Tobrex, eye drops 0.3%, 5ml

Composition

Active ingredient: tobramycin 3.00 mg; Excipients: benzalkonium chloride, solution equivalent to benzalkonium chloride 0.10 mg; boric acid 12.40 mg; sodium sulfate anhydrous 1.52 mg; sodium chloride 2.78 mg; tyloxapol 1.00 mg;sulfuric acid and / or sodium hydroxide to adjust the pH;purified water to 1 ml

Pharmacological action

Tobrex eye drops contain tobramycin, a broad-spectrum antibiotic from the aminoglycoside group. The bactericidal effect of the drug extends to Streptococcus and Staphylococcus bacteria, Klebsiella, Escherichia coli, and diphtheria bacteria.

At low concentrations, it acts bacteriostatically (blocks the 30S subunit of ribosomes and disrupts protein synthesis), and at higher concentrations, it acts bactericidal (disrupts the function of cytoplasmic membranes, causing microbial cell death).

Highly active against Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis (coagulase-negative and coagulase-positive), as well as penicillin-resistant strains); Streptococcus spp. (including α-β-hemolytic species, some non-hemolytic species, Streptococcus pneumoniae); Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis (indole-negative) and indole-positive species Proteus spp., Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus (Herellea vaginacola), some species of Neisseria spp. (including Neisseria gonorrhoeae).

Pharmacokinetics

When applied topically, systemic absorption is low.

Indications

Infections of the eye and its appendages: – blepharitis;- conjunctivitis;- keratoconjunctivitis;- blepharoconjunctivitis;- keratitis;- iridocyclitis. Prevention of postoperative infections.

Use during pregnancy and lactation

There is no sufficient experience with the use of the drug during pregnancy and lactation (breastfeeding). It is possible to use Tobrex eye drops in pregnant women and nursing mothers if the expected therapeutic effect exceeds the potential risk of side effects.

Use in children

There is no sufficient experience in using Tobrex eye drops in children. It is possible to use the drug in children if the expected therapeutic effect exceeds the potential risk of side effects.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Local users. Allergic reaction, accompanied by itching and swelling of the eyelids, conjunctival hyperemia, lacrimation. There may be a burning sensation and a foreign body sensation in the eye.

Interaction

If tobramycin is co-administered topically with systemic aminoglycoside antibiotics, systemic side effects may increase.

How to take, course of use and dosage

Locally. Eye drops: With a mild infectious process,1-2 drops in the conjunctival sac every 4 hours. In acute severe infectious process,2 drops in the conjunctival sac every 60 minutes, with a decrease in the frequency of instillation of the drug as the inflammatory phenomena decrease.

Overdose

Symptoms: pinpoint keratitis, erythema, increased lacrimation, itching and swelling of the eyelid. Treatment is symptomatic.

Special instructions

Contact lenses should not be worn during treatment with the drug.

Long-term use of Tobrex eye drops, as with other antibiotics, can lead to increased growth of non-susceptible microorganisms (including fungi). It is recommended to do seeding before and after the end of treatment, if the clinical result is unsatisfactory.

Influence on the ability to drive motor vehicles and manage mechanisms

It is not recommended to drive a car or work with complex machinery, machines, or any other complex equipment that requires clear vision for patients who have temporarily impaired visual clarity after instillation of Tobrex.

Form of production

Tobrex. Eye drops.

Storage conditions

At a temperature of 8-30 °C

Shelf life

3 years

Active ingredient

Tobramycin

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

Nursing mothers as prescribed by a doctor, Adults as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Eye Infections, Blepharitis, Inflammatory Eye Diseases, Conjunctivitis, Iridocyclitis