Skinoren, cream 20%, 30g

Composition

Active ingredient:  

azelaic acid – 200 mg.

Auxiliary substances:  

benzoic acid,

macrogol glyceryl stearate,

a mixture of glyceryl stearate,

cetostearyl alcohol,

cetyl palmitate and coconut oil fatty acid glycerides,

cetostearyl ethyl capronate,

propylene glycol,

glycerol 85%,

purified water.

Pharmacological action

Skinoren is a drug for the treatment of acne.

Azelaic acid normalizes disturbed keratinization processes in the follicles of the sebaceous glands, reduces the content of free fatty acids in skin lipids and reduces its fat content.

It has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis.

The anti-inflammatory effect is also due to a decrease in neutrophil metabolism and a decrease in the production of free radical oxygen forms.

Azelaic acid has a dose-and time-dependent inhibitory effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics:

Suction

After application to the skin, azelaic acid is practically not absorbed into the systemic circulation (no more than 3.6% with a single application of 5 g of gel or cream).

Elimination

Part of the absorbed azelaic acid is excreted unchanged by the kidneys, and part in the form of dicarboxylic acids (C7, C5) formed from azelaic acid as a result of beta-oxidation.

Indications

Acne vulgaris; hyperpigmentation, including melasma, chloasma.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Local reactions:

rarely ( mainly at the beginning of therapy) – skin irritation, erythema, burning sensation, itching, peeling, which go away on their own during further treatment; after applying the cream to the skin of the face, a burning and tingling sensation may occur, which passes within 15 minutes.

How to take, course of use and dosage

The dosage regimen and duration of therapy are set individually.

The cream is applied evenly in a thin layer 2 times a day on previously cleansed (with mild cleansers and water) areas of the face and, if necessary, the neck and upper chest affected by acne.

The drug should be used regularly throughout the entire course of treatment, the duration of which depends on the severity of the disease. The minimum duration of treatment for melasma is 3 months.

Special instructions

Avoid getting the drug in the eyes, as well as on the mucous membranes of the nose, lips and mouth.

In cases of severe skin irritation in the first weeks of treatment, Skinoren can be used 1 time / day; short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug should be resumed at the recommended dose.

Skinoren can be used in combination with other acne treatments. At the same time, it is possible to adjust the dosage regimen of drugs used simultaneously.

Product form

Cream.

Storage conditions

At a temperature not exceeding 25 °C.

Shelf

life is 3 years.

Active ingredient

Azelaic Acid

Dosage form

cream

Indications

Hyperpigmentation, Acne