Sodium chloride solution for infusion 0.9% container, 250ml 10pcs

Composition

Auxiliary substances:

d/i water-up to 1 l

Pharmacological action

It has a detoxifying and rehydrating effect. It makes up for sodium deficiency in various pathological conditions of the body and temporarily increases the volume of fluid circulating in the vessels. The pharmacodynamic properties of the solution are due to the presence of sodium and chloride ions. A number of ions, including sodium ions, penetrate the cell membrane by various transport mechanisms, among which the sodium-potassium pump (Na-K – ATPase) is of great importance. Sodium plays an important role in the transmission of signals in neurons, the electrophysiological processes of the heart, as well as in the metabolic processes in the kidneys. Sodium is mainly excreted by the kidneys, but a large amount of sodium is reabsorbed (renal reabsorption). A small amount of sodium is excreted in the feces and during sweating.

Indications

• Isotonic extracellular dehydration;
• hyponatremia;
• dilution and dissolution of parenterally administered drugs (as a base solution).

Contraindications

• Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration;
• circulatory disorders that threaten brain and lung edema;
• brain edema, pulmonary edema, acute left ventricular failure, concomitant use of corticosteroids in large doses.

When adding other drugs to the solution, it is necessary to take into account contraindications to these drugs.

With caution:  decompensated chronic heart failure, arterial hypertension, peripheral edema, preeclampsia, chronic renal failure (oligo -, anuria), aldosteronism and other conditions associated with sodium retention in the body.

Side effects

Acidosis, hyperhydration, hypokalemia. If used correctly, undesirable effects are unlikely. When using 0.9% sodium chloride solution as a base solution (solvent) for other drugs, the probability of side effects is determined by the properties of these drugs. In this case, if adverse reactions occur, the solution should be suspended, the patient’s condition should be assessed, appropriate measures should be taken, and the remaining solution should be retained for analysis, if necessary. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Not described.

When mixing with other medicinal products, it is necessary to visually monitor compatibility.

To do this, the resulting solution should be monitored for changes in its color and / or precipitation, the appearance of crystals, and insoluble complexes.

It is also necessary to take into account the instructions for use of the added drugs.

How to take, course of use and dosage

Intravenously (usually by drip). The required dose can be calculated in mEq or mmol of sodium, mass of sodium ions, or mass of sodium chloride (1 g of NaCl = 394 mg,17.1 mEq or 17.1 mmol of Na and Cl). The dose is determined depending on the patient’s condition, body fluid loss, Na+ and Cl-, age, and body weight of the patient. Serum concentrations of electrolytes in plasma and urine should be carefully monitored. The dose of sodium chloride solution for adults is from 500 ml to 3 liters per day. The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg of body weight (depending on age and total body weight). The rate of use depends on the patient’s condition. The recommended dose when used for dilution and dissolution of parenterally administered drugs (as a base solution-solvent) is in the range from 50 ml to 250 ml per dose of the administered drug. In this case, the dose and rate of use of the solution are determined by the recommendations for the use of the administered drug.

Overdose

Symptoms: nausea, vomiting, diarrhea, spastic abdominal pain, thirst, decreased salivation and lacrimation, sweating, fever, tachycardia, increased blood pressure, renal failure, peripheral edema, pulmonary edema, respiratory arrest, headache, dizziness, restlessness, irritability, weakness, muscle cramps and rigidity, generalized seizures, coma and death. Excessive use of the solution may cause hypernatremia. Excessive intake of chloride in the body can lead to hyperchloric acidosis. When used as a base solution for dilution and dissolution of other drugs, symptoms and complaints with excessive use are most often associated with the properties of the administered drugs. In case of unintentional excessive use of the solution, treatment should be discontinued and the patient’s condition evaluated. Treatment: symptomatic.

Special instructions

During any infusion, it is necessary to monitor the patient’s condition, clinical and biological parameters, and it is especially important to evaluate plasma electrolytes. In the body of children, due to immaturity of kidney function, sodium excretion may slow down. Therefore, in such patients, repeated infusions should be performed only after determining the concentration of sodium in the plasma.

Use only a clear solution, without visible inclusions, if the package is not damaged. Enter immediately after connecting to the infusion system. Do not connect plastic containers in series. This can lead to an air embolism due to the suction of air remaining in the first container, which can occur before the solution is delivered from the next container. The solution should be administered using sterile equipment in compliance with the rules of asepsis and antiseptics. To avoid air entering the infusion system, the infusion system should be filled with the solution, releasing the remaining air from the container completely. You can add other drugs to the solution before or during the infusion by injecting them into a specially designated area of the container.

As with all parenteral solutions, the compatibility of the added substances with the solution must be determined before dissolution.

Drugs known to be incompatible with 0.9% sodium chloride solution should not be used. To determine the compatibility of the added medicinal substances with a 0.9% sodium chloride solution, the doctor should check for possible changes in color and / or the appearance of sediments, insoluble complexes or crystals.

Before adding, it is necessary to determine whether the added substance is soluble and stable in water at a pH level similar to that of 0.9% sodium chloride solution.

When adding the drug, it is necessary to determine the isotonicity of the resulting solution before infusion. Before adding drugs to the solution, they must be thoroughly mixed in compliance with the rules of asepsis. The prepared solution should be introduced immediately after cooking, do not store!

The addition of other drugs or a violation of the technique of use can cause fever due to the possible ingestion of pyrogens. In case of development of undesirable reactions, it is necessary to immediately stop the use of the solution. Before applying the solution, do not remove the container from the outer protective polypropylene/polyamide bag in which it is placed, as it supports the sterility of the drug. Instructions for using Viaflo containers

1. Opening the package.

a. Remove the Viaflo container from the outer bag immediately before use.

b. When squeezing the container tightly, it is necessary to check it for its integrity. If mechanical damage is detected, the container should be disposed of, as sterility may be compromised.

B. Check the solution for transparency and absence of inclusions. The container should be disposed of if the transparency is broken or there are inclusions.

2. Preparation for use.

To prepare and administer the solution, use sterile materials. a. Hang the container by the loop to the tripod. Remove the plastic fuse from the outlet port located at the bottom of the container:

• grasp the small wing on the mouth of the outlet port with one hand,
• grasp the large wing on the lid with the other hand and twist
• it until the lid opens.

B. When setting up an infusion system, you should follow the rules of antiseptics.

city of Install the infusion system according to the instructions for connecting, filling the system, and injecting the solution, which are contained in the instructions for the system.

3. Adding other drugs to the solution.

Warning: the added drugs may not be compatible with the solution.

To add before entering:

a. Disinfect the drug injection area on the container (drug injection port).

b. Using a syringe with a size 19-22 needle (1.10-0.70 mm), make a puncture in this area and inject the drug.

B. Mix the product thoroughly with the solution. For high-density drugs, such as potassium chloride, carefully inject the drug through the syringe, holding the container so that the drug port is on top (upside down), and then mix.

Warning: Do not store containers that contain drugs.

To add the drug during use:

a. Turn the system clamp that controls the solution supply to the “Closed” position.

b. Disinfect the drug injection area on the container (drug injection port).

B. Using a syringe with a size 19-22 needle (1.10-0.70 mm), make a puncture in this area and inject the drug.

city ofRemove the container from the tripod and / or turn it upside down.

D. Remove air from both ports.

E. Mix the product thoroughly with the solution.

g. Return the container to its working position, move the system clamp to the “Open” position, and continue inserting.

Containers should be disposed of after a single use. Each unused dose should be disposed of.

Do not re-connect partially used containers (regardless of the amount of solution remaining in it).

Influence on the ability to drive motor vehicles and manage mechanisms

Not described.

Storage conditions

At a temperature not exceeding 25°C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Sodium Chloride

Conditions of release from pharmacies

By prescription

Dosage form

solution for infusions

Purpose

For adults as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Restoration of water-salt balance, Preparation of medicinal solutions