Stopdiar, 220mg/5ml suspension, 90ml

Composition

5 ml of suspension contains:

Active ingredients:

nifuroxazide 220 mg.

Auxiliary substances:

carbomer-11 mg,

sucrose-1100 mg,

sodium hydroxide-2.2 mg,

citric acid monohydrate-0.83 mg,

simethicone 30% emulsion (anti-foam emulsion) – 11 mg,

methyl parahydroxybenzoate-5.5 mg,

banana flavor-4.57 mg,

water-up to 5 ml

Pharmacological action

Pharmacodynamics

Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran; it is active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents): gram-positive (family of Staphylococcus) and Gram-negative (family of Enterobacteriaceae: Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, Proteus, Yersinia), as well as Vibrio cholerae. He is active against bacteria of the genus Pseudomonas and the genus Proteus (species Proteus inconstans), as well as strains of subgroup A of the species Providentia alcalifaciens. It is assumed that the drug inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. In medium therapeutic doses, it has bacteriostatic activity, and in higher ones, it acts bactericidal. The effect is evident from the first hours of treatment.

In therapeutic doses, it practically does not disturb the balance of the symbiotic bacterial flora of the intestine; it does not cause the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, for generalized infections, it can be prescribed in complex therapy with systemic drugs. In case of intestinal infections of viral origin, it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral use, it is practically not absorbed from the digestive tract, creating a high concentration of the Active ingredient in the intestine. Due to these pharmacokinetic features, the drug has an exclusively enteric antiseptic effect, does not have systemic antibacterial activity, does not cause general toxic effects; it is excreted from the body with feces. The drug does not affect the clinical and biochemical parameters of the blood test.

Indications

Acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophylus influenzae), as well as some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp. ).

Use during pregnancy and lactation

There are no data on the adverse effects on the fetus when using the drug during pregnancy.

If necessary, with caution, the drug can be prescribed to pregnant women and women who are breastfeeding.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug;fructose intolerance, glucose-galactose malabsorption syndrome or sucrose and isomaltase insufficiency; pregnancy; newborn period up to 1 month, prematurity.

Side effects

Allergic reactions (skin rash, urticaria, angioedema, anaphylactic shock). If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Concomitant use with drugs that cause the development of disulfiram-like reactions, drugs that inhibit the function of the central nervous system is not recommended. If you are taking other medications (including over-the-counter medications), please consult your doctor before using Stopdiar.

How to take, course of use and dosage

Before taking the drug, shake the bottle several times so that the suspension becomes homogeneous. The drug can be washed down with water. Children aged 1 to 6 months:  110 mg (1 small measuring spoon of suspension) 2-3 times a day (the interval between doses is 8-12 hours). Children aged 6 months to 3 years:  110 mg (1 small measuring spoon of suspension) 3 times a day (interval between doses of 8 hours). Children aged 3 to 6 years:  220 mg (1 large measuring spoon of suspension) 3 times a day (interval between doses of 8 hours). Children aged 6-18 years:  220 mg (1 large measuring spoon of suspension) 3-4 times a day (the interval between doses is 6-8 hours). Adults:  220 mg (1 large measuring spoon of suspension) 4 times a day (interval between doses of 6 hours). Stopdiar should be used for 5-7 days, but not more than 7 days. If there is no improvement during the first 3 days of taking it, then you should consult a doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Overdose

Overdose symptoms are not described.

In case of overdose, gastric lavage and symptomatic treatment are recommended.

Special instructions

When treating diarrhea simultaneously with nifuroxazide therapy, rehydration therapy should be performed. Treatment of diarrhea in children under 3 years of age is recommended under the supervision of a doctor. In case of bacterial diarrhea with signs of systemic damage (deterioration of the general condition, fever, symptoms of intoxication or infection), you should consult a doctor to decide on the use of antibacterial drugs of systemic action. If you experience symptoms of hypersensitivity (shortness of breath, rash, itching), you should stop taking the drug. Alcohol consumption is prohibited during therapy. Stopdiar contains sucrose. Patients with rare hereditary problems of fructose tolerance, glucose-galactose malabsorption, or sucrose and isomaltase insufficiency should not take this medicine. Due to the content of methyl parahydroxybenzoate, Stopdiar may cause allergic reactions (possibly delayed). One small measuring spoon of suspension contains 0.09 XE (bread units), one large measuring spoon of suspension contains 0.18 XE. The daily dose of suspension for children aged 1 month to 3 years contains 0.27 XE. The daily dose of suspension for children aged 3 to 6 years contains 0.54 XE. The maximum daily dose of suspension for children aged 6 to 18 years contains 0.72 XE. The daily dose of suspension for adults contains 0.72 XE.

Form of production

Suspension for oral use.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Nifuroxazide

Dosage form

Oral suspension