Sulfacyl sodium Renewal eye drops 20% 2ml, 2pcs

Composition

Per 1 ml of Active ingredient: Sulfacetamide-200 mgm Auxiliary substances: sodium thiosulfate-1 mg hydrochloric acid (1 M hydrochloric acid solution) – up to pH 8.5 water for injection-up to 1 ml

Pharmacological action

Pharmacodynamics Antimicrobial bacteriostatic agent, sulfonamide. The mechanism of action is due to competitive antagonism with paraaminobenzoic acid and inhibition of dihydropteroate synthetase, violation of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii. Pharmacokinetics: When applied topically, the maximum concentration (Cmax) of sulfonamides in the cornea (about 3 mg/ml), anterior chamber moisture (about 0.5 mg/ml), and iris (about 0.1 mg/ml) is reached within the first 30 minutes after application. A certain amount (less than 0.5 mg/ml) is retained in the tissues of the eyeball for 3-4 hours. If the corneal epithelium is damaged, the penetration of sulfonamides increases.

Indications

As part of complex therapy. Conjunctivitis and blepharitis in children and adults, purulent corneal ulcer, prevention and treatment of blennorrhea in newborns, gonorrheal and chlamydial eye diseases in adults.

Use during pregnancy and lactation

There is no sufficient experience in using the drug during pregnancy and lactation. It is possible to use sulfacetamide for the treatment of pregnant and lactating mothers as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of possible side effects.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Burning, lacrimation, pain, itching in the eyes, temporary blurred vision after instillation, allergic reactions.

Interaction

Combined use with procaine and tetracaine reduces the bacteriostatic effect. Incompatibility with silver salts.

How to take, course of use and dosage

Locally. For the treatment of conjunctivitis in children and adults, instill 1-2 drops into the conjunctival sac every hour, and 5-6 times a day in the next 3-4 days. For the treatment of blepharitis in children and adults, the frequency of instillation in the first days is up to 6-8 times and decreases to 3-4 times a day as the condition improves, the duration of treatment is 3-5 days. For the treatment of purulent corneal ulcers as part of complex therapy in the form of instillations 5-6 times a day, for 5-7 days. For the prevention of blennorrhea in newborns,2 drops in each conjunctival sac immediately after birth and 2 drops – 2 hours later during the day, for the treatment of blennorrhea-2 drops in each conjunctival sac every 1-2 hours on the first day, then every 3 hours, the duration of treatment is two weeks. In the treatment of gonorrheal and chlamydial eye diseases in adults, as part of complex therapy,1-2 drops 5-6 times a day, for 4-6 weeks. If the dynamics are positive against the background of the treatment, the number of instillations of drops is reduced in each subsequent week.

Overdose

There are no data on overdose of the drug.

Special instructions

Patients who are hypersensitive to furosemide, thiazide diuretics, sulfonylurea, or carbonic anhydrase inhibitors may be hypersensitive to sulfacetamide. After opening, use within 14 days.

Ability to influence the speed of reactions when driving vehicles or working with other mechanisms

If the patient’s visual clarity is temporarily reduced after using the drug, it is not recommended to drive a car or engage in activities that require increased attention and reaction until it is restored.

Storage conditions

In a dark place at a temperature of 2 to 15 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Sulfacetamide

Dosage form

eye drops

Indications

Blepharitis, Conjunctivitis