Suprax granules 100mg, 5ml, 30.3-35.0g (60ml)

Composition

of 5 ml of the finished suspension: – cefixime 100 mg

Auxiliary substances:

sodium benzoate,

sucrose,

yellow resin,

strawberry flavor.

Pharmacological action

Pharmaceutical group: antibiotic-cephalosporin. Pharmacology: Suprax is a semi-synthetic cephalosporin broad-spectrum antibiotic of the third generation for oral use. It acts bactericidal.

The mechanism of action is due to inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to beta-lactamases produced by most gram-positive and gram-negative bacteria. In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae. In vitro cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, Staphylococcus spp. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp. are resistant to the drug.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

— pharyngitis—

– tonsillitis

— – sinusitis;

– acute and chronic bronchitis

— – otitis

media; – uncomplicated urinary tract infections

— – uncomplicated gonorrhea.

Use during pregnancy and lactation

Use during pregnancy is only possible if the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Contraindications

Hypersensitivity to cephalosporins and penicillins.

With caution: elderly;

chronic renal failure;

pseudomembranous colitis (in the anamnesis);

children (up to 6 months).

Side effects

Allergic reactions: pruritus, urticaria, hyperemia of the skin, eosinophilia, fever, erythema multiforme, toxic epidermal necrolysis, anaphylactic shock.

From the digestive system: dry mouth, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, dysbiosis, liver dysfunction (increased activity of hepatic transaminases, alkaline phosphatase, hyperbilirubinemia, jaundice), gastrointestinal candidiasis; rarely – stomatitis, glossitis, pseudomembranous enterocolitis.

Hematopoietic disorders: leukopenia, neutropenia, thrombocytopenia, hemolytic anemia. From the urinary system: interstitial nephritis. Nervous system disorders: dizziness, headache.

Interaction

Tubular secretion blockers (allopurinol, diuretics) delay the elimination of cefixime by the kidneys, which can lead to an increase in the concentration of the drug in the blood plasma.

Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow the absorption of cefixime.

How to take, course of use and dosage

Suprax is taken orally.

For adults and children over 12 years of age weighing more than 50 kg, the average daily dose is 400 mg (1 time a day or 200 mg 2 times a day). The average duration of treatment is 7-10 days. For uncomplicated gonorrhea-400 mg once a day. Children under 12 years of age are prescribed as a suspension at a dose of 8 mg / kg once or in 2 doses (4 mg / kg every 12 hours). For children aged from 6 months to 1 year, the daily dose of suspension is 2.5-4 ml, at the age of 2-4 years-5 ml, at the age of 5-11 years-6-10 ml.

For diseases caused by Streptococcus pyogenes, the course of treatment is at least 10 days. In case of impaired renal function, the dose is set depending on the serum creatinine clearance: with a creatinine clearance of 21-60 ml/min or in patients undergoing hemodialysis, the daily dose should be reduced by 25%.

If the creatinine clearance is less than or equal to 20 ml/min or in patients undergoing peritoneal dialysis, the daily dose should be reduced by 2 times.

Method of preparation of the suspension: turn the bottle upside down and shake the powder. Add 40 ml of boiled water cooled to room temperature in 2 steps and shake after each addition until a homogeneous suspension is formed. After that, it is necessary to allow the suspension to settle for 5 minutes to ensure complete dissolution of the powder. The finished suspension should be shaken before use.

Overdose

Symptoms: increased risk of adverse reactions.

Treatment: gastric lavage; symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. It is not excreted in significant amounts by hemo-or peritoneal dialysis.

Special instructions

Patients who have had a history of allergic reactions to penicillins may be hypersensitive to cephalosporin antibiotics.

With prolonged use of the drug, it is possible to disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile, cause severe diarrhea and pseudomembranous colitis. During treatment, a positive direct Coombs reaction and a false positive urine glucose reaction are possible.

Storage conditions

At a temperature of 15-25 °C

Shelf life

3 years

Active ingredient

Cefixime

Conditions of release from pharmacies

By prescription

Dosage form

suspension for oral use

Description

Children as prescribed by a doctor

Indications

Sinusitis, Sore Throat, Otitis Media, Bronchitis, Pharyngitis, Infectious diseases, Urinary tract infections, Tonsillitis