Sumamed, 250mg teva capsules 6pcs

Composition

1 capsule contains azithromycin dihydrate 250 mg

Pharmacological action

An antibiotic of the macrolide group-azalide. It has a wide spectrum of antimicrobial action. Binds to the 50S subunit of the ribosome, inhibits protein biosynthesis of microorganisms. In high concentrations, it has a bactericidal effect.

Azithromycin is active against gram-positive aerobic bacteria:  Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, streptococci of groups C, F and G, Staphylococcus aureus, Staphylococcus epidermidis; some gram-positive anaerobic bacteria:  Clostridium perfringens.

Azithromycin is active against gram-negative aerobic bacteria:  Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Neisseria gonorrhoeae, Neisseria meningitidis, Helicobacter pylori, Gardnerella vaginalis, Campylobacter jejuni.

Azithromycin is also active against intracellular and other microorganisms: Mycobacterium avium complex, Legionella pneumophila, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Ureaplasma urealyticum, Listeria monocitogenes, Borrelia burgdorferi, Treponema pallidum.

Gram-positive bacteria resistant to erythromycin are resistant to the drug.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

– infections of the lower respiratory tract (bacterial bronchitis, interstitial and alveolar pneumonia, exacerbation of chronic bronchitis); infections of the upper respiratory tract and ear (bacterial pharyngitis, tonsillitis, sinusitis, otitis media); – infections of the skin and soft tissues (chronic erythema migrans, the initial stage, Lyme disease, erysipelas, impetigo, secondary dermatoses); infection, sexually transmitted infections (urethritis, cervicitis); – diseases of the stomach and duodenum, associated with Helicobacter pylori.

Use during pregnancy and lactation

During pregnancy, the drug should only be administered if the expected benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to introduce Sumamed to women during lactation, it is necessary to decide whether to stop breastfeeding.

Contraindications

-hypersensitivity to macrolide antibiotics; – severe liver and kidney function disorders;

With caution: during pregnancy and lactation, with impaired liver and kidney function, patients with disorders or predisposition to arrhythmias and prolongation of the QT interval.

Interaction

Antacids (containing aluminum, magnesium), ethanol and food intake significantly reduce the absorption of azithromycin (capsules and suspension), so the drug should be taken at least 1 hour before or 2 hours after taking these drugs and eating. Azithromycin, unlike other macrolide antibiotics, does not bind to cytochrome P450 isoenzymes. To date, no interactions with theophylline, terfenadine, carbamazepine, triazolam, or digoxin have been observed.

Macrolides when taken concomitantly with cycloserine, indirect anticoagulants, methylprednisolone, felodipine and drugs undergoing microsomal oxidation (cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral hypoglycemic agents), slow down the elimination, increase the concentration and toxicity of these drugs, while when used in combination with cycloserine, indirect anticoagulants, methylprednisolone, felodipine and drugs undergoing microsomal oxidation (cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral hypoglycemic agents). No such interaction of azalides has been observed to date.

If co-use with warfarin is necessary, careful monitoring of prothrombin time is recommended.

When macrolides are taken simultaneously with ergotamine and dihydroergotamine, their toxic effect may manifest (vascular spasm, dysesthesia).

Lincosamines reduce, and tetracycline and chloramphenicol increase the effectiveness of azithromycin.

Pharmacologically, azithromycin is incompatible with heparin.

How to take, course of use and dosage

The drug is prescribed orally 1 time a day. Capsules should be taken at least 1 hour before or 2 hours after a meal. Children 6 months and older are recommended to use the drug in the form of an oral suspension or 125 mg tablets

For infections of the upper and lower respiratory tract, skin and soft tissues (with the exception of chronic migrating erythema), adults are prescribed the drug at a dose of 500 mg 1 time/day for 3 days, the course dose is 1.5 g.

Children are prescribed at the rate of 10 mg / kg of body weight 1 time / day for 3 days, the course dose is 30 mg/kg.

For chronic erythema migrans:

For adults, the drug is prescribed 1 time/day for 5 days: 1 day – 1 g (2 tablets of 500 mg), then from 2 to 5 days – 500 mg, a course dose of 3 g.

Children are prescribed on day 1 at a dose of 20 mg / kg of body weight and then from 2 to 5 days – daily at a dose of 10 mg/kg of body weight, a course dose of 60 mg/kg.

Overdose

Symptoms: nausea, vomiting, diarrhea, temporary hearing loss.

Treatment: symptomatic.

Special instructions

If you miss taking one dose of the drug, the missed dose should be taken as early as possible, and the subsequent ones should be taken at intervals of 24 hours.

The patient should be warned about the need to inform the doctor about the occurrence of any side effect.

Form of production

Capsules

Storage conditions

Keep out of reach of children at temperatures between 15° and 25°C.

Shelf

life is 3 years.

Active ingredient

Azithromycin

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

Children as prescribed by a doctor, Children over 12 years of age, Pregnant women as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Sinusitis, Bronchitis, Pharyngitis, Respiratory Tract Infections, Sinusitis, Tonsillitis, Otitis Media, Sore Throat, Pneumonia, Skin Infections, Urethritis