Trypsin, 10mg vials, 10pcs

Composition

1 bottle contains:  

Active ingredient:

trypsin (bovine pancreas) 10 mg

Pharmacological action

Trypsin is a proteolytic enzyme preparation derived from the pancreas of cattle.

Trypsin has pronounced anti-inflammatory and decongestant properties, is able to break down dead tissue areas, fibrinous formations, viscous secretions and exudates.

In relation to healthy tissues, the enzyme is inactive and safe due to the presence of trypsin inhibitors (specific and non-specific). It does not affect the hemostatic system.

Indications

Bronchiectatic disease, lung abscesses, exudative pleurisy, postoperative atelectasis, pleural empyema; treatment of purulent wounds and burns;chronic purulent otitis, purulent sinusitis, sinusitis;acute thrombophlebitis, acute and chronic odontogenic osteomyelitis, inflammatory-dystrophic forms of periodontal disease, acute iridae and iridocyclitis, hemorrhages in the eye chamber and edema near-ocular tissues after injuries and operations, obstruction of the lacrimal ducts.

Use during pregnancy and lactation

This is only possible if the expected benefit to the woman exceeds the possible risk to both the woman and the child.

Contraindications

Hypersensitivity, heart failure, emphysema of the lungs with respiratory failure, decompensated form of pulmonary tuberculosis, dystrophy and cirrhosis of the liver, infectious hepatitis, kidney damage, pancreatitis, hemorrhagic diathesis.

Side effects

• Allergic reactions.
• Increased body temperature, tachycardia.
• Pain and hyperemia at the injection site during intramuscular use.
• When inhaled trypsin may cause irritation of the mucous membranes of the upper respiratory tract and hoarseness of the voice.

Interaction

Only when inhaled, you can add bronchodilators and antibiotics to the solution.

How to take, course of use and dosage

Intramuscularly. Adults-5-10 mg 1-2 times a day; children-2.5 mg 1 time a day. For injection, immediately before use,5 mg of trypsin crystal is diluted in 1-2 ml of 0.9% NaCl solution or 0.5-2% procaine solution. The course of treatment is 6-15 injections. Trypsin electrophoresis is also used: for 1 procedure,10 mg of trypsin (dissolved in 15-20 ml of distilled water) is introduced from the negative pole.

By inhalation:  5-10 mg in 2-3 ml of 0.9% NaCl solution through an inhaler or through a bronchoscope. After inhalation, rinse your mouth with warm water and rinse your nose.

Eye drops:  conjunctivally,0.2-0.25% solution, which is prepared immediately before use.

Intrapleural:  1 time a day,10-20 mg, dissolved in 20-50 ml of 0.9% NaCl solution.

Intrapleural:  50-150 mg in 5-30 ml of phosphate buffer solution, after use, frequent changes in body position are desirable; on the 2nd day after instillation, as a rule, a liquefied exudate is released.

Locally:  A three-layer fabric made of dialdehyde cellulose soaked in trypsin solution is applied to the wound (after its treatment) and fixed with a bandage, left on the wound for no more than 24 hours. Before use, the cloth is moistened with distilled water or furatsilin solution. The time of complete cleaning of the wound from necrotic tissues and pus is 24-72 hours. If necessary, apply again.

Special instructions

Do not inject the drug into the foci of inflammation and into bleeding cavities.

Do not administer the drug intravenously.

Do not apply trypsin to ulcerated surfaces of malignant tumors in order to avoid the spread of the malignant process.

Form of production

Lyophilizate for solution preparation for injection and topical application

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 10 °C

Shelf life

3 years

Active ingredient

Trypsin

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Purulent wounds, Trophic ulcers, Skin infections, Swelling after injuries and operations, Sinusitis, Respiratory tract infections, Burns, Thrombophlebitis, Otitis