Indications
– For dissolving uric acid stones.
– To prevent (prevent relapses) the formation of calcium-containing and uric acid stones, as well as mixed stones-calcium oxalate/uric acid or calcium oxalate/calcium phosphate.
$113.00
Active ingredient: | |
---|---|
Dosage form: |
– For dissolving uric acid stones.
– To prevent (prevent relapses) the formation of calcium-containing and uric acid stones, as well as mixed stones-calcium oxalate/uric acid or calcium oxalate/calcium phosphate.
-Hypersensitivity to the components of the drug.
– Acute or chronic renal failure.
– Metabolic alkalosis.
– Hereditary episodic adynamia.
– Chronic urinary tract infections caused by bacteria that break down urea (risk of formation of struvite stones).
– A low-salt diet.
– Acute dehydration.
– Patients who combine a urine pH above 7 with poorly controlled diabetes mellitus or with adrenal insufficiency.
– Use in children under 12 years of age is not recommended, as there is insufficient clinical experience regarding this age group.
Uralit-U is used with caution in patients with severe hepatic impairment.
In a measuring spoon (2.5 g) of granules for the preparation of a solution for oral use contains:
active substance:
potassium-sodium-hydrogen citrate 2,4277 g
. excipients:
hydrated water of the active substance 67.3 mg,
dye sunny sunset (E 110) 0.2 mg,
lemon oil 4.8 mg.
In a measuring spoon (2.5 g) of granules for the preparation of a solution for oral use contains:
Active ingredient:
potassium-sodium-hydrogen citrate 2,4277 g
. excipients:
hydrated water of the Active ingredient 67.3 mg,
dye sunny sunset (E 110) 0.2 mg,
lemon oil 4.8 mg.
– For dissolving uric acid stones.
– To prevent (prevent relapses) the formation of calcium-containing and uric acid stones, as well as mixed stones-calcium oxalate/uric acid or calcium oxalate/calcium phosphate.
-Hypersensitivity to the components of the drug. – Acute or chronic renal failure. – Metabolic alkalosis. – Hereditary episodic adynamia. – Chronic urinary tract infections caused by bacteria that break down urea (risk of formation of struvite stones). – A low-salt diet. – Acute dehydration. – Patients who combine a urine pH above 7 with poorly controlled diabetes mellitus or with adrenal insufficiency. – Use in children under 12 years of age is not recommended, as there is insufficient clinical experience regarding this age group.
Uralit-U is used with caution in patients with severe hepatic impairment.
Dyspepsia, phosphate nephrourolithiasis.
Any increase in extracellular potassium concentration will weaken the effect of cardiac glycosides, while any decrease will increase the arrhythmogenic effect of cardiac glycosides.
Aldosterone antagonists, potassium-sparing diuretics, ACE inhibitors, nonsteroidal anti-inflammatory drugs, and non-narcotic analgesics reduce renal potassium excretion.
It should be remembered that 1.0 g of the drug contains 0.172 g or 4.4 mmol of potassium. When following a low-sodium diet, it should be taken into account that 1.0 g of Uralita-Y contains 0.1 g or 4.4 mmol of sodium, which is equivalent to 0.26 g of sodium chloride.
Preparations containing citrates, when taken simultaneously with preparations containing aluminum, may increase the absorption of aluminum. If you need to take such drugs, the interval between taking each of them should be at least 2 hours.
The granules should be dissolved in a glass of water and drunk.
To dissolve and prevent the recurrence of uric acid stones: as a rule, take 4 scoops (= 10 g of granules, which is equivalent to 88 mmol of alkali) per day, divided into three doses, after meals. 1 measuring spoon is taken in the morning,1 measuring spoon-in the afternoon, and 2 measuring spoons in the evening, while the pH of fresh urine should be in the range of 6.2 – 6.8. If the pH value is below the recommended range, you should increase the daily dose by half a measuring spoon (11 mmol of alkali), adding it to the evening intake of the drug. If the pH value is higher than the recommended range, the daily dose should be reduced by half a scoop (11 mmol of alkali) by reducing the evening dose. The dose will be considered correctly selected when the pH of fresh urine before taking Uralit-U is within the recommended range.
To prevent the formation of uric acid stones, it is recommended to regularly check the pH of urine.
To prevent the formation of calcium-containing kidney stones: the daily dose is 2-3 scoops (= 5-7.5 g of granules, which is equivalent to 44-66 mmol of alkali) once in the evening. If the pH of the urine is too low, take 3-4.5 scoops (= 7.5-11.25 g of granules, which is equivalent to 66-99 mmol of alkali) in 2-3 doses during the day after meals. You should strive to maintain a urine pH of 7.0, but the pH should not fall below 6.2 or rise above 7.4. It is necessary to regularly monitor the concentration of citrates and / or the pH of urine and adjust the individual dose accordingly (see above).
Urine pH measurement: immediately before each dose of the drug, take an indicator paper strip, which is in the package, and, holding it with a clip (also attached), moisten it with fresh urine. Then compare the color of the wet strip with the color chart and mark the pH value that is printed under the corresponding color. This pH value and the number of accepted measuring spoons with granules are recorded in the control calendar. The patient should take a control calendar with them every time they visit the doctor.
Symptoms: with normal renal function, there is no possibility of undesirable effects on metabolic parameters even after taking doses that exceed the recommended ones, since the elimination of excess amounts of alkali by the kidneys is a natural regulatory mechanism that provides an acid-base state.
Treatment: accidental overdose can be eliminated at any time by reducing the dose; if necessary, consult a doctor, as appropriate measures are usually used to treat metabolic alkalosis.
In all cases, the use of the drug should be part of the general concept of treatment and prevention (diet, increased fluid intake, etc. ). Before starting therapy, it is necessary to conduct examinations aimed at identifying all cases of concomitant diseases that contribute to the formation of kidney stones, in order to exclude them.
This also applies to cases of specific therapy (parathyroid adenoma, malignant tumors that generate the formation of uric acid stones, etc. ). Before the first intake, it is necessary to determine the concentration of electrolytes in the serum and check kidney function. In addition, if renal tubular acidosis (PKA) is suspected, the acid-base status should be checked.
Uralit-U contains the dye sunny sunset (E 110), which in rare cases can cause allergic reactions, including bronchial asthma in sensitized individuals. Allergic reactions are more common in people with hypersensitivity to acetylsalicylic acid.
Treatment with cytostatics: during treatment with cytostatics, it is advisable to alkalize the urine in order to prevent an increase in the concentration of uric acid, which is consistent with measures to prevent the formation of uric acid stones. In addition, there is evidence of a protective effect of the alkaline pH of urine, which reduces the aggressiveness of cytostatic metabolites, such as isophosphamide derivatives (cyclophosphamide, isophosphamide) and increases the solubility of cytostatics (for example, methotrexate) and their metabolites. The pH of urine should be maintained at a level not lower than 7.0. In cutaneous porphyria, there is a deficiency of uroporphyrinogen decarboxylase, under the action of which uroporphyrinogen is metabolized to coproporphyrinogen.
The purpose of metabolic alkalinization is to prevent the reverse diffusion of coproporphyrin through the renal tubules, which in turn contributes to an increase in coproporphyrin clearance. It is believed that as a result of increased coproporphyrinogen excretion, the synthesis of coproporphyrinogen from uroporphyrinogen increases and, as a result, the amount of circulating uroporphyrin decreases. The pH value of urine should correspond to 7.2 – 7.5.
Influence on the ability to drive motor vehicles and manage mechanisms: absent.
Granulate for the preparation of an oral solution
Store at a temperature not exceeding 25°C.
life is 5 years.
Potassium sodium hydrocitrate
By prescription
oral solution
Reviews
There are no reviews yet