Tiloron-SZ pills 125mg, 6pcs

Composition

One film-coated tablet contains: Active ingredient: tilorone dihydrochloride – 125 mg;excipients (core): microcrystalline cellulose – 105.0 mg; potato starch-46.0 mg; hypromellose (hydroxypropyl-methylcellulose)-4.0 mg, hyprolose (hydroxypropylcellulose) -17.0 mg; magnesium stearate-3.0 mg; excipients (shell): Opa – dry II 85F220184-9.0 mg (macrogol (polyethylene glycol) 3350 – 2.7890 mg; talc – 1.1806 mg; titanium dioxide E 171 – 1.1874 mg; aluminum varnish based on the dye sunny sunset yellow E 110 – 1.3315 mg; iron oxide yellow dye E 172 – 1.1800 mg, indigo carmine dye E 132 – 1.3315 mg).

Pharmacological action

Low molecular weight synthetic interferon inducer that stimulates the formation of all types of interferons (alpha, beta, gamma and lambda) in the body. The main producers of interferon in response to the introduction of tiloron are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral use, the maximum production of interferon is determined in the gut – liver – blood sequence after 4-24 hours. Tiloron has an immunomodulatory and antiviral effect. After a single oral use of tilorone at a dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda was determined after 24 hours, interferon alpha-after 48 hours. Induction of interferon lambda in the lung tissue increases the antiviral protection of the respiratory tract in influenza and other respiratory viral infections. In human leukocytes, it induces the synthesis of interferon. It stimulates bone marrow stem cells, increases antibody formation depending on the dose, reduces the degree of immunosuppression, and restores the ratio of T-suppressors and T-helpers. It is effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed. Pharmacokineticsafter oral use, it is rapidly absorbed from the gastrointestinal tract. Bioavailability – 60%. About 80% of the drug binds to plasma proteins. The drug is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). The elimination half-life (T 1/2) is 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.

Indications

For adults: – treatment of influenza and other acute respiratory infections; – treatment of herpes infection. Prevention of influenza and other acute respiratory infections in adults.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy. If it is necessary to prescribe the drug during lactation, stop breastfeeding.

Contraindications

-Hypersensitivity to tilorone or any other component of the drug;- pregnancy and breast-feeding period; – children’s age (up to 18 years).

Side effects

Possible allergic reactions, dyspeptic phenomena, short-term chills. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is compatible with antibiotics and drugs for the traditional treatment of viral and bacterial diseases. There was no clinically significant interaction of tilorone with antibiotics and traditional treatments for viral and bacterial diseases.

How to take, course of use and dosage

Tiloron is taken orally, after meals. For the treatment of influenza and other acute respiratory infections-125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. For the course-750 mg (6 tablets). For the prevention of influenza and other acute respiratory viral infections-125 mg 1 time a week for 6 weeks. For the course -750 mg (6 tablets). For the treatment of herpetic infection – the first two days of 125 mg, then after 48 hours of 125 mg. The course dose is 1.25-2.5 g (10-20 tablets). In the treatment of influenza and other acute respiratory viral infections, if symptoms persist for more than 4 days, you should consult a doctor.

Overdose

Cases of overdose of the drug are unknown.

Special instructions

The effect of a medicinal product for medical use on the ability to drive vehicles, mechanisms and mechanisms does not adversely affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Tiloron

Dosage form

Tablets