Indications
Degenerative-dystrophic diseases of the joints and spine:
- stage I–III osteoarthritis;
- osteochondrosis.
$139.00
Active ingredient: | |
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Dosage form: | |
Indications for use: | Arthritis, Arthrosis, Lumbago, Osteochondrosis, Radiculitis, Rheumatoid arthritis, Sciatica |
Degenerative-dystrophic diseases of the joints and spine:
Inside, regardless of food intake, with a small amount of water.
Adults and children over 15 years of age-in the first 3 weeks appoint 1 capsule 3 times a day; in subsequent days-1 capsule 2 times a day.
The recommended duration of treatment is 3 to 6 months.
If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.
With caution, the drug should be prescribed for diabetes mellitus, a tendency to bleeding, and bronchial asthma.
1 capsule contains:
Active ingredients:
glucosamine hydrochloride-500 mg,
chondroitin sodium sulfate-400 mg;
Excipients:
sodium sulfate,
stearic acid,
magnesium stearate,
manganese sulfate.
1 capsule contains:
Active ingredients:
glucosamine hydrochloride-500 mg,
chondroitin sodium sulfate-400 mg;
Auxiliary substances:
sodium sulfate,
stearic acid,
magnesium stearate,
and manganese sulfate.
Theraflex-stimulates the regeneration of cartilage tissue. Glucosamine and chondroitin sulfate sodium are involved in the synthesis of connective tissue, helping to prevent the destruction of cartilage and stimulating tissue regeneration.
The introduction of exogenous glucosamine enhances the production of the cartilage matrix and provides non-specific protection against cartilage damage. Another possible effect of glucosamine is to protect damaged cartilage from the metabolic destruction caused by NSAIDs and corticosteroids, as well as its own moderate anti-inflammatory effect.
Chondroitin sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. It stimulates the formation of hyaluronic acid, the synthesis of proteoglycans and type II collagen, and also protects hyaluronic acid from enzymatic degradation (by suppressing the activity of hyaluronidase); maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms, and suppresses the activity of those enzymes (elastase, hyaluronidase) that break down cartilage.
In the treatment of osteoarthritis, it eases the symptoms of the disease and reduces the need for NSAIDs.
Pharmacokinetics
Glucosamine
Absorption. Oral bioavailability of glucosamine is 25% (first-pass effect through the liver).
Metabolism. After absorption of an oral dose, radioactively labeled glucosamine is initially detected in plasma and later penetrates into tissues. The highest concentrations are found in the liver, kidneys, and articular cartilage. About 30% of the dose taken persists for a long time in the tissues of bones and muscles.
Elimination. It is excreted mainly by the kidneys in unchanged form; partially-through the intestines. T1 / 2 of the drug is 68 h
. Chondroitin sulfate
Absorption. When taking chondroitin sulfate orally once at a dose of 0.8 g (or 2 times a day for 0.4 g), the plasma concentration increases over 24 hours. Absolute bioavailability is 12%.
Metabolism. It is metabolized by desulfurization.
Elimination. It is excreted by the kidneys. T1 / 2 — 310 min.
Degenerative-dystrophic diseases of the joints and spine:
Contraindicated during pregnancy and lactation.
With caution, the drug should be prescribed for diabetes mellitus, a tendency to bleeding, and bronchial asthma.
Theraflex is well tolerated by patients.
Possible gastrointestinal disorders (epigastric pain, flatulence, diarrhea, constipation), dizziness, headache, leg pain and peripheral edema, drowsiness, insomnia, tachycardia, allergic reactions.
Improves the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins and chloramphenicol.
The drug is compatible with NSAIDs and corticosteroids.
Chondroitin sulfate may enhance the effect of anticoagulants.
Inside, regardless of food intake, with a small amount of water.
Adults and children over 15 years of age-in the first 3 weeks appoint 1 capsule 3 times a day; in subsequent days-1 capsule 2 times a day.
The recommended duration of treatment is 3 to 6 months.
If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.
Stronger composition-healthier joint(1). Theraflex Theraflex drug No. 1 for the treatment of osteoarthritis and osteochondrosis(2). Theraflex is a modern chondroprotector that is manufactured in the United States in accordance with Bayer’s high quality standards. It is proved(3) that Theraflex contributes to: – Renewal of joint cartilage tissue-Improvement of joint mobility – Reduction of pain prevents further development of the disease(4). Theraflex has a complex effect: it helps restore the cartilage tissue of the joint, as well as reducing the need for painkillers, increasing the safety of treatment. Unlike some other drugs of the group, it contains an increased daily dosage (5) of some of the most studied active substances: glucosamine and chondroitin(6). Theraflex is available in an ideal capsule form(7), therefore-it includes only the necessary active ingredients without unnecessary additional impurities-it is easily absorbed by the body Theraflex must be taken in courses, the effect of treatment can occur gradually and is designed to last for a long time(8). The course of treatment is from 3 to 6 months: the first three weeks are prescribed a capsule 3 times a day; in the following days, a capsule 2 times a day. Keep your joints healthy by taking courses 2 times a year, and your joints will thank you. (9)1. Fransen M. et al. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis. 2015 May;74(5): 851-8.2. According to the data of Ai Em Es Health LLC obtained from the database Retail Audit of GLS and dietary supplements in the Russian Federation, Theraflex is the leader in sales of drugs from the groups 02G2C Joint preparations, systemic,02 E 2 C Drugs for muscle pain, systemic and 02 E 1 O Drugs for muscle pain for external use (OTS classification) for the periods September 2016 August 2017.3. Chichasova N. V. Treatment of pain in patients with osteoarthritis of various localization // Medical advice. – 2014. – â„–17. – 96-102.4. After 3 years of Theraflex therapy, the number of patients with radiological progression of gonarthrosis differed by 25% from the control group (p < 0.05). Svetlova M. S. Pathogenetic treatment of knee osteoarthritis / / Modern rheumatology. – 2012. – No. 3. – p. 44- 495. Recommended daily doses when taking Theraflex capsules exceed those of some glucosamine and chondroitin preparations, according to the GRLS database as of 26.07.2018 6. Kadurina T. N., Abbakumova L. N. Principles of rehabilitation of patients with connective tissue dysplasia. 2010. No. 4. p. 1719.7. For combination medications. Cole G. Evaluating Development and Production Costs: Tablets Versus Capsules. Pharmaceutical Technology Europe; Vol. 5, Pgs. 17Â 26 (1998).8. According to a comparative study involving 100 patients with OA, the effect of pain relief persisted for 3 months after discontinuation of treatment. Alekseeva L. I., Kashevarova N. G., Sharapova E. P., Zaitseva E. M., Severinova M. V. Comparison of permanent and intermittent treatment of patients with knee osteoarthritis with the combined drug Theraflex. – 200 – No. 3. -pp. 68-72.9. Federal clinical guidelines for the diagnosis and treatment of osteoarthritis, Association of Rheumatologists of Russia,2016,19 p.
If there are undesirable effects from the gastrointestinal tract, the dose of the drug should be reduced by 2 times, and if there is no improvement, the drug should be discontinued.
Capsules
Store in a dry place, protected from light, at temperatures below 25 °C
3 years
Glucosamine, Chondroitin Sulfate
Capsules
Children over 12 years old, For adults
Sciatica, Lumbago, Osteochondrosis, Rheumatoid Arthritis, Osteoarthritis, Sciatica, Arthritis, Arthrosis
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