dose is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml).

The test is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with correction of alcohol and/or drug doses as necessary. In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.

Overdose

Symptoms: the combination of teturam-ethanol can cause depression of consciousness up to coma, cardiovascular collapse, and neurological complications.

Treatment: symptomatic.

Special instructions

Patients should be warned about the danger of an alcohol intolerance reaction.

Teturam should be taken with caution in patients with renal insufficiency or hypothyroidism, especially at the risk of possible combination with alcohol.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf

life is 5 years.

Active ingredient

Disulfiram

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Alcoholism