Trombless, gel 1 ths.me/g, 30g

Composition

>of 1 g of gel contains: Active ingredient: Sodium heparin-1000 IU (0.00833 g with the activity of sodium heparin 120 IU / mg); Excipients: Ethanol (ethyl alcohol) — 0.24 g, methyl parahydroxybenzoate (nipagin, methylparaben) — 0,0012 g Parahydroxybenzoate (nipazol, propylparaben),0.0003 g, diethanolamine (2,2-iminodiethanol) — up to 0,014 g to obtain a gel with a pH from 7.5 to 8.7, Karbomer (carbopol) — up to 0.015 g, Water (purified water) — up to 1 g.

Pharmacological action

Pharmacodynamically the anticoagulant, anti-inflammatory, antiproliferative, anti-edematous and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. Trombless ® improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and thrombi, ultimately restoring the patency of the veins, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect. Pharmacokinetic Sansignificant amounts of heparin are absorbed from the skin surface into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after application. Elimination of heparin mainly occurs through the kidneys, with a half-life of 12 hours.

Indications

• migratory phlebitis in CVI;
• thrombophlebitis of the superficial veins of the extremities and varicose ulcers;
• subcutaneous hematomas
• ; post-injection phlebitis and phlebitis after surgical interventions on the veins;
• injuries and bruises of tendons and muscle tissue;
• local soft tissue edema.

Application during pregnancy and lactation

, the percutaneous route of use is considered the safest-the gel acts locally and ensures the concentration of the drug substance in the lesion.

There is practically no overall resorptive effect, and the dose can be reduced if necessary.

These points allow you to use the drug during pregnancy with varicose veins.

Contraindications

Hypersensitivity to the components of the drug. Ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; increased tendency to bleeding, thrombocytopenia.

Side effects

With prolonged use of Trombless, local reactions in the form of skin hyperemia, allergic reactions are possible.

Interaction

Concomitant use of the gel with indirect anticoagulants may cause prolongation of prothrombin time. The gel is not prescribed topically simultaneously with nonsteroidal anti-inflammatory drugs, tetracyclines, antihistamines.

How to take, course of use and dosage

Trombless gel is applied topically. Gel with a length of 3-10 cm (depending on the area of the affected area) is lightly rubbed into the skin 1-3 times a day.

Apply daily-4-7 days. The course of treatment is determined by the doctor.

In the treatment of hemorrhoids, the instructions for use of Trombless prescribe applying the drug to a cotton swab, which is applied to the affected area.

Overdose

Overdose is unlikely, as systemic absorption is minimal.

Special instructions

The drug should not be used for bleeding, as well as on open wounds, on mucous membranes and with purulent processes.

Form of production

Gel for external use 1000 IU/g. 10,20,30,40,50 g in aluminum tubes or polyethylene laminate tubes. Each tube together with the instructions for medical use of the drug is placed in a pack of cardboard.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Sodium Heparin

Dosage form

gel for external use

Description

For pregnant women, Nursing mothers as prescribed by a doctor, For adults

Indications

Swelling after injuries and operations, Hematomas, Tendon inflammation, Thrombophlebitis, Varicose veins, Dislocations and sprains, Bruises