Suprastin,, 20mg/ml 1ml ampoules 5pcs

Composition

1 ampoule contains chloropyramine hydrochloride 20 mg.

Auxiliary substances:

d/i water-up to 1 ml

Pharmacological action

An anti-allergic drug. Histamine H1-receptor blocker.

Chloropyramine hydrochloride, a chlorinated analog of tripelenamine (pyribenzamine), is a classic antihistamine belonging to the group of ethylenediamine antihistamines.

It has an antihistamine and m-holinoblokiruyushchy effect, has an antiemetic effect, moderate antispasmodic and peripheral holinoblokiruyushchy activity.

The therapeutic effect of chlorpyramine develops within 15-30 minutes after ingestion, reaches a maximum within the first hour after ingestion and lasts at least 3-6 hours.

Indications

— hives;

serum sickness;

seasonal and year-round allergic rhinitis;

— conjunctivitis;

contact dermatitis;

— itching;

— acute and chronic eczema;

atopic dermatitis;

food and drug Allergy;

allergic reactions to insect stings;

— angioedema (Quincke’s edema) – for solution;

— angioedema (Quincke’s edema) in an aid – for tablets.

Use during pregnancy and lactation

There have been no adequate and well-controlled studies on the use of antihistamines during pregnancy. Therefore, the use of the drug in pregnant women (especially in the first trimester and in the last month of pregnancy) is possible only if the potential benefit to the mother exceeds the possible risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be suspended.

Contraindications

— acute attack of bronchial asthma;

— pregnancy;

— lactation (breastfeeding);

— children’s age up to 3 years (for tablets);

— lactase deficiency, nepalesisch lactose malabsorption syndrome of glucose-galactose (for tablets, because 1 tab. contains 116 mg of lactose monohydrate);

— neonates (term and premature);

— hypersensitivity to the components of the drug.

The drug should be used with caution in patients with angle-closure glaucoma, in patients with urinary retention and prostatic hyperplasia, with impaired liver and/or kidney function, cardiovascular diseases, and in elderly patients.

Side effects

Side effects occur, as a rule, extremely rarely, are temporary and pass after discontinuation of the drug.

From the hematopoietic system:  very rarely – leukopenia, agranulocytosis, hemolytic anemia and other changes in the cellular composition of the blood.

From the central nervous system:  drowsiness, fatigue, dizziness, nervous excitement, tremor, headache, euphoria, convulsions, encephalopathy.

From the side of the visual organ:  blurred vision, glaucoma, increased intraocular pressure.

From the cardiovascular system:  decreased blood pressure, tachycardia, arrhythmia (these side effects were not always directly related to the drug).

From the digestive system:  abdominal discomfort, dry mouth, nausea, vomiting, diarrhea, constipation, loss or increased appetite, epigastric pain.

From the urinary system:  difficulty urinating, urinary retention.

Musculoskeletal disorders:  muscle weakness.

Other services:  photosensitivity, allergic reactions.

If any of the above effects occur, the patient should stop taking the drug and immediately consult a doctor.

Interaction

The drug enhances the effect of barbiturates, M-holinoblokatorov, opioid analgesics.

MAO inhibitors can enhance and prolong the anticholinergic effect of chloropyramine.

In combination with ototoxic drugs Suprastin® may mask signs of ototoxicity.

Antihistamines can distort the results of skin allergy tests, so a few days before the planned test, the use of drugs in this group should be discontinued.

How to take, course of use and dosage

Intravenous use is used only in acute severe cases under the supervision of a doctor.

For adults, the recommended daily dose is 1-2 ml (1-2 ampoules) intravenously.

The following initial doses are recommended for children: :

from 1 to 12 months-0.25 ml (1/4 ampoule) in / m

from 1 year to 6 years-0.5 ml (1/2 ampoule) in / m

from 6 to 14 years-0.5-1 ml (1/2-1 ampoule) in/m.

The dose may be increased cautiously depending on the patient’s response and the observed side effects. However, the dose should never exceed 2 mg / kg of body weight.

In severe cases of allergy, treatment should begin with a careful slow intravenous injection, and then continue with intravenous injections or oral use of the drug.

Special patient groups

Elderly, emaciated patients:  use of Suprastin® it requires special caution, because in these patients, antihistamines are more likely to cause side effects (dizziness, drowsiness).

Patients with impaired liver function:  it may be necessary to reduce the dose due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function:  it may be necessary to change the dosage regimen and reduce the dose due to the fact that the active component is mainly excreted by the kidneys.

Overdose

Symptoms:  hallucinations, restlessness, ataxia, impaired coordination of movements, athetosis, convulsions; in young children-agitation, anxiety, dry mouth, fixed dilated pupils, facial redness, sinus tachycardia, urinary retention, fever, coma; in adults – fever and facial redness are observed intermittently, after a period of excitement, convulsions and post-convulsive depression, coma follow.

Treatment:  in the period up to 12 hours after taking the drug – gastric lavage (it should be borne in mind that the anticholinergic effect of the drug prevents gastric emptying), use of activated charcoal, monitoring of blood pressure and respiration parameters, carrying out symptomatic therapy, if necessary – resuscitation measures. The specific antidote is unknown.

Special instructions

In combination with ototoxic drugs Suprastin® may mask early signs of ototoxicity.

Diseases of the liver and kidneys may require a change (reduction) in the dose of the drug, and therefore the patient should inform the doctor about the presence of liver or kidney disease.

Taking the drug at night may increase the symptoms of reflux esophagitis.

Suprastin® It may increase the effect of ethanol on the central nervous system, and therefore the use of alcoholic beverages should be avoided while taking Suprastin®.

Long-term use of antihistamines can lead to disorders of the hematopoietic system (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during prolonged use there is an unexplained increase in body temperature, laryngitis, pallor of the skin, jaundice, formation of ulcers in the mouth, the appearance of hematomas, unusual and prolonged bleeding, it is necessary to conduct a clinical blood test with determination of the number of shaped elements. If the test results indicate a change in the blood formula, the drug is discontinued.

Influence on the ability to drive motor vehicles and manage mechanisms

The drug, especially in the initial period of treatment, can cause drowsiness, fatigue and dizziness. Therefore, during the initial period, the duration of which is determined individually, it is prohibited to drive vehicles or perform work associated with an increased risk of accidents. After that, the doctor must determine the degree of restriction on driving vehicles and working with mechanisms for each patient individually.

Form of production

Solution for injection.

Storage conditions

Store at room temperature (no higher than 25°C).

Active ingredient

Chloropyramine

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

Children as prescribed by a doctor, Children older than 1 month, Adults as prescribed by a doctor

Indications

Insect Bites, Dermatitis, Urticaria, Allergies, Neurodermatitis, Eczema, Allergic Conjunctivitis, Allergic Rhinitis, Hay Fever