Composition
1 tablet contains
Active ingredient: Â
Betahistine dihydrochloride 24.0 mg;
Auxiliary substances: Â
Microcrystalline cellulose — 64.25 mg,
Povidone (collidone 25) — 27.0 mg
Potato starch — 60.0 mg,
Citric acid — 6.0 mg,
Colloidal silicon dioxide (aerosil), — 9.0 mg,
Talc — /8.4 mg,
Magnesium stearate- / 1.35 mg
Pharmacological action
Betahistine improves the microcirculation of the labyrinth, is used for pathology of the vestibular apparatus.
The drug acts mainly on histamine H1 and H3 receptors of the inner ear and vestibular nuclei of the central nervous system.
By direct agonistic action on histamine H1-receptors of the inner ear vessels, as well as indirectly through action on histamine H3-receptors, it improves microcirculation and
capillary permeability, normalizes endolymph pressure in the labyrinth and cochlea. At the same time, betahistine increases blood flow in the basilar artery.
It has a pronounced central effect, being an inhibitor of histamine H3-receptors of the vestibular nerve nuclei. Normalizes conduction in neurons of the vestibular nuclei at the level of the brain stem.
The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in tinnitus, and an improvement in hearing in the case of its decrease.
Indications
- Treatment and prevention of vestibular vertigo of various origins;
- Syndromes that include dizziness and headache, tinnitus, progressive hearing loss, nausea, and vomiting.
- Meniere’s disease or syndrome.
Contraindications
- hypersensitivity to any of the components of the drug:
- under 18 years of age (due to lack of data);
- pregnancy and lactation (due to lack of data). With caution
, peptic ulcer of the stomach or duodenum (including in the anamnesis), pheochromocytoma, bronchial asthma. These patients should be monitored regularly during treatment.
Side effects
Gastrointestinal disorders. the appearance of hypersensitivity reactions from the skin (rash, itching, urticaria), angioedema.
Interaction
Interactions or incompatibilities with other medicinal products are unknown.
How to take, course of use and dosage
Inside, while eating. Tablets 24 mg: 1 tablet 2 times a day. Improvement is usually noted already at the beginning of therapy, a stable therapeutic effect occurs after two weeks of treatment and can increase over several months of treatment. Long-term treatment. The duration of treatment is determined individually.
Overdose
Symptoms: nausea, vomiting, convulsions. Treatment: gastric lavage, taking activated charcoal, symptomatic therapy.
Description
Histamine Repair
Description
Tablets are almost white or white with a creamy tint of color, flat-cylindrical with a chamfer and risk.
Functional features
It is absorbed quickly, and the binding to plasma proteins is low. The time to reach the maximum concentration in blood plasma is 3 hours. It is almost completely excreted by the kidneys as a metabolite (2-pyridylacetic acid) within 24 hours. The elimination half-life is 3 — 4 hours.
Complete set
Tablets 24 mg. 10 or 30 tablets in a contour cell pack. 30 tablets each in a polymer jar. 3 contour cell packs of 10 tablets each,1,2 or 3 contour cell packs of 30 tablets each, or a polymer jar together with instructions for use in a cardboard pack.
Special instructions
Effects on the ability to drive a car and other mechanisms of action Betahistine does not have a sedative effect and does not affect the ability to drive a car or engage in activities that require rapid psychomotor reactions.
Form of production
Tablets
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of reach of children.
Shelf
life is 3 years. Do not use after the expiration date indicated on the package.
Active ingredient
Betahistine
Conditions of release from pharmacies
By prescription
Dosage form
Tablets
Description
For adults as directed by your doctor
Indications
Meniere’s disease, Cerebrovascular Accident
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